ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (4): 326-329.doi: 10.3969/j.issn.1674-3865.2019.04.014

• 临床研究 • 上一篇    下一篇

542例儿童过敏性紫癜回顾性分析

司秀影，王海   

  1. 150040 哈尔滨，黑龙江中医药大学2017级中医儿科学专业研究生(司秀影)；黑龙江中医药大学附属第一医院儿科(王海)
  • 收稿日期:2019-04-02 出版日期:2019-08-25 上线日期:2019-08-25
  • 通讯作者: 王海，E-mail：782955547@qq.com
  • 作者简介:司秀影(1992-)，女，黑龙江中医药大学2017级硕士研究生在读。研究方向：中医药治疗儿童泌尿系统疾病

Retrospective analysis of 542 children with Henoch-Schonlein purpura

SI Xiuying，WANG Hai   

  1.  Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China
  • Received:2019-04-02 Published:2019-08-25 Online:2019-08-25
  • Contact: WANG Hai，E-mail：782955547@qq.com

PDF (PC)

93

摘要： 目的 了解儿童过敏性紫癜(HSP)的流行病学特点，观察HSP患儿的预后状况，对HSP患儿远期尿液常规异常的相关危险因素进行分析。方法收集2010年10月至2017年9月在黑龙江中医药大学附属第一医院确诊为HSP的住院患儿的临床资料、回访情况等进行回顾性分析。结果 HSP患儿发病的首要诱因是呼吸道感染；92.62%(502/542)HSP患儿以皮肤紫癜为首发症状，住院期间有肾脏损害的患儿占15.13%(82/542)；HSP复发患儿21.34%(89/417)；远期尿常规异常与住院诊断肾型(OR=4.589,95CI2.357~8.934)、发病年龄≥6岁(OR=2.113，95%CI1.094~4.079)及紫癜反复发作(OR=2.403，95%CI1.249~4.622)密切相关。结论 HSP患儿容易反复出现皮肤紫癜，住院时有肾脏损害的患儿更易复发(P=0.006<0.05)；远期尿常规异常与住院诊断肾型、发病年龄≥6岁及紫癜反复发作相关，与入院时诊断为腹型紫癜无明显关系(P=0.241>0.05)。

关键词: 紫癜, 过敏性, 肾损害, 远期预后, 儿童

Abstract: ObjectiveTo understand the epidemiological characteristics of Henoch-Schonlein purpura(HSP) in children, observe the prognosis of children with HSP, and analyze the risk factors of long-term urinary abnormalities in children with HSP.MethodsCollect and retrospectively analyze the clinical data and feedback of hospitalized children diagnosed with HSP in the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from October 2010 to September 2017.Results Respiratory tract infection is the leading cause of the onset of HSP in children. Skin purpura is the first symptom of HSP in 502/542(92.62%) children, and 15.13%(82/542) hospitalized children had kidney damage; 21.34%(89/417) children had HSP recurrence. The long-term urinary routine was closed related to kidney type of in-hospital diagnosis(OR =4.589, 95%CI 2.357-8.934), children's age at onset being greater than or equal to 6 years old(OR =2.113, 95%CI 1.094-4.079) and recurrent purpura(OR=2.403, 95%CI 1.249-4.622).ConclusionThe children with HSP are prone to recurrent skin purpura, and hospitalized children with kidney damage are prone to recurrence(P=0.006<0.05); long-term abnormal routine urine is related to the kidney type of in-hospital diagnosis, onset age ≥6 and recurrent purpura, but is not related to the in-hospital diagnosis of abdominal purpura(P >0.05).

Key words: Purpura, Allergy, Renal damage, Long-term prognosis, Children