Abstract: Objective:To investigate the clinical effect of pulmonary recruitment maneuvers combined with pressure adjustment volume control in premature infants with severe respiratory distress syndrome.Methods:Sixty premature infants with moderate to severe(grade ⅢⅣ) respiratory distress syndrome who were admitted to the People's Hospital of Ruyang County from October 2015 to December 2016 were selected. They were divided into observation group(30 cases) and control group(38 cases) according to the treatment regimen. The control group received mechanical ventilation, and the mode was pressure adjustment volume control mode. The observation group received pulmonary re extension in addition to the treatment for the control group. The clinical efficacy of the two groups was observed. Ventilatory parameters were compared before and after pulmonary recruitment maneuvers. The time of taking up the machine, the time of oxygen therapy, the use of second surfactant and the complications of the two groups were recorded.Results:The arterial oxygen pressure (PaO2), carbon dioxide partial pressure (PaCO2) and oxygenation index (PaO2/FiO2) of the observation group were (87.7±12.4) mm Hg, (48.6±9.2) mm Hg and (266.8±63.5) mm Hg, respectively, which were significantly better than those in the control group［(73.6±9.5) mm Hg, (57.4±8.6) mm Hg, (218.5±57.3) mm Hg］(P<0.05). In the observation group, the time of taking up the machine, oxygen therapy time, the use of second pulmonary surfactant and the incidence of complications were all lower than those in the control group(P<0.05).Conclusion:For children with moderate to severe respiratory distress syndrome, pulmonary recruitment maneuvers and pressure modulated volume control can help relieve or eliminate clinical symptoms, improve the clinical efficacy and reduce the incidence of complications.

Key words: Respiratory distress syndrome, Mechanical ventilation, Pulmonary recruitment maneuvers, Premature infant