关键词: 反复呼吸道感染, 匹多莫德, 维生素AD, 免疫功能, 儿童

Abstract: Objective:To explore the effect of pidotimod combined with vitamin AD in the treatment of recurrent respiratory tract infection in children.Methods:Totally 195 cases of recurrent respiratory tract infection in children treated in our hospital from February 2018 to August 2019 were selected, and they were divided into 3 groups: pidotimod group(A), vitamin AD group(B), and combination group(C). Group A(65 children) were treated with pidotimod, group B(65 children) were treated with vitamin AD, and group C(65 children) were treated with pidotimod combined with vitamin AD. The total effective rate, immune function index, the relief time of clinical symptoms and the average times of recurrence during the one-year follow-up were compared among the three groups.Results:The total effective rate in group C(98.46%,64/65) was significantly higher than that in group A(87.69%, 57/65) and group B(86.1%,56/65), the difference being statistically significant(P<0.017). The time of fever relief, the of cough relief, the time of disappearance of lung rales and the time of subsiding of tonsil enlargement in group C　ｗｅｒｅ　ｓｉｇｎｉｆｉｃａｎｔｌｙ　ｓｈｏｒｔｅｒ　ｔｈａｎ　ｔｈｏｓｅ　ｉｎ　ｇｒｏｕｐ　Ａ　ａｎｄ　ｇｒｏｕｐ　B(P<0.05). The level of IgA, IgM and IgG in group C ｗａｓ　ｈｉｇｈｅｒ　ｔｈａｎ　ｔｈａｔ　ｉｎ　ｇｒｏｕｐ Ａ ａｎｄ Ｂ（P<０．０５）．　Ｔｈｅｒｅ　ｗｅｒｅ　ｎｏ　ｓｅｖｅｒｅ　ａｄｖｅｒｓｅ　ｒｅａｃｔｉｏｎｓ　ｉｎ　ｔｈｅ　ｔｈｒｅｅ　ｇｒｏｕｐｓ．　Ｉｎ　ｔｈｅ　ｏｎｅ-ｙｅａｒ　ｆｏｌｌoｗ-ｕｐ，　ｔｈｅ　ｒｅｃｕｒｒｅｎｃｅ　ｔｉｍｅｓ　ｏｆ　ｕｐｐｅｒ　ａｎｄ　ｌｏｗｅｒ　ｒｅｓｐｉｒａｔｏｒｙ　ｔｒａｃｔ　ｉｎｆｅｃｔｉｏｎ　ｉｎ　ｇｒｏｕｐ　Ｃ　ｗｅｒｅ　ｌｏｗｅｒ　ｔｈａｎ　ｔｈｏｓｅ　ｉｎ　ｇｒｏｕｐ　Ａ　ａｎｄ　Ｂ（P<０．０５）．Conclusion:Ｔｈｅ　ｅｆｆｅｃｔ　ｏｆ　ｐｉｄｏｔｉｍｏｄ　ｃｏｍｂｉｎｅｄ　ｗｉｔｈ　vｉｔａｍｉｎ　ＡＤ　ｄｒｏｐｓ　ｉｓ　ｅｆｆｅｃｔｉｖｅ　ｉｎ　ｔｈｅ　ｔｒｅａｔｍｅｎｔ　ｏｆ　ｃｈｉｌｄｒｅｎ　ｗｉｔｈ　ｒｅｃｕｒｒｅｎｔ　ｒｅsｐｉｒａｔｏｒｙ　ｔｒａｃｔ　ｉｎｆｅｃｔｉｏｎ，　ｗｈｉｃｈ　ｃａｎ　ｉｍｐｒｏｖｅ　ｔｈｅ　ｉｍｍｕｎｅ　ｆｕｎｃｔｉｏｎ，　ｐｒｏｍｏｔｅ　ｔｈｅ　ｒｅｌｉeｆ　ｏｆ　ｃｌｉｎｉｃａｌ　ｓｙｍｐｔｏｍｓ　ａｎｄ　ｒｅｄｕｃｅ　ｔｈｅ　ｒｅｃｕｒｒｅｎｃｅ　ｒａｔｅ　ｏｆ　ｔｈｅ　ｉｎｆｅｃｔｉｏｎ，　ｓｏ　ｉｔ　ｉｓ　ｗｏｒｔｈ　ｐｒｏｍｏｔｉｎｇ．

Key words: Recurrent respiratory tract infection, Pidotimod, Vitamin AD, Immune function, Children