ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (6): 551-.

• 小儿中药应用研究 • 上一篇    下一篇

芩连止泻汤治疗小儿慢性腹泻的疗效观察

张艳，唐泓   

  1. 100074 北京，中国航天科工集团七三一医院儿科（张艳）；100038 北京，北京世纪坛医院儿科（唐泓）
  • 出版日期:2020-12-25 发布日期:2021-05-14
  • 通讯作者: 张艳，E-mail：1286425258@qq.com
  • 作者简介:张艳（1969-），女，医学硕士，主任医师。研究方向:小儿内科疾病的诊治

Observation on the therapeutic effect of Qinlian Zhixie decoction on chronic diarrhea in children

ZHANG Yan，TANG Hong   

  1. Pediatric Department of 731 Hospital of China Aerospace Science and Industry Group，Beijing 100074,China
  • Online:2020-12-25 Published:2021-05-14

PDF (PC)

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摘要： 目的：探讨小儿慢性腹泻临床治疗中选用芩连止泻汤的效果。
方法：选取2019年3月至2020年1月在本院诊治的慢性腹泻患儿76例作为研究对象，随机分为对照组和观察组各38例。对照组给予常规西药治疗，观察组加用中药芩连止泻汤治疗，观察患儿炎症控制、免疫功能改善、症状改善等情况。
结果：观察组治疗后白细胞介素-6、白细胞介素-10及肿瘤坏死因子α水平均低于对照组，差异有统计学意义（P<0.05）；治疗后观察组CD8+低于对照组，IgA、IgG及CD4+、CD4+/CD8+均高于对照组，差异有统计学意义（P<0.05）；治疗后观察组次症、主症中医证候积分及总积分均低于对照组，差异有统计学意义（P<0.05）；观察组临床总有效率为94.74%（36/38），高于对照组78.95%（30/38），差异有统计学意义（P<0.05）。
结论：在常规对症处理及西药治疗基础上再使用芩连止泻汤给予慢性腹泻患儿治疗，可有效提高炎症控制效果，更好调节患儿机体免疫功能，有助于提高总体治疗效果。

关键词: 慢性腹泻, 芩连止泻汤, 炎症反应, 免疫功能, 症状, 儿童

Abstract: Objective：To evaluate the effect of Qinlian Zhixie decoction in the clinical treatment of chronic diarrhea in children.
Methods：Totally 76 children with chronic diarrhea admitted to our hospital from March 2019 to January 2020 were randomly divided into two groups: the control group(38 cases) was treated with conventional western medicine，while the observation group(38 cases) was treated with Qinlian Zhixie decoction in addition to western medicine，and the inflammation control，immune function improvement and symptom improvement were observed.
Results：The levels of IL-6， IL-10 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05) after treatment; after treatment, CD8+ in the observation group was lower than that in the control group，while IgA，IgG and CD4+，CD4+/CD8+ were higher than that in the control group(P<0.05);after treatment，the TCM symptom score and total score of the observation group were lower than those of the control group，the difference being statistically significant(P<0.05). The total effective rates of the two groups were 94.74%(36/38) and 78.95%(30/38)，respectively(P<0.05).
Conclusion：On the basis of conventional symptomatic treatment and western medicine treatment，Qinlian Zhixie decoction, when used to treat patients with chronic diarrhea，can effectively improve the effect of inflammation control，better regulate the immune function of children，and help to improve the overall treatment effect.

Key words: Chronic diarrhea, Qinlian Zhixie decoction, Inflammatory reaction, Immune function, Symptoms, Child