ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (5): 431-435.

• 小儿中药应用研究 • 上一篇    下一篇

小儿咳嗽用药规律研究

目的:总结分析中医专家治疗小儿咳嗽的用药及组方规律。
方法:收集汪永红主任2019年4～10月治疗咳嗽的病历，录入“中医传承辅助平台（V2-5）”系统，采用系统中的关联规则、复杂系统熵聚类、无监督的熵层次聚类等数据挖掘方法，统计汪主任治疗咳嗽的中药使用频次，分析常用药物之间关联规则，挖掘核心药物组合及潜在核心处方。
结果:筛选出301首小儿咳嗽处方，经统计使用频次最高的四味药物为黄芩、杏仁、陈皮、制半夏；经药物关联规则分析得到治疗小儿咳嗽的核心处方：黄芩、杏仁、陈皮、制半夏、蝉蜕、款冬花、茯苓、桑白皮、炒白术；经熵聚类分析法得出治疗小儿咳嗽核心药物组合8组及潜在新处方4个。
结论:小儿咳嗽的发生多由“肺脾同病、外邪袭肺”所致，治疗时遵从“肺脾同治”的原则，善用定喘汤、止嗽散、二陈汤三方相合加减治疗。   

  1. 200082 上海，上海市中西医结合医院儿科（杜琳麟）；201102 上海，复旦大学附属儿科医院中医科（汪永红，和婧伟）
  • 出版日期:2021-10-25 发布日期:2021-12-06
  • 通讯作者: 汪永红，E-mail:wyhekyy@126.com
  • 作者简介:杜琳麟（1986-），女，医学硕士，主治医师，研究方向：中西医结合治疗儿科疾病
  • 基金资助:
    上海市杏林新星计划（ZY(2018-2020)-RCPY-3022）；上海市虹口区卫健委中医药科研课题（HKQ-ZYY-2020-27）；国家中医药管理局时毓民全国名老中医传承工作室项目［国中医药人教发（2016）42号］

Study on the medication rules for cough in children

Objective:To summarize and analyze the rules of medication and prescriptions of Traditional Chinese Medicine(TCM) experts in treating children with cough.#br# Methods:The child cases of cough treated by chief physician Wang Yonghong between April 2019 and October 2019 were collected and entered into TCM Inheritance Support System(V2.5).The association rules, entropy clustering of complex systems，unsupervised entropy hierarchical clustering and other data mining methods were used to count the frequency of the herbs in chief physician Wang's prescriptions for cough. Analyze the association rules between commonly used herbs，and excavate prescription herbs combinations and potential core prescriptions. #br# Results:Among the 301 collected prescriptions for children's cough，the four most frequently used herbs were Huangqin(Radix Scutellariae Baicalensis)，Xingren(Semen Armeniacae Amarum)，Chenpi(Citrusreticulata Blanco)，Zhibanxia(prepared Rhizoma Pinelliae);the core prescription for children's cough was extracted by the association rule analysis ，which contained these following herbs:Huangqin(Radix Scutellariae Baicalensis)，Xingren(Semen Armeniacae Amarum)，Chenpi(Citrusreticulata Blanco)，Zhibanxia(prepared Rhizoma Pinelliae)，Chantui(Periostracum Cicadae)，Kuandonghua(Flos Farfarae)，Fuling(Poria)，Sangbaipi(Morus albaL)，Chaobaizhu(roasted Rhizoma Atractylodis Macrocephalae);8 groups of core herb combination and 4 potential prescriptions for cough were obtained by using the entropy clustering analysis method.#br# Conclusion:The cough in children is most likely caused by "diseased lung and spleen，exogenous evil attacking lung"， so we should follow the principle of "simultaneous treatment of lung and spleen" during treatment. The combination of Dingchuan decoction，Zhisou powder and Erchen decoction should be used with modification to treat cough in children.   

  1. Department of Pediatrics，Shanghai Traditional Chinese Medicine Integrated Hospital，Shanghai 200082，China
  • Online:2021-10-25 Published:2021-12-06

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摘要： 目的:总结分析中医专家治疗小儿咳嗽的用药及组方规律。
方法:收集汪永红主任2019年4～10月治疗咳嗽的病历，录入“中医传承辅助平台（V2-5）”系统，采用系统中的关联规则、复杂系统熵聚类、无监督的熵层次聚类等数据挖掘方法，统计汪主任治疗咳嗽的中药使用频次，分析常用药物之间关联规则，挖掘核心药物组合及潜在核心处方。
结果:筛选出301首小儿咳嗽处方，经统计使用频次最高的四味药物为黄芩、杏仁、陈皮、制半夏；经药物关联规则分析得到治疗小儿咳嗽的核心处方：黄芩、杏仁、陈皮、制半夏、蝉蜕、款冬花、茯苓、桑白皮、炒白术；经熵聚类分析法得出治疗小儿咳嗽核心药物组合8组及潜在新处方4个。
结论:小儿咳嗽的发生多由“肺脾同病、外邪袭肺”所致，治疗时遵从“肺脾同治”的原则，善用定喘汤、止嗽散、二陈汤三方相合加减治疗。

关键词: 咳嗽, 中医药治疗, 用药经验, 中医传承辅助平台, 儿童

Abstract: Objective:To summarize and analyze the rules of medication and prescriptions of Traditional Chinese Medicine(TCM) experts in treating children with cough.
Methods:The child cases of cough treated by chief physician Wang Yonghong between April 2019 and October 2019 were collected and entered into TCM Inheritance Support System(V2.5).The association rules, entropy clustering of complex systems，unsupervised entropy hierarchical clustering and other data mining methods were used to count the frequency of the herbs in chief physician Wang's prescriptions for cough. Analyze the association rules between commonly used herbs，and excavate prescription herbs combinations and potential core prescriptions. 
Results:Among the 301 collected prescriptions for children's cough，the four most frequently used herbs were Huangqin(Radix Scutellariae Baicalensis)，Xingren(Semen Armeniacae Amarum)，Chenpi(Citrusreticulata Blanco)，Zhibanxia(prepared Rhizoma Pinelliae);the core prescription for children's cough was extracted by the association rule analysis ，which contained these following herbs:Huangqin(Radix Scutellariae Baicalensis)，Xingren(Semen Armeniacae Amarum)，Chenpi(Citrusreticulata Blanco)，Zhibanxia(prepared Rhizoma Pinelliae)，Chantui(Periostracum Cicadae)，Kuandonghua(Flos Farfarae)，Fuling(Poria)，Sangbaipi(Morus albaL)，Chaobaizhu(roasted Rhizoma Atractylodis Macrocephalae);8 groups of core herb combination and 4 potential prescriptions for cough were obtained by using the entropy clustering analysis method.
Conclusion:The cough in children is most likely caused by "diseased lung and spleen，exogenous evil attacking lung"， so we should follow the principle of "simultaneous treatment of lung and spleen" during treatment. The combination of Dingchuan decoction，Zhisou powder and Erchen decoction should be used with modification to treat cough in children.

Key words: Cough, TCM treatment, Medication experience, Traditional Chinese Medicine(TCM) inheritance support system, Children