ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (6): 628-630.doi: 10.3969/j.issn.1674-3865.2016.06.026

• 临床研究 • 上一篇    下一篇

西替利嗪联合用药治疗小儿咳嗽变异性哮喘疗效观察

陈丽丽   

  1. 110042 沈阳，沈阳市二四五医院儿科
  • 出版日期:2016-12-25 发布日期:2018-11-19
  • 作者简介:陈丽丽(1982-)，女，主治医师。研究方向：小儿呼吸系统疾病的诊治，E-mail：75485078@qq.com

Observation on the effect of combined cetirizine therapy for children with cough variant asthma

CHEN Lili   

  1. No.245 Hospital of Shenyang, Shenyang 110042,China
  • Online:2016-12-25 Published:2018-11-19

PDF (PC)

104

摘要： 目的：观察西替利嗪联合用药治疗小儿咳嗽变异性哮喘的疗效。
方法：2014年8月至2016年3月沈阳市二四五医院儿科收治住院的小儿咳嗽变异性哮喘患儿120例，随机分为观察组和对照组各60例。对照组给予西替利嗪滴剂，观察组在对照组治疗基础上，每日服用射干麻黄汤加减治疗，均连续治疗2周。比较两组疗效及症状体征消失时间、不良反应、随访6个月后复发情况。
结果：观察组治疗总有效率为91.7%(55/60)，高于对照组71.7%(43/60)，差异有统计学意义(P<0.05)。观察组患儿哮喘消失时间、哮喘持续时间、肺哮鸣音消失时间均明显少于对照组，差异有统计学意义(P<0.05)。观察组复发2例(3.33%)，低于对照组8例(13.33%)，差异有统计学意义(P<0.05)。观察组不良反应发生率为3.33%(2/60)，明显低于对照组13.33%(8/60)，差异有统计学意义(P<0.05)。
结论：西替利嗪联合射干麻黄汤加减治疗小儿咳嗽变异性哮喘的临床效果显著，不良反应少，总有效率高，复发率低，值得临床推广。

关键词: 变异性哮喘, 咳嗽, 西替利嗪, 射干麻黄汤, 儿童

Abstract: Objective:To observe the effect of combined cetirizine therapy for children with cough variant asthma.
Methods:A total of 120 children with cough variant asthma were admitted to No.245 Hospital of Shenyang from Aug. 2014 to Mar. 2016, and they were randomly divided into two groups: 60 in observation group and 60 in control group. The control group was given cetirizine drops and the observation group received additional treatment, taking Shegan Mahuang decoction orally every day, continuously for two weeks. Compare the curative effect, disappearance time of signs and symptoms and adverse reactions between the two groups. The relapse was followed up six months later.
Results:The total effective rate of observation group was 91.7%(55/60),higher than that of the control group(71.7%，43/60),and the difference was statistical(P<0.05).The time for asthma to disappear, the lasting time of asthma and the time for pulmonary wheezes to disappear in observation group were all significantly less than those of control group, and there was statistical difference(P<0.05).There were two cases of relapse(3.33%) in observation group, lower than that of control group (8 cases,13.33%) with statistical difference（P<0.05）. The rate of adverse reactions in observation group was 3.33%(2/60), which was significantly lower than the control group(13.33%，8/60), and there was statistical difference(P<0.05).
Conclusion：The combined therapy of cetirizine with Shegan Mahuang decoction has great clinical effect on children with cough variant asthma, with fewer adverse reactions, high total effective rate and low recurrence rate, which is worthy of clinical popularization.

Key words: Variant asthma, Cough, Cetirizine, Shegan Mahuang decoction, Children