ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (4): 281-.

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苇茎涤痰汤治疗儿童迁延性细菌性支气管炎疗效观察

目的:观察自拟苇茎涤痰汤治疗儿童迁延性细菌性支气管炎的疗效。
方法:以2017年3月至2018年3月黑龙江中医药大学附属第一医院儿科收治迁延性细菌性支气管炎患儿82例为研究对象，随机分为观察组42例，对照组40例。观察组给予苇茎涤痰汤治疗，对照组给予盐酸氨溴索口服溶液联合阿莫西林克拉维酸钾治疗，疗程3周。有效性指标为咳嗽症状积分、中医证候积分、肺CT异常评分。
结果:治疗3周后，观察组的总有效率为88.1%(37/42)，明显高于对照组70.0％(28/40)，差异有统计学意义（P<0.05）；治疗后，两组患儿的咳嗽症状评分，痰浊蕴肺、肺失宣降证中医主、次要症状评分均较治疗前明显降低（P<0.05），且观察组的降低作用均明显优于对照组，差异均有统计学意义（P<0.05）；治疗后，17例有阻塞性通气障碍的患儿中，16例经治疗3周后转为正常，1例治疗2周后重度转为中度；治疗后，观察组17例、对照组14例患儿CT病变严重程度评分均较治疗前明显减少，且观察组CT影响明显减轻，差异均有统计学意义（P<0.05）。
结论:苇茎涤痰汤治疗儿童迁延性细菌性支气管炎，能够显著改善咳嗽症状及中医证候，明显改善肺通气功能和高分辨率断层扫描表现。   

  1. 150040 哈尔滨，黑龙江中医药大学2018级中医儿科学专业研究生(王圣楠)；黑龙江中医药大学附属第一医院儿科二科(王国杰，王海)
  • 出版日期:2021-08-25 发布日期:2021-12-07
  • 通讯作者: 王海，E-mail：782955547@qq.com
  • 作者简介:王圣楠（1992-），女，黑龙江中医药大学2018级硕士研究生在读。研究方向：中医药治疗呼吸系统疾病
  • 基金资助:
    国家中医药管理局国家中医临床研究基地业务建设科研专项课题（JDZX20150360）

Observation on the effect of Weijing Ditan decoction in the treatment of children with protracted bacterial bronchitis

Objective:To observe the therapeutic effect of self-made Weijing Ditan decoction on children with protracted bacterial bronchitis.#br# Methods:From March 2017 to March 2018，82 children with protracted bacterial bronchitis were treated in the First Affiliated Hospital of Heilongjiang TCM University, and they were randomly divided into experimental group(42 cases) and control group(40 cases). The experimental group was treated withWeijing Ditan decoction，while the control group was treated with ambroxol hydrochloride oral solution combined with amoxicillin and clavulanate potassium, for 3 weeks. The effective indexes were cough symptom score， TCM syndrome score and lung CT abnormality score.#br# Results:After 3 weeks of treatment，the total effective rate of the experimental group was 88.1%(37/42)， which was significantly higher than that of the control group (70.0％，28/40) (P<0.05).After treatment， the cough symptom score， the primary andsecondary symptom scores of Tanzhuoyunfei and Feishixuanjiang syndrome of the two groups were significantly lower than thosebefore treatment (P<0.05)， and the reduction effect of the experimental group was significantly better than that of the control group，the differences being statistically significant(P<0.05). After treatment， among the 17 cases of obstructive ventilation disorder，16 cases turned to normal after 3 weeks of treatment，and 1 case turned to moderate after 2 weeks of treatment.After treatment， the CT severity scores of 17 cases in the experimental group and 14 cases in the control group were significantly reduced compared with those before treatment，and the influenceof CT in experimental group was more significantly reduced(P<0.05).#br# Conclusion:Weijing Ditan decoction in the treatment of children with protracted bacterial bronchitis can significantly improvecough symptoms and TCM syndromes， and significantly improve pulmonary ventilation function and HRCT performance.   

  1. Heilongjiang University of Traditional Chinese Medicine，Harbin 150040，China
  • Online:2021-08-25 Published:2021-12-07

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摘要： 目的:观察自拟苇茎涤痰汤治疗儿童迁延性细菌性支气管炎的疗效。
方法:以2017年3月至2018年3月黑龙江中医药大学附属第一医院儿科收治迁延性细菌性支气管炎患儿82例为研究对象，随机分为观察组42例，对照组40例。观察组给予苇茎涤痰汤治疗，对照组给予盐酸氨溴索口服溶液联合阿莫西林克拉维酸钾治疗，疗程3周。有效性指标为咳嗽症状积分、中医证候积分、肺CT异常评分。
结果:治疗3周后，观察组的总有效率为88.1%(37/42)，明显高于对照组70.0％(28/40)，差异有统计学意义（P<0.05）；治疗后，两组患儿的咳嗽症状评分，痰浊蕴肺、肺失宣降证中医主、次要症状评分均较治疗前明显降低（P<0.05），且观察组的降低作用均明显优于对照组，差异均有统计学意义（P<0.05）；治疗后，17例有阻塞性通气障碍的患儿中，16例经治疗3周后转为正常，1例治疗2周后重度转为中度；治疗后，观察组17例、对照组14例患儿CT病变严重程度评分均较治疗前明显减少，且观察组CT影响明显减轻，差异均有统计学意义（P<0.05）。
结论:苇茎涤痰汤治疗儿童迁延性细菌性支气管炎，能够显著改善咳嗽症状及中医证候，明显改善肺通气功能和高分辨率断层扫描表现。

关键词: 迁延性细菌性支气管炎, 苇茎涤痰汤, 痰浊蕴肺、肺失宣降证, 儿童

Abstract: Objective:To observe the therapeutic effect of self-made Weijing Ditan decoction on children with protracted bacterial bronchitis.
Methods:From March 2017 to March 2018，82 children with protracted bacterial bronchitis were treated in the First Affiliated Hospital of Heilongjiang TCM University, and they were randomly divided into experimental group(42 cases) and control group(40 cases). The experimental group was treated withWeijing Ditan decoction，while the control group was treated with ambroxol hydrochloride oral solution combined with amoxicillin and clavulanate potassium, for 3 weeks. The effective indexes were cough symptom score， TCM syndrome score and lung CT abnormality score.
Results:After 3 weeks of treatment，the total effective rate of the experimental group was 88.1%(37/42)， which was significantly higher than that of the control group (70.0％，28/40) (P<0.05).After treatment， the cough symptom score， the primary andsecondary symptom scores of Tanzhuoyunfei and Feishixuanjiang syndrome of the two groups were significantly lower than thosebefore treatment (P<0.05)， and the reduction effect of the experimental group was significantly better than that of the control group，the differences being statistically significant(P<0.05). After treatment， among the 17 cases of obstructive ventilation disorder，16 cases turned to normal after 3 weeks of treatment，and 1 case turned to moderate after 2 weeks of treatment.After treatment， the CT severity scores of 17 cases in the experimental group and 14 cases in the control group were significantly reduced compared with those before treatment，and the influenceof CT in experimental group was more significantly reduced(P<0.05).
Conclusion:Weijing Ditan decoction in the treatment of children with protracted bacterial bronchitis can significantly improvecough symptoms and TCM syndromes， and significantly improve pulmonary ventilation function and HRCT performance.

Key words: Protracted bacterial bronchitis, Weijing Ditan decoction, Tanzhuoyunfei and Feishixuanjiang syndrome, Children