ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (2): 138-.

• 临床研究 • 上一篇    下一篇

血清降钙素原、C反应蛋白、白细胞介素-6 水平在小儿骨关节感染中的水平变化及临床意义

杨佳丽，翟慢慢，李志浩   

  1. 450003 郑州，郑州大学附属儿童医院，河南省儿童医院，郑州儿童医院输血科
  • 出版日期:2021-04-25 发布日期:2021-05-18
  • 通讯作者: 翟慢慢，E-mail：yangjiali9104@163.com
  • 作者简介:杨佳丽（1991-），女，初级检验师。研究方向：临床检验与输血
  • 基金资助:
    2018年河南省科技攻关计划项目（2018020658）

Changes of serum PCT, CRP and IL-6 levels in pediatric bone and joint infections and their clinical significance

YANG Jiali, ZHAI Manman, LI Zhihao   

  1. Department of Blood Transfusion, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou 450003，China
  • Online:2021-04-25 Published:2021-05-18

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摘要： 目的:探讨血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6（IL-6）在小儿骨关节感染中的水平变化及临床意义。
方法:选择2015年12月至2017年12月郑州大学附属儿童医院收治住院的骨关节感染患儿90例为观察组，同期选取健康体检儿童90例为对照组。所有小儿均检测血清PCT、CRP、IL-6水平。统计两组血清PCT、CRP、IL-6水平，不同类型骨关节感染患儿血清PCT、CRP、IL-6水平，急性感染期及恢复期患儿血清PCT、CRP、IL-6水平，不同病情程度患儿血清PCT、CRP、IL-6水平。
结果:观察组血清PCT、CRP、IL-6水平均高于对照组，差异有统计学意义（P<0.05）。化脓性关节炎患儿血清PCT、CRP、IL-6水平均高于急性骨髓炎及慢性骨髓炎患儿，差异有统计学意义（P<0.05）。骨关节感染患儿急性感染期血清PCT、CRP、IL-6水平均高于恢复期，差异有统计学意义（P<0.05）。重度感染患儿血清PCT、CRP、IL-6水平均高于轻度感染患儿，差异有统计学意义（P<0.05）。
结论:血清中PCT、CRP、IL-6水平对于临床评估骨关节感染患儿的病情有重要意义。

关键词: 骨关节感染, 降钙素原, C反应蛋白, 白细胞介素-6, 儿童

Abstract: Objective:To explore the changes in the levels of serum procalcitonin(PCT), C-reactive protein(CRP) and interleukin-6(IL-6)，and their clinical significance in pediatric bone and joint infections.
Methods:Ninety child patients with bone and joint infections who were treated in Children's Hospital Affiliated to Zhengzhou University from December 2015 to December 2017 were included as case group. Another 90 healthy children with physical examination during the same period were selected as control group. The levels of serum PCT, CRP and IL-6 were measured. The levels of serum PCT, CRP and IL-6 in case group and control group were statistically analyzed. The levels of serum PCT, CRP and IL-6 among child patients with different types of bone and joint infections were statistically analyzed. The levels of serum PCT, CRP and IL-6 among children in acute infection and recovery phase were statistically analyzed. The levels of serum PCT, CRP and IL-6 among child patients with different disease severity were statistically analyzed.
Results:The levels of serum PCT, CRP and IL-6 in case group were higher than those in control group (P<0.05).The serum levels of PCT, CRP and IL-6 in child patients with suppurative arthritis were higher than those in child patients with acute osteomyelitis and chronic osteomyelitis (P<0.05). The serum levels of PCT, CRP and IL-6 of child patients with bone and joint infections in acute infection phase were higher than those in recovery phase (P<0.05). The serum levels of PCT, CRP and IL-6 in child patients with severe infections were higher than those in child patients with mild infections (P<0.05).
Conclusion:The serum levels of PCT, CRP and IL-6 are of important significance in clinically evaluating conditions of children with bone and joint infections.

Key words: Bone and joint infections, Procalcitonin, C-reactive protein, Interleukin-6, Children