关键词: 佝偻病, 诊断, 骨碱性磷酸酶, 儿童

Abstract:
Objective
To investigate the correlation between the diagnosis of rickets and the detection of bone alkaline phosphatase and the detection value.
Methods
A total of 62 cases of children with infantile rickets were selected in Hunan Children's Hospital who were hospitalized from October 2014 to January 2016 as the observation group，and another 62 cases of children with normal physical examination were selected at the same time in our hospital as the normal control group. The activity of bone alkaline phosphatase was detected by iodonitrotetrazole violet method；blood calcium was detected by azo arsenic method；the correlation between bone alkaline phosphatase and influential factors was analyzed.
Results
The detection rate of bone alkaline phosphatase abnormality in observation group was 96.77%(60/62)，which was significantly higher than that in normal control group(45.16%，28/62)，the difference being statistically significant(P<0.05); the detection rate of serum calcium abnormality in observation group was 22.58%(14/62)，which was significantly higher than that in normal control group(1.61%，1/62)，and the difference was statistically significant(P<0.05); Spearman correlation analysis showed that there was a positive correlation between seizure，picky eaters，sweating and lack of vitamin D and alkaline phosphatase activity(P<0.05).
Conclusion
The diagnosis of rickets in children is closely related to the activity of bone alkaline phosphatase，and the diagnosis of rickets can be completed by detection of bone alkaline phosphatase.

Key words: Rickets, Diagnosis, Bone alkaline phosphatase, Children