ISSN 1674-3865 CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
辽宁省基础医学研究所
辽宁中医药大学附属医院
主管：国家卫生健康委员会
主办：中国医师协会
辽宁省基础医学研究所
辽宁中医药大学附属医院
中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (4): 358-.
目的: 观察益气化瘀清热方治疗小儿激素敏感型肾病综合征的疗效。
方法: 2017年7月至2018年7月在河南中医药大学第一附属医院及郑州儿童医院就诊门诊或住院的激素敏感型肾病综合征患儿69例，采用前瞻性队列研究方法，河南中医药大学第一附属医院门诊复查或住院的激素敏感型肾病综合征患儿在西药治疗基础上加用益气化瘀清热方者32例为观察组；郑州儿童医院门诊或住院西药治疗激素敏感型肾病综合征的患儿37例为对照组。对照组采用糖皮质激素治疗，观察组在糖皮质激素治疗基础上加用益气化瘀清热方，观察其在治疗前及治疗后2周、4周、8周、12周及36周的疗效和激素相关副作用。
结果: 疗程足2周时，观察组患儿完全缓解15例，部分缓解17例；对照组完全缓解6例，部分缓解28例，未缓解3例，观察组疗效优于对照组，差异有统计学意义（P=0.008)。36周治疗期间，观察组患儿复发率为12.5%（4/32），显著低于对照组患儿复发率为35.1%（13/37），差异有统计学意义（P=0.048)。观察组患儿感染发生率为31.3%（10/32），低于对照组59.5%（22/37），差异有统计学意义（P=0.029)；两组在激素导致的水牛背及满月脸副作用比较差异无统计学意义（P>0.05）。疗程8周后观察组汗出积分和烦躁积分明显低于对照组，差异有统计学意义（P<0.05）。
结论: 益气化瘀清热方具有缩短肾病综合征缓解时间，减少感染次数，降低复发率，减轻激素引起汗出及烦躁。
Objective: To observe the curative effect of Yiqi Huayu Qingre decoction on hormone-sensitive nephrotic syndrome in children.#br# Methods: A total of 69 outpatients or inpatients with hormone-sensitive nephrotic syndrome treated in the First Affiliated Hospital of Henan University of Chinese Medicine and Zhengzhou Children's Hospital from July 2017 to July 2018 were enrolled in this study. Prospective cohort study was used. The 32 outpatients or inpatients with hormone-sensitive nephrotic syndrome in the First Affiliated Hospital of Henan University of ChineseMedicine were treated with Yiqi Huayu Qingre decoction on the basis of western medicine(observation group), and the 37 children with hormone-sensitive nephrotic syndrome treated with western medicine in outpatient or inpatient department of Zhengzhou Children's Hospital were selected as the control group. The control group was treated with glucocorticoid, and the observation group was treated with Yiqi Huayu Qingredecoction on the basis of glucocorticoid. The efficacy and hormone-related side effects were observed before treatment and 2 weeks,4 weeks,8 weeks,12 weeks and 36 weeks after treatment.#br# Results:After 2 weeks of treatment, there were 15 cases of complete remission and 17 cases of partial remission in observation group. In the control group,6 cases were completely relieved,28 cases were partially relieved, and 3 cases were not relieved. The curative effect of the observation group was better than that of the control group, and the difference was statistically significant(P=0.008).During the 36-week treatment, the recurrence rate of the observation group was 12.5%(4/32),which was significantly lower than that of the control group(35.1%,13/37),and the difference was statistically significant(P=0.048).The incidence of infection in the observationgroup was 31.3%(10/32),which was lower than 59.5%(22/37) in the control group, and the difference was statistically significant(P=0.029).There was no significant difference in buffalo hump or moon facecaused by hormones between the two groups(P>0.05).After 8 weeks of treatment, the sweating score and irritability score of the observation group were significantly lower than those of the control group, and the differencewas statistically significant(P<0.05).#br# Conclusion: Yiqi Huayu Qingre decoction can shorten the remissiontime of nephrotic syndrome, reduce the number of infections, reduce the recurrence rate, and reduce the sweating and irritability caused by hormones.
摘要： 目的: 观察益气化瘀清热方治疗小儿激素敏感型肾病综合征的疗效。
方法: 2017年7月至2018年7月在河南中医药大学第一附属医院及郑州儿童医院就诊门诊或住院的激素敏感型肾病综合征患儿69例，采用前瞻性队列研究方法，河南中医药大学第一附属医院门诊复查或住院的激素敏感型肾病综合征患儿在西药治疗基础上加用益气化瘀清热方者32例为观察组；郑州儿童医院门诊或住院西药治疗激素敏感型肾病综合征的患儿37例为对照组。对照组采用糖皮质激素治疗，观察组在糖皮质激素治疗基础上加用益气化瘀清热方，观察其在治疗前及治疗后2周、4周、8周、12周及36周的疗效和激素相关副作用。
结果: 疗程足2周时，观察组患儿完全缓解15例，部分缓解17例；对照组完全缓解6例，部分缓解28例，未缓解3例，观察组疗效优于对照组，差异有统计学意义（P=0.008)。36周治疗期间，观察组患儿复发率为12.5%（4/32），显著低于对照组患儿复发率为35.1%（13/37），差异有统计学意义（P=0.048)。观察组患儿感染发生率为31.3%（10/32），低于对照组59.5%（22/37），差异有统计学意义（P=0.029)；两组在激素导致的水牛背及满月脸副作用比较差异无统计学意义（P>0.05）。疗程8周后观察组汗出积分和烦躁积分明显低于对照组，差异有统计学意义（P<0.05）。
结论: 益气化瘀清热方具有缩短肾病综合征缓解时间，减少感染次数，降低复发率，减轻激素引起汗出及烦躁。
