ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (6): 643-646.doi: 10.3969/j.issn.1674-3865.2016.06.031

• 调查研究 • 上一篇    下一篇

脑性瘫痪患儿血清25羟基维生素D水平分析

廖新，齐腾澈，文江舸，李娜，齐尧   

  1. 110032 沈阳，沈阳市儿童医院儿童保健科(廖新，文江舸，李娜)，神经康复三科(齐腾澈)，儿内科(齐尧)
  • 出版日期:2016-12-25 发布日期:2018-11-19
  • 通讯作者: 廖新，E-mail：liaoxin77@sina.com
  • 作者简介:廖新(1977-)，女，医学硕士，副主任医师。研究方向：儿童生长发育及营养相关性疾病

Analysis of serum 25 hydroxy vitamin D level of children with cerebral palsy

LIAO Xin，QI Tengche，WEN Jiangge，LI Na，QI Yao   

  1. Shenyang Children's Hospital，Shenyang 113200，China
  • Online:2016-12-25 Published:2018-11-19

PDF (PC)

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摘要： 目的：分析脑性瘫痪(简称脑瘫)患儿维生素D的营养状况。
方法：2015年4月至2015年6月沈阳市儿童医院康复科收治住院的脑瘫患儿113例为观察组，选择同期在本院健康体检的儿童150例为对照组。采用高效液相色谱-串联质谱法对脑瘫患儿和体检儿童血清中25羟基维生素D［25(OH)D］水平进行检测，比较两组儿童25(OH)D水平的差异。
结果：观察组总体血清25(OH)D水平为(20.7±6.0)μg/L，明显低于对照组(25.3±7.5)μg/L，差异有统计学意义(P<0.01)；各年龄段观察组25(OH)D水平均低于同年龄对照组，差异有统计学意义(P<0.05)。观察组1～3岁和>3～6岁25(OH)D不足和缺乏发生率高于对照组，差异有统计学意义(P<0.05)，>6～12岁两组25(OH)D不足和缺乏发生率比较差异无统计学意义(P>0.05)。
结论：脑瘫患儿血清25(OH)D水平明显低于健康儿童，在对脑瘫患儿进行常规康复训练的同时应关注维生素D水平，从而有利于患儿获得更好的康复效果。

关键词: 脑性瘫痪, 维生素D, 儿童

Abstract: Objective:To analyze vitamin D(Vit D) level of children with cerebral palsy in Shenyang.
Methods:From April 2015 to June 2015,113 children with cerebral palsy hospitalized in the Rehabilitation Department of Shenyang Children's Hospital aged 1~12 were selected as the observation group,150 confirmed by healthy children roution physical examination aged 1~12 were selected as the control group. High performance liquid chromatography was used to detect the level of serum Vit D, and 25(OH)D levels were compared between the two groups.
Results:The average level of 25(OH)D (20.7±6.0 μg/L) of observation group was lower than that of the control group（25.3±7.5 μg/L），the difference being significant(P<0.01）. The level of 25(OH)D of observation group was lower than that of control group among all the age groups（P<0.05）. The incidence of 25(OH)D insufficiency and 25(OH)D deficiency in 1~3 age group and >3~6 age group of observation group was higher than that in control group, and the difference was significant（P<0.05）;there was no significant difference on the incidence of 25(OH)D insufficiency and 25(OH)D deficiency in >6~12 age group（P＞0.05）.
Conclusion：The serum level of 25(OH)D in children with cerebral palsy is significantly lower than that in healthy children. In order to get better rehabilitation effect, in addition to routine rehabilitation training for children with cerebral palsy, we should also pay attention to the level of 25(OH)D.

Key words: Cerebral palsy, Vitamin D, Children