Table of Content

25 February 2021, Volume 13 Issue 1 Previous Issue    Next Issue

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Role of miRNAs in the model of asthma in mice ZHANG Dongjiao，XU Hao 2021, 13 (1):  1.  Abstract ( 257 )   PDF (714KB) ( 57 )   Save Objective：To investigate the differential expression of miRNAs in asthma model of mice. Methods：BALB/c mice were randomly divided into normal control group， asthma group(ovalbumin treatment group) and treatment group(dexamethasone treatment group)， 8 mice in each group. Eosinophil(EOS)， neutrophil(NEU)， macrophage(MAC) and lymphocyte(LYM) in BALF of each group were detected by hematology analyzer, and the expression of IL-4，IL-6 and IL-13 in BALF of each group were detected by ELISA. miRNAs microarray was used to analyze the differential expression of miRNAs in different groups of lung tissues; the correlation between miR-455 and EOS，NEU，MAC，LYM，IL-4，IL-6 and IL-13 was statistically analyzed. Results：The expression of EOS，NEU，MAC，LYM，IL-4，IL-6 and IL-13  in the asthma group was significantly higher than that in the control group, and the expression of various factors was downregulated in treatment group compared with asthma group. The expression of multiple miRNAs in asthma group changed，and miR-455 was up-regulated significantly in asthma group. miR-455 was positively correlated with the expression of EOS，NEU，MAC，LYM，IL-4，IL-6 and IL-13. Conclusion：miR-455 is significantly up-regulated in ovalbumin-induced asthma model of mice. Related Articles | Metrics

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New advances in the interactions between genes and environment in the pathogenesis of asthma in children CHEN Haixia，SHAN Yuxia，CUI Zhenze，I Lei 2021, 13 (1):  5.  Abstract ( 172 )   PDF (651KB) ( 63 )   Save In the global scope，the morbidity and mortality of bronchial asthma in children is increasing. The main causes include both the genetic factors and the environmental factors，especially the interaction between them. Epigenetics brings about the gene mutation through the environmental factors，which can be passed on to the next generation. It is an important factor of the higher incidence of bronchial asthma in children. Epigenetic modification not only affects the prevalence of asthma but may also affect the control level of asthma. Understanding the characteristics of interaction between genetic factors and environmental factors，especially the epigenetic characteristics，can provide new ideas for the early diagnosis and early intervention of childhood bronchial asthma. Related Articles | Metrics

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Effect of acupuncture therapy for invigorating the kidney and strengthening brain in the adjuvant treatment of children with cerebral palsy and its influence on language development quotient and comprehensive function ZHANG Xueyan，FU Jiena，GAO Lijuan. 2021, 13 (1):  10.  Abstract ( 115 )   PDF (437KB) ( 61 )   Save Objective:To explore the effect of acupuncture therapy for invigorating the kidney and strengthening brain combined with language group training in the treatment of children with cerebral palsy(CP) and its influence on language development quotient and comprehensive functions. MethodsA: total of 84 children with cerebral palsy who were treated in our hospital from June 2016 to June 2019 were selected and randomly divided into a control group and an observation group with 42 cases each. Both groups were given language group training, and the observation group also received acupuncture therapy for invigorating kidney and strengthening brain. The clinical effects, language development quotient score and comprehensive function score of the two groups of children with cerebral palsy were observed Results:The total effective rate of the observation group was 83.33%(35/42), which was significantly higher than that of the control group 54.76%(23/42), and the difference was statistically significant(P<0.05); after 3 months of treatment, language development quotient score, and the scores of cognitive function, motor function, selfcare function and social adaptation in observation group were significantly higher than those of the control group, and the difference was statistically significant(P<0.05). Conclusion:Acupuncture therapy for invigorating the kidney and strengthening brain combined with language group training is effective in the treatment of children with cerebral palsy, which can increase language development quotient and improve comprehensive functions. Related Articles | Metrics

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Professor Zhu Jinshan's experience in the treatment of Henoch-Schnlein purpura：report of some cases PENG Baoli，GUO Zhengzhen 2021, 13 (1):  14.  Abstract ( 246 )   PDF (468KB) ( 56 )   Save Henoch-Schnlein purpura(HSP) is an allergic disease mainly involving capillaries and small arteries and veins. Professor Zhu Jinshan has unique clinical opinions on the treatment of allergic purpura and other pediatric difficult and miscellaneous diseases with pure Chinese medicine, which has achieved great effect. It is suggested that the etiology and pathogenesis of this disease are the exogenous six evils and heat underlying evils. At the early stage of differentiated treatment the first thing is to cool and disperse blood heat，and pay attention to the discharge of evils; at the middle stage，when clearing heat and cooling blood，we should take care of the Yin fluid，and at the later stage，Both attack and complement should be carried out，and we should not forget to clear the residual heat. Based on case analysis，this paper summarizes Professor Zhu's experience in the treatment of children with Hencch-Schonlein purpura.  Related Articles | Metrics

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Research in the nutritional status and serum mineral content of children with autism spectrum disorder LI Na，LI Xiaofeng，WANG Yang，WEI Huanping，LI Ou，ZHAO Xusheng 2021, 13 (1):  17.  Abstract ( 135 )   PDF (631KB) ( 61 )   Save Objective:To evaluate the nutritional status of children with autism spectrum disorder(ASD) and the content of 11 minerals in serum. Methods:126 children who were diagnosed with ASD in Shenyang Children's Hospital from January to December，2019 were selected as the ASD group，and another 200 children who were examined in the Child Healthcare Department of Shenyang Children's Hospital during the same period were selected as the control group. The contents of calcium，iron，zinc，selenium，magnesium，copper，manganese，lithium，cobalt，nickel and mercury in serum were determined by Inductively coupled plasma mass spectrometry(ICP-MS). Results:The incidence of low body weight in ASD group was (8.7%, 11/126), higher than that in control group (2.5%, 5/200)，and the difference was statistically significant (P<0.05). Serum zinc/copper，selenium and lithium in ASD group were lower than those in control group, while copper，manganese and mercury were higher than the control group（P<0.01）. Conclusion:ASD children have deficiency of trace elements lithium and selenium，and excess of heavy metals copper and mercury. Clinicians should pay attention to the balance of minerals in ASD children，and provide dietary intervention and nutrition guidance to ASD children.  Related Articles | Metrics

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Clinical characteristics and immune mechanism of refractory Mycoplasma pneumoniae pneumonia in children LIU Yuemei, ZHANG Lei,ZHAO Eryao, WANG Jing, DONG Lili. 2021, 13 (1):  21.  Abstract ( 201 )   PDF (446KB) ( 57 )   Save Objective:To study the clinical characteristics and immune mechanism of refractory Mycoplasma pneumonia pneumonia(RMPP) in children. Methods:A total of 97 RMPP children treated in our hospital from March 2017 to March 2019 were included as the observation group, and they were divided into severe RMPP group and mild RMPP group. According to the ratio of 1∶2, 46 children with common pneumonia in the same period were included as the control group. Flow cytometry was used to determine the level of T cell subsets in bronchoalveolar lavage fluid; enzyme linked immunosorbent assay was used to determine the level of interleukin-5(IL-5), IL-6, tumor necrosis factor α (TNF-α) and sB7-H3; the differences in them were analyzed. Results:The level of CD3 and CD4 and value of CD4/CD8 in severe RMPP group was (45.7±8.6)%，（20.4±6.5）% and 0.97±0.14, which were significantly lower than those of mild RMPP group and control group, and the differences were statistically significant(P<0.05). The CD8 level was (20.6±3.3)% in severe group, which was not statistically different from that in mild group ［(22.3±4.7)%(P>0.05). The level of IL-5，IL-6 and TNF-α in severe RMPP group was (18.7±3.2)ng/L, (27.2±1.3)ng/Land (112.7±13.5)ng/L, respectively, which was significantly higher than that in mild RMPP group and control group(P<0.05). The level of sB7-H3 expression was 132.7 ng/L, significantly higher than that of control group(P<0.05), but it was not statistically different from that of mild group(P>0.05) Conclusion:IL-5，IL-6, TNF-α and sB7-H3 are all involved in the disease progression of RMPP, which is manifested by the disorder of CD3, CD4 and CD4/CD8 of T cell Subsets, affecting the immune function of human body and aggravating the disease.  Related Articles | Metrics

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Analysis of the risk factors for occurrence of 402 cases of low birth weight infants in Dalian LIU Mingtao, HUANG Yan, CUI Zhenze 2021, 13 (1):  25.  Abstract ( 328 )   PDF (406KB) ( 40 )   Save Objective:To study the risk factors for low birth weight infants(LBWI) during pregnancy and pregnancy periods in Dalian. Methods:A total of 402 cases of LBWI, born in Dalian from Apr. 2012 to Oct. 2019, were divided into 3 groups according to their birth weights:8 cases in ELBWI group (≤1 000 g), 70 cases in VLBWI group(1 001-1 500 g), and 324 cases in LBWI group (1 501-2 500 g). IMOCH infant high-risk factor scoring questionnaire was adopted to systematically collect the clinical data for retrospective study. Results:The pregnancy risk factors in this study included: a history of bad pregnancy (18.40%) and age of pregnancy <18 or ≥35 (13.93%). The risk factors during pregnancy were as follows (in the turn of exposure)：premature rupture of membrane （30.60%），multiple gestation (≥2 fetuses)(29.35%), pregnancy-induced hypertension syndrome or epilepsy（23.88%）. With time going, the occurrence of such risk factors as history of bad pregnancy, maternal age of pregnancy<18 or ≥(35, and threatened abortion reduced, while the occurrence of multiple pregnancy(≥2 fetuses) increased. Regression analysis suggested that the occurrence of LBWI was related to history of bad pregnancy, age of pregnancy <18 or ≥35, premature rupture of membrane, pregnancyinduced hypertension syndrome or epilepsy, pregnancy induced diabetes and abnormal umbilical cord, and there was statistical difference among the groups (P<0.05). Conclusion:The occurrence of low birth weight infants is affected by various factors before pregnancy and perinatal period, and various complications can occur. The incidence of LBWI can be reduced by controlling high-risk factors as early as possible and strengthening health care during perinatal period. Related Articles | Metrics

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Study on the relationship between febrile seizures and NLR and MPR in children GUO Meiling，ZI Huifen 2021, 13 (1):  29.  Abstract ( 223 )   PDF (465KB) ( 28 )   Save Objective:To explore the correlation of neutrophil/lymphocyte ratio(NLR) and mean platelet volume/platelet count ratio(MPR) with febrile seizures. Methods:A total of 103 children with febrile seizures who were admitted to Baotou Central Hospital from October 2019 to December 2020 were selected as the observation group, and 109 children with acute upper respiratory tract infection who had fever without seizures were selected as the control group. The blood cells and electrolytes of the two groups were analyzed respectively, and the NLR and MPR values were calculated. Results:The NLR and MPR of the observation group were significantly higher than those of the control group, and the difference was statistically significant (P<0.05). The blood potassium and sodium of observation group were lower than those of the control group, and the difference was statistically significant (P<0.05); there was no statistically significant difference in blood chloride or calcium between the two groups(P>0.05). The ROC curves of NLR and MPR indicated that the best critical value of NLR was 3.79, the sensitivity was 80.6%, and the specificity was 56.0%; the best critical value of MPR was 0.032 55, the sensitivity was 72.8%, and the specificity was 53.2%. Conclusion:NLR and MPR are correlated with febrile seizures. At the same time, changes in serum electrolytes may also be an important cause of febrile seizures, among which blood sodium and potassium are lowered.  Related Articles | Metrics

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Analysis of susceptibility of bronchial asthma and its relationship with severity of bronchial asthma in children based on T2 locus polymorphism of ADAM33 gene LI Xiao,ZHANG Lei,TANG Yu,XU Chunna 2021, 13 (1):  33.  Abstract ( 451 )   PDF (366KB) ( 51 )   Save Objective:To investigate the T2 locus polymorphism of A Disintegrin and metalloproteinase 33 (ADAM33) gene in the analysis of the susceptibility and severity of bronchial asthma (BA) in children. Methods:Forty-seven child patients with BA admitted to the hospital from January 2017 to March 2019 were selected as the study group, and 47 healthy children who had physical examination during the same period were selected as the control group. There were 15 cases of severe asthma, 17 moderate and 15 mild cases in the study group. All patients were subjected to restriction fragment length polymorphism analysis (polymerase chain reaction). The Hardy-Weinberg equilibrium and allele frequency of T2 locus were compared between the two groups. The correlation between BA severity and T2 locus polymorphism was observed. Results:In regard to the gene frequency of the T2 locus, the subjects of the two groups had good group representation and all met the HardyWeinberg equilibrium. Among alleles of the T2 locus, the gene frequency of A of the study group was higher than that of the control group (P<0.05), and the high-risk factor for BA was the increase of the A allele. Among the T2 locus alleles, the AG genotype frequency of the children with severe or moderate asthma was higher than that of the children with mild asthma(P<0.05). The high-risk factor to distinguish the BA severity was the increase of AG allele. Conclusion:There is a correlation between BA and T2 locus polymorphism of ADAM33 gene. Once the A gene frequency increases, the BA risk will increase accordingly. In addition, the severity of BA can be determined according to the increase of AG allele. Related Articles | Metrics

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Effect of sodium valproate in the treatment of children with cerebral palsy complicated by subclinical epileptiform discharge ZHANG Duanxiu，CAI Huiqiang，HU Shuxiang 2021, 13 (1):  36.  Abstract ( 272 )   PDF (478KB) ( 70 )   Save Objective:To explore the clinical effect of sodium valproate in the treatment of cerebral palsy combined with subclinical epileptiform discharge. Methods:A total of 62 cases of cerebral palsy with subclinical epileptiform discharge were randomly divided into two groups，31 cases in each group. All the children received routine comprehensive rehabilitation treatment. On the basis of the above treatment，the observation group was given 20-40 mg/(kg·d) of sodium valproate oral solution，the blood concentration of which was controlled at 50-100 mg/L，and the course of treatment was 6 months. The control group did not use drugs. During the experimental period，each group was divided into two types according to whether there was clinical seizure or not. After six months of treatment, video EEG was examined to observe the control of epileptiform discharge. According to the results of EEG,the children with epileptiform discharge were divided into three categories: disappearance，improvement and no change. GMFM was used to observe the improvement of motor function. Results:During the follow-up period, one case in observation group and two cases in control group were lost. Six cases in observation group were complicated by clinical epileptic seizure, obviously fewer than the control group(13 cases), the difference being statistically significant(P<0.05). After treatment, the re-examination of EEG showed that the effective rate in observation group was 83.33%(25/30) for controlling subclinical epileptiform discharge in children with cerebral palsy, significantly higher than that in control group(34.48%, 10/29)（P<0.05）. Oral administration of sodium valproate in the observation group could improve the motion function more significantly, and there was statistical difference(P<0.05). Conclusion:Long term oral administration of valproate can effectively control or reduce the occurrence of epileptiform discharge and reduce the probability of clinical seizure in children with cerebral palsy who have subclinical epileptiform discharge. It can improve the motor function of children and improve the effect of rehabilitation treatment.  Related Articles | Metrics

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Clinical effect of coblation tonsillectomy on children with obstructive sleep apnea syndrome versus conventional dissection tonsillectomy WANG Junqi，MA Mingying，LU Eryong 2021, 13 (1):  39.  Abstract ( 385 )   PDF (503KB) ( 101 )   Save Objective:To investigate the influence of the coblation tonsillectomy and conventional dissection tonsillectomy on children with obstructive sleep apnea syndrome. Methods:A total of 146 children with obstructive sleep apnea syndrome were randomly divided into two groups: the observation group(n=76) and the control group(n=70). All patients underwent tonsillectomy: conventional dissection for control group and coblation for observation group. Children with adenoid hypertrophy in both groups were treated with Plasma ablation. The above operation was performed by the same operator. The time required and the amount of bleeding during operation were compared. Compare the postoperative sore throat, the time for the tunica to completely come off and the improvement in quality of life of the two groups before and after operation. Compare the sore throat and the time for the tunica to come off after the tonsillectomy with or without adenoid hypertrophy between the two groups. Results:The observation group had a shorter operative time than the control group, and the average amount of introoperative bleeding （4.3±2.8）mL was less than that of the control group（P<0.05）.The observation group had a milder sore throat at 1 day after operation than control group. At 4 days after operation, the children with tonsillectomy had a milder sore throat than those with adenoid hypertrophy, there was statistically significant difference between the two groups(P<0.05). The time for the tunica to completely off in observation group was significantly longer than that in the control，and there was statistical difference(P<0.05). There was no significant difference in the improvement in postoperative quality of life. Conclusion:Compared with conventional tonsillectomy, coblation tonsillectomy has shorter operation time, less intraoperative bleeding and milder symptoms of early postoperative pharynx discomfort, which has obvious advantages in dealing with complex tonsillectomy. Related Articles | Metrics

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Effect of low iodine concentration contrast medium on image quality of CTA in children with congenital heart disease CHEN Congcong, CUI Dejin, SUN Lifang, ZHENG Bin 2021, 13 (1):  43.  Abstract ( 205 )   PDF (483KB) ( 30 )   Save Objective:To investigate the effect of low iodine concentration contrast medium on the image quality of CTA in children with congenital heart disease. Methods:Totally 70 children with congenital heart disease diagnosed in our hospital from June 2019 to June 2020 were selected as the research subjects: 35 children receiving conventional iodine contrast medium(370 mgl/mL) were included in the control group, and 35 children receiving low iodine concentration iodine contrast medium(270 mgl/mL) were included in the low iodine group. Coronary CTA was performed in both groups, and the images were reconstructed by filtered back radiography (FBP). The CT values of cardiac cavity and large vessels, subjective score of CTA image clarity and contrast medium uniformity score were compared between the two groups. Results:There was no significant difference in the CT value of cardiac cavity and large vessels between the two groups (P>0.05); the image clarity of large vessels, cardiac structure and origin of coronary artery in the low iodine group was higher than that in the control group(P<0.05); the uniformity of contrast medium was compared, and there was no significant difference between right atrium and right ventricle(P>0.05). Conclusion:Low iodine concentration contrast medium is a good diagnostic method for congenital heart disease in children. It can obtain high-quality coronary CTA images, meet the needs of diagnosis, and reduce radiation dose. Related Articles | Metrics

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Effect of task-oriented training combined with biofeedback technology on balance ability and upper limb function of children with spastic cerebral palsy ZHANG Weidan，XING Lihua，LI Qiong 2021, 13 (1):  46.  Abstract ( 214 )   PDF (529KB) ( 60 )   Save Objective:To explore the effect of biofeedback technology combined with task-oriented training on upper limb function and balance of children with spastic cerebral palsy (SCP). Methods:123 children with SCP admitted to our hospital between May 2019 and August 2020 were selected and grouped according to the random number table method.Both groups were given routine rehabilitation training.61 cases in the control group were given biofeedback training on this basis.The 62 cases in the observation group added task-oriented training on the basis of the control group,and compared the degree of gastrocnemius spasm in the two groups:modified Ashworth scale (MAS);balance ability:Berg balance scale (BBS);standing and walking function:gross motor function Scale (GMFM);Upper Limb Function:Hand Function Assessment Scale (AHA);Developmental Level:Development Quotient (DQ),DQ is calculated by Gesell Scale. Results:After the intervention,the MAS score of the observation group was lower than that of the control group,and the scores of BBS,GMFM,AHA,and DQ were higher than those of the control group,with statistical significance (P<0.05). Conclusion:Task-oriented training combined with biofeedback technology intervention for children with SCP can effectively reduce the degree of spasticity,promote the recovery of upper and lower limb function and balance,and improve the level of intelligence. Related Articles | Metrics

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Plasma exchange in the treatment of one case of refractory nervous system disorders in children ZHAI Manman，GAO Ling，XU Hongdan，WANG Yuan 2021, 13 (1):  50.  Abstract ( 179 )   PDF (419KB) ( 37 )   Save Objective:To observe and analyze therapeutic plasma exchange(TPE) in the treatment of refractory nervous system immune disorders in children. Methods:One child with refractory nervous system immune disorders who was admitted to the hospital in 2019 was treated with TPE. The efficacy and safety were analyzed. Results:After the treatment, the clinical symptoms of the child were significantly improved. ECMO was withdrawn 10 days later, and ventilator was withdrawn 15 days later. After muscle strength treatment, the child recovered to normal and could walk and exercise. During the treatment, the rash complications occurred, which disappeared after the treatment of 5 mg dexamethasone and 20 mg finagen. Conclusion:The curative effect of TPE is good in the treatment of children with refractory nervous system immune disorders, which can effectively improve their clinical symptoms. Related Articles | Metrics

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Analysis of the occurrence and risk factors of drug poisoning in 106 children LIU Dong 2021, 13 (1):  52.  Abstract ( 279 )   PDF (417KB) ( 56 )   Save Objective：To investigate the occurrence of drug poisoning in children and analyze the causes. Methods：Totally 106 cases of drugpoisoned children admitted to our hospital from September 2016 to September 2019 were included as the research subjects. A cross-sectional study model was used to analyze common drugs and clinical manifestations in children with poisoning. During the same period, 160 cases of non-drug-poisoned children were taken as the control group. Both groups were given questionnaires to analyze the risk factors that affected children with poisoning. Results：(1) Among 106 children, 34.91% were 3-6 years old, 57.55% lived in rural areas, 25.47% used antibiotics, 37.74% were poisoned through the digestive tract, and 64.15% were poisoned by adults. (2) Among the clinical manifestations of children with poisoning, 77.36% of children had a rapid heart rate; 65.09% of children had abnormal respiratory symptoms; 63.21% of children had neurological symptoms; 48.11% of children had skin flushing; 41.51% of children had symptoms of the digestive system; 30.19% of children had abnormal urine; lack of company of relatives, lack of family medicine management, and parents not strictly administering drugs were the independent risk factors for drug poisoning in children, and a good education background and keeping breathing smoothly on visiting hospital for emergency treatment were all protective factors, and the differences were statistically significant(P<0.05). Conclusion：Drug poisoning in children often involves multiple systems. Being unaccompanied by family members, parents' low education level, lack of drug management, and lack of first aid knowledge are all risk factors for drug poisoning Related Articles | Metrics

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Analysis of the clinical distribution and drug resistance of carbapenemresistant Klebsiella pneumoniae in children LI Ke, ZHOU Juanjuan, REN Chong 2021, 13 (1):  55.  Abstract ( 328 )   PDF (513KB) ( 29 )   Save Objective:To investigate and analyze the clinical distribution and drug resistance of carbapenem-resistant Klebsiella pneumoniae(CRKP) in children. Methods:All kinds of submitted samples of children hospitalized in the hospital from December 2015 to December 2018 were collected. Isolation and culture of CRKP and bacterial identification were performed on the submitted samples. The K-B method and drug sensitivity card were used to test the sensitivity of the isolated CRKP strains. The distribution characteristics of CRKP infection in children were analyzed, and the resistance to commonly used antibacterial drugs was analyzed. Results:A total of 156 strains of CRKP were isolated, including 149 strains detected by Carba NP test, with a positive rate of 95.51%. The main specimens were sputum and urine specimens, accounting for 51.28% and 16.67%, respectively. The main departments from which CRKP strain specimens came included the Neonatology Department(29.49%), the Respiratory Department (25.64%) and the ICU (14.10%). Among the other 16 antibiotics commonly used in the clinic, the resistance rates of CRKP to cephalosporins, penicillins and quinolone antibiotics were higher than 90%. The resistance to aminoglycoside, tetracyclines and sulfonamides was relatively low. Conclusion:CRKP infection is widespread in children, especially in the Neonatology Department. In addition, the resistance of carbapenem-resistant Klebsiella pneumoniae is serious, and it has high resistance to most of the antibiotics. Therefore, it is necessary to choose antibiotics reasonably according to the results of drug sensitivity so as to effectively control infection.  Related Articles | Metrics

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Clinical significance of hearttype fatty acid binding protein and Z value of coronary artery in early diagnosis of Kawasaki disease CHEN Qiang, ZHAO Haiyan, ZI Huifen, HOU Yi, YANG Wen, SONG Tianyue 2021, 13 (1):  58.  Abstract ( 458 )   PDF (654KB) ( 70 )   Save Objective：To study the clinical significance of heart-ype fatty acid binding protein (h-ABP) and coronary artery Z value in early diagnosis of Kawasaki Disease in children. Methods：From October 2018 to August 2020, 50 children with Kawasaki disease were confirmed and treated in Baotou Central Hospital of Inner Mongolia Autonomous Region, who were included as the observation group, and 55 children with respiratory tract infection were included as the control group. The h-ABP and coronary artery Z value of children with Kawasaki disease in the acute and recovery period were collected, and the h-ABP and coronary artery Z value of children with respiratory tract infection on admission was collected, and they were analyzed statistically. Results：The h-ABP level in acute stage of observation group was higher than that of control group, there being statistical difference(P<0.05); there was no statistical difference in h-BP level in convalenscence stage between observation group and control group (P>0.05); the h-ABP level of observation group was significantly higher in acute stage than in convalescence stage(P<0.05). The Z value of left coronary artery(LCA) and left anterior descending branch(LAD) in acute stage of observation group was significantly higher than that of control group(P<0.05). There was no statistical difference between observation group and control group in the Z value of right coronary artery(RCA) in acute stage, the RCA- value in convalenscence stage, LCA- value or LAD- value(P>0.05). There was no relationship between h-ABP level and RCA, LCA or LAD(P>0.05). Linear regression analysis showed that RCA, LCA and LAD couldn't affect h-ABP level(P>0.05) Conclusion：（1）There is an increase of h-ABP in children with Kawasaki disease, which may provide a basis for the early diagnosis of Kawasaki disease or atypical Kawasaki disease. （2）The level of h-P in convalescence stage in children with Kawasaki disease was significantly lower than that in acute stage, which can be used to evaluate whether there is myocardial damage in children with Kawasaki disease as early as possible. （3）The dilation of coronary artery can occur in the early stage of Kawasaki disease, and is most likely to cause LCA and LAD dilation, which can provide some clinical basis for the early diagnosis of Kawasaki disease or atypical Kawasaki disease. （4）If the level of h-BP can be added into the diagnosis standard of Kawasaki disease and combined with the Z value of coronary artery, Kawasaki disease may be found and confirmed earlier, especially atypical Kawasaki disease. Related Articles | Metrics

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Closed reduction and modified lateral cross Kirschner wire internal fixation to treat 43 children with humeral supracondylar fractures XIA Hongtao，QU Chang，MA Junteng 2021, 13 (1):  63.  Abstract ( 144 )   PDF (424KB) ( 37 )   Save Objective：To explore the effect of closed reduction and modified lateral cross Kirschner wire internal fixation in the treatment of children with supracondylar fractures of the humerus and its influence on the function of the elbow joint. Methods：A total of 85 children with supracondylar fractures of the humerus who were admitted to our hospital from February 2018 to February 2019 were selected as the research subjects. According to the operation method, they were divided into 42 cases in the control group and 43 cases in the observation group. The control group received closed reduction and internal and lateral cross Kirschner wire internal fixation, and the observation group received closed reduction and modified lateral cross Kirschner wire internal fixation, and the therapeutic effects were compared. Results：The operation effect of the observation group was better than that of the control group. The time of operation, hospitalization and fracture healing was shorter than that of the control group. The degree of active movement of elbow joint and forearm was larger than that of the control group. The incidence of postoperative complications was lower than that of the control group. The difference in all the above aspects was statistically significant(P<0.05). Conclusion：Closed reduction and modified lateral cross Kirschner wire internal fixation can shorten the operation time in children with supracondylar fractures of the humerus, promote postoperative recovery, improve elbow joint function, and improve the surgical effect with fewer adverse reactions. Related Articles | Metrics

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Curative effect of mesalazine enteric-coated tablets combined with bifid triple viable capsules in the treatment of ulcerative colitis MA Yang 2021, 13 (1):  66.  Abstract ( 578 )   PDF (395KB) ( 54 )   Save Objective：To explore the curative effect of mesalazine enteric-coated tablets combined with bifid triple viable capsules in the treatment of children with ulcerative colitis. Methods：A total of 90 children with ulcerative colitis admitted to our hospital from May 2016 to October 2019 were selected as the research subjects, and they were randomly divided into the observation group(45 cases) and the control group(45 cases). The children in both groups were treated with mesalazine entericcoated tablets while the children in the observation group also took with bifid triple viable capsules. After 4 weeks of treatment, the treatment effects of the two groups were compared, the intestinal mucosal barrier function was evaluated, and the inflammatory factors were detected. Results：The therapeutic effect of the observation group was significantly higher than that of the control group (P<0.05). After treatment, the ratio of lactulose with mannitol urine excretion rate and endotoxin in the observation group were lower than those in the control group (P<0.05). After treatment, the hypersensitivity C-reactive protein and interleukin-6 in the observation group were significantly lower than those in the control group (P<0.05). Conclusion：Mesalazine enteric-coated tablets combined with bifid triple viable capsules can effectively improve the intestinal function and promote the rehabilitation of children with ulcerative colitis, and the combination of drugs is better than single drug. Related Articles | Metrics

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Distribution characteristics of intestinal flora in obese preschool children and the factors related to obesity ZHAO Dan 2021, 13 (1):  69.  Abstract ( 212 )   PDF (358KB) ( 67 )   Save Objective：To analyze the distribution characteristics of intestinal flora in obese preschool children, and study the related factors of obesity in preschool children. Methods：A total of 60 obese preschool children receiving physical examination in the hospital between July and December 2019 were selected as the observation group. Meanwhile, 120 healthy children were selected as the healthy control group by cluster sampling method. Intestinal floras of the two groups were detected and comparatively analyzed. Univariate analysis and multivariate regression analysis were performed to study the factors related to obesity in preschool children. Results：The level of Proteobacteria in intestines of the observation group was significantly higher than that in the healthy control group, and the level of Bifidobacterium was significantly lower than that in the healthy control group(P<0.05). Univariate analysis showed that birth weight, sleep time, eating speed, exercise amount, feeding pattern, obesity of parents, and dietary habits were factors related to obesity in preschool children(P<0.05). Multivariate analysis showed that eating speed, exercise amount, feeding pattern, obesity of parents and dietary habits were influencing factors of obesity in preschool children (P<0.05). Conclusion：Effective interventions for diets of preschool children should be carried out based on the risk factors to reduce the incidence of obesity in preschool children. Related Articles | Metrics

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Analysis of serum levels of early neonatal bone metabolism indexes SU Jun，FU Yangxi. 2021, 13 (1):  72.  Abstract ( 338 )   PDF (535KB) ( 33 )   Save Objective：To analyze the serum levels of bone metabolism indexes in early neonates. Methods：A total of 121 early neonates who were admitted to the neonatal department of our hospital from July 2018 to December 2019 were included. The concentration of serum indexes of bone metabolism was determined, including ALP, PINP, β-CTX, Ca, P, 25-(OH)D, PTH and CT, and the serum levels were analyzed. Results：(1) The serum PINP levels were all more than 1 200.00 μg/L, and 111 cases (91.74%) had lack or deficiency of vitamin D. (2) The level of PTH was higher in preterm infants than in term infants, while CT level was lower, and the difference was statistically significant(P<0.05). There was no difference in the other bone metabolism indexes between the preterm infants and term infants(P>0.05). (3) There was no correlation between serum levels of bone metabolism indexes and maternal age or gestational age. The β-CTX was negatively correlated with head circumference; Ca was positively correlated with body weight and head circumference; PTH was negatively correlated with body weight and body length; CT was positively correlated with body weight. Conclusion：(1)The incidence of lack of vitamin D or deficiency is high, and it is necessary to strengthen the regular supplementation of vitamin D in pregnant mothers. (2)The serum levels of PTH and CT in newborns are related to gestational age. The serum level of PTH in the preterm infants was higher than that in term infants, while the CT level was lower. (3)Serum levels of newborn bone metabolism indexes are related to body weight, head circumference, and length. Related Articles | Metrics

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Clinical study of Jiawei Qingxin Lianzi decoction in the treatment of nephrotic syndrome during hormone withdrawal period WANG Hai, WU Mingyue, ZHANG Yongzheng. 2021, 13 (1):  76.  Abstract ( 752 )   PDF (561KB) ( 85 )   Save Objective:To observe the effect of Jiawei Qingxin Lianzi decoction on nephrotic syndrome during hormone withdrawal. Methods:From March 2018 to March 2019, 70 children with simple nephrotic syndrome were treated the Second Outpatient Department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, and they were randomly divided into two groups. On the basis of conventional hormone therapy, 35 cases in the control group were treated with Huaiqihuang granules, and 35 cases in the experimental group were given Jiawei Qingxin Lianzi decoction, the course of treatment being 8 weeks. The TCM symptom scores, side effects and height growth were compared between the two groups before and after treatment, and the relapse after treatment was also compared. Results:There were 3 cases who were lost of follow-up in experimental group and 5 cases in the control group. After treatment, the TCM symptom score, recurrence rate and incidence of side effects in the experimental group were lower than those in the control group, and the difference was statistically significant(P<0.05); the total effective rate in experimental group was 90.6%(29/32), which was higher than that in control group(60.0%, 18/30)(P<0.05); the increase in height of the children in the experimental group was higher than that in the control group, and the difference was statistically significant(P<0.05). Conclusion:Jiawei Qingxin Lianzi decoction has a synergistic and detoxifying effect on hormone treatment for nephrotic syndrome, and reduces the recurrence rate and improves the prognosis of children. Related Articles | Metrics

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Investigation into the use of antibiotics in the treatment of 298 children with respiratory diseases WANG Guiling，GENG Yuzuo， WANG Yuanyuan， DUAN Changfeng，LI Jiangquan. 2021, 13 (1):  80.  Abstract ( 431 )   PDF (625KB) ( 125 )   Save Objective:To investigate the application of antibacterial medicines in pediatric respiratory diseases to search for effective ways of management and intervention. Methods:The medical records of 298 children with respiratory diseases treated in Suqian TCM Hospital from December 2017 to January 2019 were collected and analyzed. Results:Among the 298 cases, the utilization rate of antibiotics in children with acute upper respiratory tract infection was 63.2%, and that in children with tracheal bronchitis reached 83.9%,the difference being statistically significant(P<0.01).Among the 298 cases, the total utilization rate of antibacterial drugs was 85.2%, that of oral antibacterial drugs was 62.2%, and that of injection antibacterial drugs was 50.8%.The common antibiotics prescribed were cephalosporins (63.4%), penicillins (41.3%), macrolides (31.8%), and others (7.0%), etc. About 61.4% of patients were treated with one antibacterial drug alone, 30.8% with two combined drugs, 7.4% with three combined drugs and 0.3% with four combined drugs, respectively, and the difference was statistically significant (P<0.01). Conclusion:The use of antimicrobial agents in children's respiratory diseases in this region is not very reasonable, which is manifested in the deficiency in drug indication, route of administration, variety selection and combination of drugs. It is still very important to raise awareness of antimicrobial resistance, organize education and training, and strengthen the construction and supervision of primary health care. Related Articles | Metrics

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Investigation and analysis of high risk factors of cerebral palsy in children in Wuxi area LU Ying，LIU Yimei，ZHANG Na 2021, 13 (1):  84.  Abstract ( 1000 )   PDF (577KB) ( 65 )   Save Objective:To analyze the relevant risk factors of cerebral palsy in children in Wuxi area，and to provide evidence for preventing the incidence of cerebral palsy. Methods:A total of 50 children with cerebral palsy hospitalized in Pediatric Rehabilitation Center of Wuxi Children's Hospital from January 2017 to December 2019 were selected as observation group. Another 100 healthy children undergoing physical examination in our hospital in the same period were selected as control group. A 1∶2 matched case-control study was conducted. Complete the questionnaire by inquiring the parents of the children. The survey items included gender of children，maternal age，radiation contact，drug use during pregnancy，living in new houses or driving new cars，working，smoking history，drinking history， history of abortion，preventing miscarriage，taking folic acid，delivery methods，bad mood，pregnancy complications, regular prenatal examination，preterm birth，birth weight，neonatal asphyxia，hypoxic -ischemic encephalopathy，and pathological jaundice. All data were analyzed with univariate analysis and multivariate Logistic regression analysis. Results:Univariate analysis showed that maternal age, working，smoking history，history of abortion，bad mood，number of births，low weight at birth， neonatal asphyxia，hypoxic-ischemic encephalopathy and pathological jaundice were risk for cerebral palsy in children(P<0.05). The multivariate analysis showed that maternal age，smoking history，history of abortion，bad mood，number of births，premature delivery，low weight at birth，neonatal asphyxia and hypoxicischemic encephalopathy were the independent risk factors. Conclusion:The relevant risk factors of cerebral palsy in children are various. In order to provide scientific theoretical basis for reducing the incidence of cerebral palsy in children，preventive measures are taken and epidemiological investigation and statistics about common risk factors are carried out. Related Articles | Metrics

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Analysis of Allergen test results in 1 440 children with allergic rhinitis in Ordos Area of Inner Mongolia SA Rina，LI Xiaoan，WANG Yumeng，WANG Aiqiong，FU Qiang. 2021, 13 (1):  89.  Abstract ( 382 )   PDF (565KB) ( 17 )   Save Objective：To learn about the distribution of allergens in children with allergic rhinitis in Ordos Area, Inner Mongolia. Methods：Retrospectively analyze the results of allergen test in 1 440 children with allergic rhinitis aged 0 to 18 years who were treated in the Otolaryngology and Pediatric Department of our hospital from January 2017 to December 2019. Results：The top six allergens in different age groups were compared, and the differences in Artemisia, Quinoa/Antibranched Amaranth, Ambrosia artemisiifolia,Aspergillus candidum and Milk were statistically significant (P<0.05). The number of children with positive inhaled allergen, such as Artemisia, Quinoa/Antibranched Amaranth and Ambrosia artemisiifolia, and the positive rate significantly increased from July to September each year. Conclusion：Inhaled allergens such as Artemisia, Quinoa/Anti-branched Amaranth and Ambrosia artemisiifolia are the main allergens in children with allergic rhinitis in Ordos Area of Inner Mongolia. Ingestion allergens are the main allergens in children with allergic rhinitis less than 3 years old, and with age increasing，the positive rate of ingestive allergens gradually decreases, and the positive rate of inhaled allergens in children gradually increases.  Related Articles | Metrics