Table of Content

25 April 2021, Volume 13 Issue 2 Previous Issue   

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Clinical study of scalp acupuncture combined with transcranial ultrasound therapy and language training for children with mental retardation and language disorder WANG Xue 2021, 13 (2):  93.  Abstract ( 414 )   PDF (507KB) ( 427 )   Save Objective：To explore the effect of Scalp acupuncture with transcranial ultrasound therapy combined with language training in the treatment of children with mental retardation and language disorder. Methods：Totally 90 children with mental retardation and language disorder who were admitted to our hospital from June 1,2018 to December 31,2019 were selected as the study subjects. According to the order of admission, they were divided into test group, control group 1 and control group 2,30 cases each. Control group 1 was treated with traditional language cognitive training, Control Group 2 was treated with scalp acupuncture on the basis of language training, and test group was additionally treated with transcranial ultrasound therapy. Results：The intelligence level and language function of 3 groups were improved; the total effective rate of control group 2 was higher than that of control group 1, and the total effective rate of observation group was significantly higher than that of control group 1 and control group 2; all the differences were of statistical significance. Conclusion：Scalp acupuncture with transcranial ultrasound therapy combined with language training is significantly effective in the treatment of children with mental retardation and language disorder. Related Articles | Metrics

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Analysis of speech error pattern and intelligence structure in children with functional articulation disorders YAN Tingqi，GUAN Lijun 2021, 13 (2):  96.  Abstract ( 663 )   PDF (363KB) ( 84 )   Save Objective：To analyze the speech characteristics，error patterns and intelligence structure of children with functional articulation disorders，and to provide a basis for the development of speech rehabilitation programs. Methods：Forty children with functional articulation disorders were included as the observation group, who were treated in our hospital from Jan. 2018 to Jan. 2019, and 40 healthy children undergoing physical examination during the same period were included as the control group. The characteristics of speech error patterns in the observation group were analyzed, and the differences in the intelligence structure between the two groups were compared. Results：The error patterns in the articulation of initial consonants mainly included substitution, ellipsis and distortion, with substitution as the most common type, followed by ellipsis, and there was less distortion. The error rates of consonants l, ch, t, c and zh were all more than 70%. The error rates of en, ing, ong and ang in the vowels were over 15%; the error patterns were mainly substitution, and there was less ellipsis and distortion. There was no statistical difference in the scores of total intelligence quotient (IQ) or speech IQ between the two groups of children (P>0.05). The operational IQ of the observation group was lower than that of the control group (P<0.05). Conclusion：The speech error patterns in children with functional articulation disorders are mainly substitution, followed by ellipsis, and there is less distortion; most of them are initial consonants. There is developmental imbalance of intelligence structure in children with functional articulation disorders, and their operational ability is retarded. Related Articles | Metrics

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Effect of vitamin  B12 early intervention on DNA methylation and Aβ neurotoxicity of hippocampal neuron cells LIU Nairong，LI Jinghui，REN Gang，LI Jing，ZHAN Jie 2021, 13 (2):  99.  Abstract ( 577 )   PDF (852KB) ( 70 )   Save Objective：To explore the effect of vitamin  B12 supplementation in early life on DNA methylation level and Aβ toxicity in hippocampal neuron cells(HNCs) and its mechanism. Methods：HNCs in 12 h of birth of the newborn rats were taken for culture in vitro, which were randomly divided into 5 groups: blank group, model group, lowdosage vitamin  B12 group, medium-dosage group and high-dosage group. Different dosages of vitamin  B12 were given for intervention. HPLC method was used to determine the level of DNA methylation; meanwhile, observe the effect of early intervention by vitamin  B12 on proliferation rate(PR) and apoptosis rate(AR) of mature HNCs after Aβ1-42  toxification, MDA content, SOD activity and GSH-PX activity. Results：The DNA methylation level of HNCs intervened by vitamin  B12 at early stage was significantly lower than the control group(P<0.05);Aβ toxification could significantly decrease the PR and increase the AR of HNCs, and increase MDA content and reduce the activity of SOD and GSH-PX(P<0.05). Compared with model group, vitamin  B12supplementation in early life could increase PR of mature HNCs after Aβ toxification, decrease the AR, reduce MDA content, and increase the activity of SOD and GSH-PX, the difference being statistical((P<0.05). Conclusion:Supplementation of vitamin  B12  in early life is helpful to decrease the methylation level of neuron cells, which plays an anti-Aβ neurotoxicity role in mature neuron cells, participates in oxidative stress of neuron cells, promotes cell proliferation and slows down apoptosis of neuron cells. Related Articles | Metrics

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IDO expression in lung tissue and its relationship with IFN-γ in asthmatic mice XU Chunna，LI Xiao，TANG Yu，ZHANG Lei，WANG Xiufang 2021, 13 (2):  103.  Abstract ( 747 )   PDF (895KB) ( 80 )   Save Objective:To detect the expression of indoleamine 2,3-dioxygenase (IDO)in lung tissue and the level of interferon γ(IFN-γ) in serum and bronchoalveolar lavage fluid(BALF), and to explore the role of IDO in the pathogenesis of bronchial asthma and its relationship with IFN-γ. Methods:Select 21 SPF BALB/C mice. They were randomly divided into control group, intervention group and asthma group, with 7 mice in each group. A mouse model of asthma was established by sensitization and stimulation of dust mites extract. The changes of airway inflammatory cells were observed by hematoxylineosin staining; BALF was given cytological analysis; ELISA was used to detect IFN-γ levels in BALF; immunohistochemistry and Western Blot were used to detect IDO protein expression in lung tissue. Results:Asthma group: inflammatory cell infiltration, airway smooth muscle cell proliferation and lumen stenosis were obvious; intervention group: there were a small number of inflammatory cells infiltrating, there was airway smooth muscle cell proliferation, and lumen slightly narrowed; control group: there were no significant changes. The total number of cells, eosinophils and neutrophils in the BALF of asthma group were higher than those in the intervention group and the control group (P<0.05). The serum and BALF IFN-γ levels in asthma group were lower than those in intervention group and control group (P<0.05). The IDO gray value of lung tissue in asthma group was lower than that in control group and intervention group (P<0.05). IFN-γ level in serum was positively correlated with that in BALF(P<0.01), and expression of IDO protein in lung tissue was positively correlated with IFN-γ level in serum and BALF (P<0.01). Conclusion:There is a decrease in IDO protein expression in lung tissue of mice, which leads to deficiency and/or decrease of immune tolerance in vivo and promotes the development of bronchial asthma. Related Articles | Metrics

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Research progress in the relationship between simple obesity and thyroid function in children WANG Shijia，LIU Qingyang 2021, 13 (2):  108.  Abstract ( 671 )   PDF (511KB) ( 167 )   Save To explore the changes of thyroid hormones in children with simple obesity，and to provide theoretical basis for the treatment of simple obesity and improving the quality of life of obese children. Child obesity is closely related to changes in thyroid function. Obese children have higher levels of thyroid-stimulatinghormone(TSH) than ordinary children. The currently accepted hypothesis shows that its mechanism is related to leptin. A mild increase in TSH is more like an adaptive change in body weight， rather than a cause of obesity. Selective thyroid hormone receptor agonist may become a potential drug for the treatment of obesity in the future. It remains to be verified by more clinical studies whether it can be used in the treatment of childhood obesity. Related Articles | Metrics

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Research progress in the pathogenesis of autism spectrum disorders in children ZHAN Hong,BAI Shuxia,WANG Jintang 2021, 13 (2):  112.  Abstract ( 362 )   PDF (595KB) ( 167 )   Save Autism spectrum disorders(ASD) are a group of neurodevelopmental disorders characterized by social communication disorder,narrow interest or activity range and repetitive stereotyped behavior.Currently,the prevalence of ASD has been increasing year by year at home and abroad.The high-risk factors of ASD are the research focus at home and abroad,and the pathogenesis is the difficulty of current research.This article reviews the pathogenesis of high-risk factors of autism spectrum disorders from three levels:genetic molecule,cell tissue and human body,in order to provide reference for better cognition and early intervention of ASD. Related Articles | Metrics

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New progress and clinical application of allergen detection LI Yixian，YANG Jun，XIA Yu 2021, 13 (2):  117.  Abstract ( 385 )   PDF (626KB) ( 172 )   Save Allergen detection is an important method in the diagnosis and evaluation of allergic diseases.Classical detection methods such as skin tests and IgE in vitro tests are developing in the direction of more allergens,less blood samples and higher accuracy;meanwhile，the new detection like cellular and molecular diagnosis are developing rapidly.In order to provide better clinical decisionmaking for clinicians who are facing complicated detection methods,this article reviews the common allergen detection methods in vivo and in vitro,introduces their indications,advantages and disadvantages as well as their clinical application in various types of allergic diseases and different groups of people. Related Articles | Metrics

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Application of wholism in rehabilitation of children with cerebral palsy LI Haifeng，SHAO He，DU Xiubo 2021, 13 (2):  121.  Abstract ( 298 )   PDF (430KB) ( 129 )   Save Through the specific analysis and summary of the concept of wholism applied in the rehabilitation of children with cerebral palsy, this paper is aimed to discuss the application and practical guiding significance of the concept of wholism in the rehabilitation of children with cerebral palsy. Based on the modern rehabilitation medical model of "biology-psychology-society-nature", the concept of wholism is embodied in the rehabilitation of children with cerebral palsy, which also guides the development of rehabilitation theory and the clinical application. The concept of wholism can be applied to the whole process of rehabilitation of children with cerebral palsy, which has practical guiding value. Related Articles | Metrics

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Meta-analysis of massage in the treatment of recurrent respiratory tract infection in children YANG Lili，LI Jilei，WANG Panpan,LIU Xiaowei，ZHANG Yan 2021, 13 (2):  124.  Abstract ( 511 )   PDF (5507KB) ( 250 )   Save Objective:To systematically evaluate the clinical efficacy of massage manipulation or combined with conventional therapy in the treatment of recurrent respiratory tract infections(RRTI) in children. Methods:To search the literature on children′s RRTI treated by massage,China Knowledge Network,Wanfang,Weipu,PubMed、The Cochrane Library、EMbase,The retrieval time is from self-built library to June 2020.Two researchers assisted each other,According to the inclusion and exclusion criteria,Use Revman 5.3 for Meta analysis. Results:17 papers were selected,A total of 1 858 cases,Treatment group 931 cases,Control group 927 cases.The total effective rate of treatment group was higher than that of control group(OR=4.66,95%CI（3.39，6.40）,P<0.000 01),The treatment group was superior to the control group in improving IgA、IgG、IgM、CD3、CD4 and CD4/CD8 levels,There were statistical differences，but showed no statistical significance in improving CD8. Conclusion:The available evidence shows that the use of massage manipulation or massage combined with conventional therapy is effective in the treatment of RRTI in children,better than western medicine oral or intravenous drip,blank control or simulant treatment. Related Articles | Metrics

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Randomized controlled trial and Meta-analysis of the therapeutic effect of Maxing Shigan decoction combined with azithromycin on Mycoplasma pneumoniae pneumonia in children JIANG Hui，ZHENG Xin，ZENG Yanmin，MA Yuping，PENG Wenyu. 2021, 13 (2):  131.  Abstract ( 570 )   PDF (4078KB) ( 117 )   Save Objective:To systematically evaluate the efficacy and safety of Maxing Shigan decoction combined with azithromycin in the treatment of Mycoplasma pneumoniae pneumonia in children. Methods:By searching the databases of PubMed, Cochrane Library, CNKI, VIP, Wanfang and CBM, the randomized controlled trials(RCT) on Maxing Shigan decoction combined with azithromycin in the treatment of Mycoplasma pneumoniae pneumonia(MPP) in children were included. The retrieval time was from January 1998 to March 2020. Two researchers independently screened the literature, extracted data and evaluated the quality according to the inclusion and exclusion criteria, and then Revman 5.3 and Stata 15.0 were used for Meta-analysis. Results:Totally 22 RCTs were included, involving 2 887 subjects. The results of Meta-analysis showed that the combination of Maxing Shigan decoction with azithromycin could improve the clinical efficacy［OR=6.26,95%CI(4.75,8.26),P<0.000 01］and reduce the adverse reactions［MD=0.25,95%CI(0.13,0.50),P<0.000 01］, as compared with azithromycin alone. Regarding the improvement of the clinical symptoms and signs, including the time of fever relief, the time of cough disappearance, the time of lung rales disappearance, and the time of the disappearance of lung X-ray erosion shadow, the effect of Maxing Shigan decoction combined with azithromycin was better than that of azithromycin alone. The above differences were statistically significant(P<0.05). Conclusion:Maxing Shigan decoction combined with azithromycin can improve the clinical efficacy on and the symptoms of Mycoplasma pneumoniae pneumonia in children. However, due to the limited quantity of trials included and the poor quality of the methodology, high-quality and large-sample randomized controlled trials are needed to confirm the results.  Related Articles | Metrics

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Changes of serum PCT, CRP and IL-6 levels in pediatric bone and joint infections and their clinical significance YANG Jiali, ZHAI Manman, LI Zhihao 2021, 13 (2):  138.  Abstract ( 540 )   PDF (465KB) ( 112 )   Save Objective:To explore the changes in the levels of serum procalcitonin(PCT), C-reactive protein(CRP) and interleukin-6(IL-6)，and their clinical significance in pediatric bone and joint infections. Methods:Ninety child patients with bone and joint infections who were treated in Children's Hospital Affiliated to Zhengzhou University from December 2015 to December 2017 were included as case group. Another 90 healthy children with physical examination during the same period were selected as control group. The levels of serum PCT, CRP and IL-6 were measured. The levels of serum PCT, CRP and IL-6 in case group and control group were statistically analyzed. The levels of serum PCT, CRP and IL-6 among child patients with different types of bone and joint infections were statistically analyzed. The levels of serum PCT, CRP and IL-6 among children in acute infection and recovery phase were statistically analyzed. The levels of serum PCT, CRP and IL-6 among child patients with different disease severity were statistically analyzed. Results:The levels of serum PCT, CRP and IL-6 in case group were higher than those in control group (P<0.05).The serum levels of PCT, CRP and IL-6 in child patients with suppurative arthritis were higher than those in child patients with acute osteomyelitis and chronic osteomyelitis (P<0.05). The serum levels of PCT, CRP and IL-6 of child patients with bone and joint infections in acute infection phase were higher than those in recovery phase (P<0.05). The serum levels of PCT, CRP and IL-6 in child patients with severe infections were higher than those in child patients with mild infections (P<0.05). Conclusion:The serum levels of PCT, CRP and IL-6 are of important significance in clinically evaluating conditions of children with bone and joint infections.  Related Articles | Metrics

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Effect of Salvia on ACTA and S-100B protein in CSF of children with HFMD and encephalitis YANG Lin， QI Nannan，ZOU Wenchao 2021, 13 (2):  141.  Abstract ( 196 )   PDF (407KB) ( 55 )   Save Objective:To investigate the effect of Salvia on ACTA and S-100B protein in CSF of children with HFMD and encephalitis. Methods:A total of 76 children with HFMD and encephalitis treated in our hospital from Aug. 2014 to July 2019 were divided into two groups: the observation group and the control group. The control group was given routine comprehensive treatment. The treatment group was treated with Salvia on the basis of routine comprehensive treatment. Both groups were treated for 10 days. The clinical effect and the indexes of ACTA and S-100B in CSF of the two groups were compared. Results:After treatment，the consciousness recovery，convulsion control and the control of intracranial hypertension in the treatment group were better than those in the control group，and the ACTA and S-100B indexes of CSF in the treatment group were significantly lower than those in the control group(P<0.05). Conclusion:Salvia can improve the clinical symptoms of HFMD with encephalitis and reduce the inflammatory damage. Related Articles | Metrics

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Study on the correlation of Five-Yun-Six-Qi at birth with pathological types of children with nephrotic syndrome ZENG Weijia，CHEN Naiqing，WEN Xiaoying，ZHANG Lijiao 2021, 13 (2):  144.  Abstract ( 211 )   PDF (529KB) ( 48 )   Save Objective:To compare the natures of Five-Yun-Liu-Qi of the birth dates of children with focal segmental glomerulosclerosis(FSGS) with those of children with minimal change disease(MCD), and to explore the internal relationship and differences between the natural endowment and pathological types under the influence of Five-Yun-Six-Qi, so as to provide theoretical reference for clinical judgment of prognosis and prediction of pathological types. Methods:A total of 54 patients with focal segmental glomerulosclerosis(n=18,FSGS group) or minimal change disease(n=36,MCD group) were selected from the pediatric inpatients, who were confirmed by renal puncture in Guangdong Provincial Hospital of Traditional Chinese Medicine from 2005 to 2019. The complete information of birth date of the patients was collected, and the natures of Five-Yun-Six-Qi were analyzed and compared between the two groups. Results:There were significant differences between the two groups in the distribution of the Fire-Yun of Sui-Yun and the Water-Yun of Ke-Yun between the two groups(P<0.05).In the comparison of the Fire-Yun of Sui-Yun, the FSGS group tended to be in deficiency of Fire-Yun, while the MCD group tended to be in excess of Fire-Yun. As for Ke-Yun, FSGS group tended to be excessive in Water-Yun, while MCD group tended to have deficiency in Water-Yun. Conclusion:FSGS should be considered if there is deficiency in Fire-Yun and excess in Water-Yun, which also suggests that the prognosis may be poor. Related Articles | Metrics

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The early diagnostic value of neutrophil gelatinase-associated lipocalin in neonatal asphyxia with acute kidney injury FENG Xiao，TIAN Weimin，CHEN Ling，ZHAO Hongying 2021, 13 (2):  148.  Abstract ( 770 )   PDF (419KB) ( 86 )   Save Objective:To detecting the changes of neutrophil gelatinase-associated lipocalin（NGAL） in umbilical cord blood，serum and urine in asphyxiated neonates Acute kidney injury，explore the diagnostic value of NGAL in neonatal asphyxia acute kidney injury. Methods:72 patients with Asphyxia neonatorum in our hospital from 2018 to 2019 were collect as research objects，Detection the umbilical cord blood after birth.Serum NGAL(sNGAL)，serum creatinine (sCr)，urine NGAL and urine creatinine were measured on the first and third day after birth.According to whether acute renal injury occurs within 7 days after birth，it is divided into acute kidney injury group (AKI group) and non acute kidney injury group (non AKI group) . Results:The NGAL level of umbilical cord blood in AKI group was higher than that in non AKI group(P<0.01)，The levels of sNGAL and uNGAL/UCR in AKI group were higher than those in non AKI group on the first day after birth(P<0.01)，The levels of sNGAL and uNGAL/UCR in AKI group were higher than those in non AKI group on the third day after birth(P<0.01)，There was no significant difference in the level of sCr between AKI group and non AKI group on the first day(P>0.05)， the level of sCr in AKI group was higher than that in non AKI group in the third day after birth(P<001).The AUC values of umbilical cord blood，serum and urine NGAL in asphyxiated neonates Acute kidney injury were 0.83（95％CI 0.74-0.91）、0.90（95％CI 0.86-0.94）、0.81（95％CI 0.67-0.95），The critical value of serum NGAL concentration was 119 μg/L,and the sensitivity was 88% and the specificity was 87%. Conclusion:The concentration of umbilical cord blood NGAL，serum NGAL and urine NGAL can reflect the neonatal asphyxia acute kidney injury，which have high clinical application values. Related Articles | Metrics

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Application of angiopoietin 2 in children with sepsis and lung injury CHEN Yanying, LUO Lan, LONG Caixia 2021, 13 (2):  152.  Abstract ( 186 )   PDF (375KB) ( 41 )   Save Objective:To study the changes and clinical significance of angiopoietin 2 in the serum of children with sepsis and lung injury. Methods:A total of 90 children with sepsis treated in our hospital from July to December of 2019 were included in the study, who were divided into two groups based on the severity of disease: 63 in the sepsis group and 27 in the septic shock group. Another 30 children undergoing physical examination during the same period were chosen as the control group. Among the 90 children with sepsis, 25 had lung injury. The level of angiopoietin 2 was observed in the three groups and in the children with sepsis and lung injury. Results:(1) The level of angiopoietin 2 in the sepsis group and septic shock group was significantly higher than that in control group (P<0.05). The level of angiopoietin 2 in sepsis group was significantly lower than that in septic shock group (P<0.05). (2) The level of angiopoietin 2 in the children with sepsis and lung injury was significantly higher than that in the septic children without lung injury (P<0.05). Conclusion:Angiopoietin 2 has become an important biomarker in clinical determination of sepsis. It can not only indicate the disease severity but also predict the occurrence of sepsis and lung injury at an early stage, which provides support for the following clinical treatment. Related Articles | Metrics

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Related factors of recurrence in children during epilepsy remission after drug reduction and withdrawal LU Fangfang，CUI Weiwei，CAO Miaomiao 2021, 13 (2):  155.  Abstract ( 424 )   PDF (292KB) ( 62 )   Save Objective：To explore and analyze the disease recurrence in children during epilepsy remission within 2 years after drug reduction and withdrawal,and to analyze the related factors that induce recurrence. Methods：A total of 168 children during epilepsy remission after anti-drug treatment in our hospital from March 2016 to March 2018 were followed up.Their clinical data were retrospectively analyzed.The related factors that caused epilepsy recurrence were analyzed. Results：In the 2 years of follow-up,there were 40 recurrence cases in the 168 children,with recurrence rate being 23.81%.The following factors,including age younger than 6 years old,course of disease no shorter than 1 year before treatment,persistent epilepsy before treatment,intracranial lesions,AEDs treatment cycle no shorter than 1 year,epileptic discharge before drug reduction and withdrawal,drug reduction and withdrawal shorter than 6 months and abnormal EEG manifestations before drug reduction and withdrawal,were risk factors of recurrence. Conclusion：Clinically,drug reduction and withdrawal should follow the principle of individualization in epilepsy children.Taking targeted intervention measures for high-risk factors helps to reduce the recurrence rate after drug reduction and withdrawal in children during remission. Related Articles | Metrics

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Clinical study on the adjuvant treatment for children with tonsillitis(wind-heat invading lung type) by Yi Guan DUAN Xiaozheng，MENG Xiangyue 2021, 13 (2):  158.  Abstract ( 370 )   PDF (381KB) ( 53 )   Save Objective：To explore the clinical effect of Yi Guan in the treatment of children with tonsillitis(windheat invading lung type). Methods：A total of 60 children with tonsillitis (wind-heat invading lung type) were selected and randomly divided into observation group and control group with 30 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Yi Guan adjuvant therapy on the basis of conventional western medicine. Both groups were treated for a course of 7 days. The clinical efficacy of the two groups was observed. Compare the following items between the two groups before and after treatment: the total score of TCM syndrome, the improvement score of sore throat and tonsil enlargement, and the time of body temperature, sore throat and abscess to be relieved. Results：The total effective rate of the observation group was better than that of the control group, and the difference was statistically significant(P<0.05). After treatment, the total TCM syndrome score, improvement score of sore throat, and improvement score of tonsil enlargement in the observation group were lower than those in the control group, with statistical difference(P<0.05). The recovery time of body temperature, the relief time of sore throat and the subsidence time of pus in the observation group were all shorter than those in the control group, and the differences were statistically significant（P＜0.05）. Conclusion：The clinical application of Yi Guan as an adjutant treatment for children with tonsillitis(wind-heat invading lung type) has significant effect and can be popularized. Related Articles | Metrics

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Professor Liu Xia's experience in the treatment of Tourette syndrome in children by regulating the lung and calming the liver CHEN Tuanying，LI Jing，WU Wenxian，LIU Xia 2021, 13 (2):  161.  Abstract ( 976 )   PDF (481KB) ( 118 )   Save  recent years, the incidence rate of Tourette syndrome in children has been increasing year by year, which seriously affects the children's physical and mental health as well as their quality of life. Professor Liu Xia, one in the sixth group of academic experience instructors of national experts in traditional Chinese medicine, has rich clinical experience in the treatment of Tourette syndrome in children. Based on her many years of clinical experience, she proposed the views that the pathogenesis of Tourette syndrome in children is "rooting in the liver, onset in the lung", establishing her theories from "wind evil and phlegm evil", and adopted the method of regulating lung and calming liver as well as dispelling wind and removing phlegm to treat Tourette syndrome in children. She used Lily magnolia,Periostracum cicadae,Rhizoma phragmitis,Folium isatidis,Rabdosia rubescens,papaya,Pinellia ternate,Common clubmoss herb,Ramulus uncariae cum unicis and scorpion as the basic drugs and according to different characteristics of the symptoms she adjusted the medicines during the treatment of children with Tourette syndrome, and the effect was satisfactory. She believed that the disease's onset was slow and its recovery was not quick. As for the principle of therapeutic methods, the most important thing was to stick to the law and prescription, and to follow the prescription if the effect was good, maintaining the treatment. In addition, life conditioning during the treatment was very important, we should pay attention to daily life, diet and psychological care,and focus on the prevention of respiratory tract infection in order to dispel the causes of the disease. Related Articles | Metrics

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Professor Peng Yu's application of activating blood circulation in children's pneumonia asthma KUANG Bumin，PENG Yu，LIU Qiyan，GAO Na，HUANG Geyan，PANG Ping 2021, 13 (2):  164.  Abstract ( 189 )   PDF (656KB) ( 81 )   Save This paper summarizes Professor Peng Yu's experience in clinical diagnosis and treatment of children with pneumonia asthma based on the theoretical basis of blood stasis and the blocking of lung collaterals and blood stasis, which means making a differential treatment for pneumonia asthma by flexibly applying the method of "activating blood circulation". By sorting Professor Peng Yu's experience and theory and giving examples of the cases of pneumonia asthma treated by this method, this paper presents an effective theoretical and clinical method for the treatment of children with pneumonia asthma by the method of "activating blood circulation". Related Articles | Metrics

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Shi Yumin′s experience in the treatment of chronic pharyngitis in children SUN Yanyan，WANG Yonghong，SUN Wen，SHI Yumin 2021, 13 (2):  168.  Abstract ( 435 )   PDF (443KB) ( 90 )   Save Chronic pharyngitis in children belongs to the category of Pharyngitis in Traditional Chinese Medicine according to its clinical manifestation.It is more common with pharyngitis of asthenic-fire，which is mostly due to the reoccurrence of acute throat paralysis，resulting in disfunction of viscera and inflammation caused by deficiency fire.Professor Shi believes that combined with the children′s physical characteristics，syndrome of intermingled deficiency and excess is the most common type in chronic pharyngitis for children，which is mainly related to the congenital weakness of Lung，Spleen as well as Kidney，and acquired imbalance of qi，blood，yin and yang result from losing care after birth.Whether the therapy is based on deficiency and excess of viscera and the treatment of yin，yang，qi and blood，the therapeutic principle of it should be focused on addressing both the manifestation and root cause as well as strengthening body resistance and eliminating evil. Related Articles | Metrics

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Chang Ke's clinical experience in the treatment of children with cough by Xinma decoction through the therapy of combining cold medicine with hot medicine LUO Xin，CHANG Ke，SUN Xiangjuan，FENG Dandan 2021, 13 (2):  170.  Abstract ( 524 )   PDF (502KB) ( 56 )   Save Clinically, the differentiated prescription based on the "eight principles" is often used in the treatment of children with cough. But many mixed /miscellaneous syndromes are observed in clinical practice, in which it is difficult to distinguish the exterior from the interior or the cold from the heat. In clinical treatment, the selfmade Xinma decoction by professor Chang Ke was used based on the principle of combining cold medicine with hot medicine，and prepared new ephedra prescription for treatment, which has been proved clinically effective。 Related Articles | Metrics

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Clinical study of modified asthma tonifying ointment combined with Sanfu plaster in the treatment of childhood asthma in remission stage JIA Xue，JIN Yunjiao，ZHAO Qiong，LIAO Min，ZHOU Hongyun，LIU Qianwei 2021, 13 (2):  173.  Abstract ( 840 )   PDF (467KB) ( 69 )   Save Objective：To observe the clinical efficacy of modified asthma tonifying ointment combined with Sanfu plaster in the treatment of children with asthma in remission stage. Methods：A total of 70 children with asthma in remission stage treated from August 2017 to June 2018 in Sichuan Hospital of Traditional Chinese Medicine were selected and randomly divided into control group(n=34) and observation group(n=36).The control group was treated with inhaled budesonide suspension and oral montelukast sodium chewable tablets,while the observation group was treated with oral asthma tonifying ointment with modification and Sanfu plaster.The course of treatment was 3 months.After treatment,the clinical effects of the two schemes were compared in terms of control level of asthma symptoms,lung function,TCM symptom score,TCM syndrome efficacy and safety. Results：After treatment,there were 6 cases lost in observation group and 4 in control group.There was no significant difference in the control level of asthma symptoms or the time of nonwheezing symptoms between the two groups(P>0.05).In terms of pulmonary function,the PEF values of the two groups after treatment were lower than those before treatment,and the difference was statistically significant(P<0.05);there was no significant difference in PEF value between the two groups after treatment（P>0.05）.After treatment,the total score of TCM symptoms in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the TCM symptom scores of repeated colds,spontaneous sweating,poor appetite and abnormal stool in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate in the observation group was 96.7%(29/30),which was significantly higher than that in the control group(43.3%,13/30),and the difference was statistically significant(P<0.05).There was no obvious adverse reaction during and after treatment with asthma tonifying ointment combined with Sanfu plaster for lung and spleen qi deficiency syndrome in children with asthma in remission stage. Conclusion：Modified asthma tonifying ointment combined with Sanfu plaster is effective and safe in the treatment of children with asthma in remission stage. Related Articles | Metrics

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Clinical observation of modified Xiaoqinglong decoction in the treatment of children with cough variant asthma of external cold and internal fluid type WAN Jun,YU Zhou,SUN Mengtian,YANG Xiangzheng 2021, 13 (2):  177.  Abstract ( 809 )   PDF (523KB) ( 86 )   Save Objective：To observe the clinical effect of modified Xiaoqinglong decoction combined with fluticasone propionate inhaled aerosol in the treatment of cough variant asthma of external cold and internal fluid type. Methods：A total of 80 patients with cough variant asthma of external cold and internal fluid type were included and randomly divided into observation group(n=40)and control group(n=40). The observation group was treated with modified Xiaoqinglong decoction combined with fluticasone propionate inhaled aerosol, while the control group was treated with fluticasone propionate inhaled aerosol alone, and the treatment period was 1 month. The scores of TCM symptoms, clinical efficacy and recurrence rate of each group were observed. Results：The total effective rate of the observation group and the control group was 95.0%(38/40) and 75.0%(30/40), respectively, with significant difference between the two groups(P<0.05). After treatment, the scores in wheezing, cough and expectoration of the control group were significantly higher than those of the observation group(P<0.05). After stopping the treatment, the recurrence rate in observation group was 10.0%(4/40), lower than that of control group(27.5%,11/40)(P<0.05). Conclusion：Modified Xiaoqinglong decoction combined with fluticasone propionate inhaled aerosol has significant effect in the treatment of cough variant asthma of external cold and internal fluid type, which can significantly improve the clinical symptoms and reduce the recurrence rate. Related Articles | Metrics

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Analysis of distribution characteristics of rare diseases in Henan Children's Hospital from 2015 to 2019 ZHANG Yaodong,LUO Shuying,CHEN Yongxing，TAN Lina，WEI Haiyan 2021, 13 (2):  180.  Abstract ( 762 )   PDF (649KB) ( 78 )   Save Objective：To analyze the distribution characteristics of inpatients with rare diseases in Henan Children's Hospital, and provide scientific basis for the epidemiological study of rare diseases in children. Methods：The medical records of 1 104 rare disease patients admitted to Henan Children's Hospital from 2015 to 2019 were selected for descriptive epidemiological research and analysis. Results：The average age of patients with rare diseases was 30.87 months, and the average age was in the age range of 28.97 to 32.77 months, and the age distribution showed an increasing trend from 2015 to 2019. The types of common rare diseases in children were different in each period. The main types of rare diseases in infants, early childhood, and preschool children were methylmalonic acidemia and congenital adrenal hyperplasia, while the main rare diseases in schoolage children were congenital adrenal hyperplasia，and hepatolenticular degeneration. The top three rare disease types were methylmalonic acidemia, congenital adrenal hyperplasia, and hyperammonemia, which accounted for 31.7%(350/1 104), 21.7%(240/1 104) and 7.4%(82/1 104), respectively in rare disease patients. Among different types of rare diseases, the ratio of men to women was quite different. The top five rare diseases with the highest ratio of men to women were in turn as follows: adrenal leukodystrophy, glutaric acidemia, phenylketonuria, Kalman syndrome, and biotin-dependent hydroxylase deficiency. The top five rare diseases with the lowest male to female ratio were in turn as follows: multiple fibrous dysplasia with precocious puberty syndrome, Wadenberg syndrome, congenital hyperinsulinemia, type II glycogen storage disease, and Niemann-Pick's disease. Conclusion：From 2015 to 2019, the age distribution of rare diseases in Henan Children's Hospital showed an increasing trend year by year, and the main types of rare diseases in children were also different in different age groups. The ratio of men to women with different types of rare diseases is quite different. Related Articles | Metrics