Table of Content

25 April 2020, Volume 12 Issue 2 Previous Issue    Next Issue

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Suggestions on prevention and treatment of novel coronavirus infection in children by traditional Chinese medicine 2020, 12 (2):  93-95.  doi: 10.3969/j.issn.1674-3865.2020.02.001 Abstract ( 282 )   PDF (407KB) ( 35 )   Save With the control of the epidemic, various regions have gradually lifted their closures, but clustered epidemic has occurred frequently. After the opening of kindergartens and schools, the chance of infection in children will be greatly increased. In order to avoid the epidemic rebound or its spreading again, suggestions on prevention and treatment of 2019 novel coronavirus infection in children by traditional Chinese medicine are put forward based on Diagnosis, treatment and prevention advice on 2019 novel coronavirus infection in children (first edition), the TCM treatment section of Experts' consensus on the diagnosis, treatment and prevention of 2019 novel coronavirus infection in children (second edition), and the TCM interpretation of experts' consensus on the diagnosis, treatment and prevention of 2019 novel coronavirus infection in children (first edition), with a view to provide guidance for the pediatric clinical treatment and the protection of children staying at home. Related Articles | Metrics

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Recommendations for clinical management of children with myocarditis during the epidemic period of COVID-19 2020, 12 (2):  96-101.  doi: 10.3969/j.issn.1674-3865.2020.02.002 Abstract ( 210 )   PDF (831KB) ( 57 )   Save The outbreak of COVID-19 in December 2019 has spread to all parts of China,  and the number of infected children has been increasing. Epidemiology shows that generally all people are susceptible to the virus. The patients with basic diseases, especially cardiovascular diseases, are at high risk of critical diseases. The children with myocarditis have the history of myocardial diseases, such as myocardial fibrosis, so when it is complicated with COVID-19, the diagnosis and treatment face great challenges. Based on the clinical characteristics of COVID-19 and the key points of management of myocarditis in children, we put forward the clinical management recommendations for COVID-19 in children with myocarditis. Related Articles | Metrics

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Analysis of clinical TCM features and tongue manifestations of suspected cases of novel coronavirus infection in Lingnan children 2020, 12 (2):  101-105.  doi: 10.3969/j.issn.1674-3865.2020.02.003 Abstract ( 396 )   PDF (591KB) ( 70 )   Save Objective To study the clinical TCM features and tongue manifestations of suspected cases of novel coronavirus infection in Lingnan children. Methods The data of 43 suspected cases of novel coronavirus infection in children from Guangzhou Women and Children's Medical Center were collected, and the clinical features, tongue manifestations and the relationship between tongue manifestations and the symptoms were analyzed. Results The main clinical features of the children were fever, cough, runny nose and poor appetite. The majority of fever was Zhuang fever (48.8%), and the majority of cough was with phlegm (60.5%). Most of the suspected cases were with red tongue (76.7%), and white greasy tongue coating was most common(53.5%), followed by thin white tongue coating (44.2%). There is only one case with thin yellow coating (2.3%). The total number of white blood cells and lymphocytes was in the normal range in 88.4% and 65.1% of the children, respectively, but 32.6% of the children had different degrees of lymphopenia. The chest X-ray examination results showed that the bilateral lung texture was thickened and blurred in 63.6% of the children, and only 27.3% of the children had pulmonary infection. There were 8 cases(about 18.6%) with positive results of novel coronavirus nucleic acid detection. The results of correlation analysis between symptoms and tongue manifestations showed that there was a strong correlation in the following pairs: red tongue-cough, fever-red tongue, red tongue-cough and fever, red tongue-white greasy tongue coating, cough-white greasy tongue coating, and feverwhite greasy tongue coating.Conclusion The clinical features of the suspected cases are basically the same with the confirmed cases. According to the tongue manifestations and symptoms, they are in line with the seasonal pathogenetic characteristics of children in Lingnan area. The main syndrome types are damp syndrome and heat syndrome, and there is a small part of cold syndrome. Related Articles | Metrics

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Effect of acupoint injection of rat nerve growth factor on intelligence development and motor function of children with cerebral palsy 2020, 12 (2):  106-109.  doi: 10.3969/j.issn.1674-3865.2020.02.004 Abstract ( 210 )   PDF (432KB) ( 45 )   Save Objective To investigate the effect of acupoint injection of rat nerve growth factor (NGF) on children with cerebral palsy Methods Totally 100 children with cerebral palsy admitted to our hospital from May 2017 to May 2019 were randomly divided into two groups,50 in each group. The control group was given routine rehabilitation treatment,and the observation group was given acupoint injection of rat nerve growth factor + routine rehabilitation treatment. The intelligence development,motor function and children′s language development of the two groups were compared and analyzed. Results There was no significant difference between the two groups in gross motor function classification system(GMFCS) scores,developmental quotient(DQ) or the scores of S-S assessment before and after treatment(P>0.05) After treatment,the GMFCS scores decreased,while DQ and S-S scores increased in both groups;GMFCS scores in observation group were lower than those in control group,while DQ,S-S understanding score and S-S expression scores were higher(P<0.05) Conclusion Acupoint injection of rat nerve growth factor can promote the intelligence development of children with cerebral palsy,and improve their motor function and language development. Related Articles | Metrics

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Intervention effect of Polygonum cuspidatum extract on myocardial injury in mice with Mycoplasma pneumoniae infection 2020, 12 (2):  109-112.  doi: 10.3969/j.issn.1674-3865.2020.02.005 Abstract ( 205 )   PDF (474KB) ( 51 )   Save Objective  To study the effect of Polygonum cuspidatum extract on myocardial injury in mice with Mycoplasma pneumoniae infection. Methods Totally 30 BALB/c mice were randomly divided into normal group, MP model group and Polygonum cuspidatum extract group, with 10 mice in each group. The normal group was nasally infused with normal saline, and the MP model group and Polygonum cuspidatum extract group were all nasally infected with mycoplasma bacteria solution for 3 consecutive days. Treatment started on the first day of infection and continued for 3 days. The expression level of creatine kinase isoenzyme(CK-MB), cardiac troponin(cTnI), myoglobin(Mb) and aspartate aminotransferase(AST) in serum of mice were detected by ELISA method. Results Compared with the normal group, the levels of all the myocardial injury markers in the MP model group were significantly increased(P<0.01); compared with the MP model group, in the Polygonum cuspidatum extract group CK-MB, cTnI, Mb and AST levels were significantly down-regulated(P<0.01). Conclusion Polygonum cuspidatum extract can decrease the levels of CK-MB, cTnI, Mb and AST, significantly improve myocardial damage in mice with Mycoplasma pneumoniae infection, and protect the heart. Related Articles | Metrics

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Combination of Baduanjin and behavioral group therapy as a treatment for children with ADHD: a preliminary study 2020, 12 (2):  113-118.  doi: 10.3969/j.issn.1674-3865.2020.02.006 Abstract ( 247 )   PDF (609KB) ( 46 )   Save Objective To investigate the feasibility of the combination of Baduanjin and behavioral group therapy as a treatment for children with ADHD. Methods We collected data from 24 children diagnosed with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition(DSM-5). Behavioral group therapy was applied according to the Incredible Years Dina Dinosaur Treatment Program; Baduanjin daily practice was required during the treatment. The Swanson, Nolan, and Pelham Questionnaire(SNAP-Ⅳ), Achenbach Child Behavior Checklist(CBCL), Strengths and Difficulties Questionnaire(SDQ), PiersHarris Children's Selfconcept Scale(PHCSS) and Scoring Evaluation of the TCM Syndromes were used to evaluate the outcome. We used paired T test or rank-sum test to compare the data before and after treatment. Results There are significant decrease in SNAP-Ⅳ hyperactivity-impulsivity symptom and oppositional defiant disorder symptom after treatment(P<0.01). The scores of TCM syndromes has significantly decreased after treatment(P=0.001). Conclusion The combined application of Baduanjin and behavioral group therapy is an effective treatment for children with ADHD. The mechanism of it needs to be further studied, and it has a promising potential in clinical practice. Related Articles | Metrics

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Progress in the diagnosis and treatment of children with protracted bacterial bronchitis 2020, 12 (2):  119-124.  doi: 10.3969/j.issn.1674-3865.2020.02.007 Abstract ( 256 )   PDF (615KB) ( 53 )   Save Chronic cough is a common symptom of respiratory diseases in children，protracted bacterial bronchitis (PBB) is the common cause of chronic cough in children worldwide.PBB refers to a persistent infection of the endobronchial membrane caused by bacteria，and is characterised by an antibiotic-responsive wet cough persisting for longer than 4 weeks.Bacterial culture of bronchoalveolar lavage fluid has shown Haemophilus influenza,Streptococcus pneumonia and Moraxella catarrhalis to be the main pathogens.The occurrence of PBB is related to bacterial biofilm formation in the airway,impaired mucociliary clearance,systemic immune disorder,and airway anomalies Currently,the mainstay of PBB treatment is a 2-week therapy with antibiotics,such as amoxicillin-clavulanate,to eradicate the infection and restore epithelial integrity.PBB is considered as forerunner of other chronic respiratory diseases like bronchiectasis and chronic suppurative pneumonia.Currently,PBB hasn′t been fully recognized by most pediatricians in China. This article reviews the protracted bacterial bronchitis in children concerning the etiology,pathogenesis,clinical manifestations,diagnostic criteria,and treatment. Related Articles | Metrics

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Research progress in central nervous system damage caused by Mycoplasma pneumoniae infection in children 2020, 12 (2):  124-127.  doi: 10.3969/j.issn.1674-3865.2020.02.008 Abstract ( 132 )   PDF (469KB) ( 66 )   Save Mycoplasma pneumoniae is one of common respiratory pathogens in children.It not only can cause respiratory manifestations,but also can cause extrapulmonary manifestations.The diseases affecting the nervous system,both the peripheral (PNS) and the central nervous system (CNS),are the most severe.In some cases,particularly when the CNS is involved,M.pneumoniae-related neuropathies can lead to death or persistent neurologic problems.The diagnostic specificity and sensitivity of Mycoplasma pneumoniae infection in the central nervous system is not high by serologic examination,and it was difficult to detect MP in CSF.As the pathogenesis of MP infection in central nervous system is still unclear,its treatment is still controversial in clinical practice Related Articles | Metrics

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Research progress of Chinese medicine treatment for short stature children 2020, 12 (2):  128-131.  doi: 10.3969/j.issn.1674-3865.2020.02.009 Abstract ( 281 )   PDF (543KB) ( 108 )   Save This paper mainly makes a retrospective analysis and summary of TCM literature related to dwarfism in the past 10 years,aiming to provide a theoretical basis for TCM diagnosis and treatment of dwarfism.The treatment for dwarfism in TCM includes oral administration of Chinese medicine,acupuncture,massage,acupoint application,etc The curative effect is good,the price is relatively low and there are fewer adverse reactions,so it is worthy of clinical promotion and further study. Related Articles | Metrics

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Clinical analysis and nursing of children with allergic purpura 2020, 12 (2):  131-134.  doi: 10.3969/j.issn.1674-3865.2020.02.010 Abstract ( 168 )   PDF (550KB) ( 55 )   Save HSP is one of the common autoimmune diseases in children. In recent years, the incidence of the disease has been increasing year by year, which may be related to the changes of children's constitution, diet, exercise and environment. There have been obvious pathogenesis and treatment progress in the prevention and treatment of HSP in TCM and western medicine. However, the treatment results and the control of the recurrence rate of HSP need further discussion. Studies have shown that the therapeutic effect and recurrence rate of allergic purpura are closely related to clinical care after illness. Therefore, this article, based on analyzing the etiology of the disease and summing up the pediatrician's experience in the routine treatment and clinical care of allergic purpura in the Affiliated Hospital of Chengdu University of Chinese Medicine, aims to reduce the recurrence of children with HSP and complications and shorten the course of disease, in order to provide clinical guidance for the diagnosis, treatment and recovery of children with HSP, and reduce the economic and psychological burden of children and their families. Related Articles | Metrics

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Factors affecting rehabilitation compliance of children with autism spectrum disorder 2020, 12 (2):  135-137.  doi: 10.3969/j.issn.1674-3865.2020.02.011 Abstract ( 129 )   PDF (303KB) ( 51 )   Save Objective By investigating the related factors affecting the rehabilitation compliance of children with autism spectrum disorder, this paper aims to provide a theoretical basis for the effective rehabilitation of children with autism spectrum disorder.Methods A total of 103 children diagnosed with autism spectrum disorder in Weifang Maternal and Child Health Care Hospital from Jan. 2017 to Jan. 2019 were included as the research subjects. The observation group (n=50) received institutional intervention combined with family intervention, and the control group (n=53) were not intervened due to various reasons. The parents of the children were surveyed by questionnaires, and the questions included parents' knowledge about autism spectrum disorder, family economy, educational level of parents, parents' occupation, parents' confidence in the results of longterm rehabilitation, and parents' belief in physicians. The factors affecting the rehabilitation compliance of children with autism spectrum disorder were investigated. Results Univariate analysis showed that the differences in the three factors were statistically significant (P<0.05), which were parents' lack of understanding of autism spectrum disorder, parents' lack of confidence in the effect of longterm rehabilitation training, and family economic difficulties. Logistic regression analysis showed that parents' lack of understanding of autism spectrum disorders, parents' lack of confidence in the effect of longterm rehabilitation training, and family economic difficulties were the main factors affecting rehabilitation compliance. Conclusion It is of great significance for improving comprehensive rehabilitation effect and the life quality of children with autism spectrum disorder to increase the parents' knowledge about autism spectrum disorder, enhance their confidence in rehabilitation and promote the support of the society for the family with autism spectrum disorder. Related Articles | Metrics

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Effect of Jianpi Xiaozhi decoction on gastric emptying time and pepsinogen in children with functional dyspepsia 2020, 12 (2):  138-141.  doi: 10.3969/j.issn.1674-3865.2020.02.012 Abstract ( 183 )   PDF (430KB) ( 47 )   Save Objective To investigate the therapeutic effect of Jianpi Xiaozhi decoction on children with functional dyspepsia and its effects on gastric emptying time and pepsinogen. Methods Totally 89 children with functional dyspepsia admitted to our hospital from April 2018 to April 2019 were enrolled in this study. They were randomly divided into two groups: 44 in control group and 45 in observation group. Mosapride citrate was given to the control group, and the observation group received Jianpi Xiaozhi decoction combined with mosapride citrate.The effects, gastric emptying time and pepsinogen levels were compared between the two groups. Results The total effective rate was 91.1%(41/45), higher than that of the control group(70.5%, 31/44),and the difference was statistically significant(P<0.05). After treatment, the TCM syndrome scores in both groups significantly decreased, and the observation group was lower than the observation group, the difference being statistically significant(P<0.05). After treatment, the gastric emptying time was significantly shortened in both groups, and the observation group was shorter than the control group(P<0.05); the pepsinogen level in both groups were significantly increased , and the level of pepsinogen Ⅰand pepsinogen Ⅱ was higher in observation group than in control group(P<0.05). Conclusion  Jianpi Xiaozhi decoction has significant effects on children with functional dyspepsia. It can promote gastric emptying and enhance pepsin secretion and activity through promoting spleen activity and digestion. The therapeutic effect is remarkable and it is worthy of clinical recommendation. Related Articles | Metrics

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Professor Ding Ying's experience in treating pediatric refractory nephrotic syndrome 2020, 12 (2):  141-144.  doi: 10.3969/j.issn.1674-3865.2020.02.013 Abstract ( 239 )   PDF (569KB) ( 73 )   Save The purpose of this paper is to introduce Professor Ding Ying's experience in the treatment of pediatric refractory nephrotic syndrome. Professor Ding Ying believes that deficiency in origin and excess in superficiality are the main pathogenesis of pediatric refractory nephrotic syndrome, and the accumulation of evil qi is the main factor that distinguishes refractory nephrotic syndrome from general nephrotic syndrome. Therefore, under the guidance of Zhang Zihe's theory of "removing pathogenic factors for the reinforcement of vital qi", we should pay attention to the elimination of evil qi on the basis of supporting healthy qi, in order to achieve the therapeutic effect of "treating disease without evil, and removing pathogenic factors for the reinforcement of vital qi"，and the clinical effect is quite significant. Related Articles | Metrics

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Analysis of clinical effects of auditory integration training on children with language retardation 2020, 12 (2):  145-148.  doi: 10.3969/j.issn.1674-3865.2020.02.014 Abstract ( 822 )   PDF (382KB) ( 38 )   Save Objective To explore the clinical effect of auditory integration training in the treatment of children with language retardation. Methods A total of 70 children with language retardation who were admitted to our hospital from October 2018 to March 2019 were selected as the research subjects, and they were divided into the control group and the observation group with 35 cases each according to the simple randomization method. The control group was given speechcognition function training, and the observation group was given auditory integration training based on the function training. After 6 months of continuous training, the treatment effect, language ability and development quotient of the two groups of children were compared. Results After the intervention, the total effective rate in the observation group was 91.43%(32/35), higher than that in the control group(71.43%, 25/35), and the difference was statistically significant(P<0.05).The scores in receptive language ability, descriptive language ability and communicative language ability in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05).The scores in language ability, response ability, motor ability and physical ability in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). Conclusion Auditory integration training assists the treatment of children with language retardation, which improves clinical efficacy, speech function and language development. Related Articles | Metrics

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Clinical observation of Ear Three Needles for hearing impairment in children with kidney essence deficiency using lifting-thrusting reinforcing method 2020, 12 (2):  148-150.  doi: 10.3969/j.issn.1674-3865.2020.02.015 Abstract ( 321 )   PDF (350KB) ( 21 )   Save Objective To evaluate the curative effect of the Ear Three Needles for hearing impairment in children with kidney essence deficiency using the lifting-thrusting reinforcing method. Methods A total of 44 children with hearing impairment with kidney essence deficiency were included and divided into an observation group and a control group by random number table method,22 in each group.All children were checked the auditory brainstem response before treatment.Children in the observation group were acupunctured at Tinggong（SI19）,Tinghui（GB2）,Ermen（TE21）in the affected side using the lifting-thrusting reinforcing method.Those in the control group were acupunctured at the same acupoints as the observation group using the needle retention method for 30 minutes.Both groups were treated for 2 courses,with 30 days for 1 course of treatment,treatment interval being 7 days.The auditory brainstem response was checked again after the 2 course of treatment in both groups,and the clinical efficacy was evaluated. Results The results showed that the total effective rate was 72.7% (16/22) in the observation group,which was higher than that in the control group(40.9%,9/22).There was statistical difference between the two groups (P<0.05). Conclusion The Ear Three Needles using the lifting-thrusting reinforcing method can effective reduce the severity of hearing impairment in children with kidney essence deficiency,and improve the clinical treatment effect Related Articles | Metrics

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Study on quality of life of children with epilepsy 2020, 12 (2):  151-153.  doi: 10.3969/j.issn.1674-3865.2020.02.016 Abstract ( 166 )   PDF (277KB) ( 47 )   Save Objective To study the quality of life of children with epilepsy and what factors affect it.Methods Totally 75 children with epilepsy treated in the Department of Neurology and Department of Pediatrics of the People′s Hospital of Zhengzhou from January 2016 to January 2018 were randomly selected as the experimental group，At the same time normal children undergoing physical examination in the People′s Hospital of Zhengzhou were included as the control group.Quality of Life in Childhood Epilepsy(QOLCE) was used to assess the quality of life of children in the two groups.Their parents′ age,family income and parents′ education were recorded.At the same time,the age of onset,type of seizure,course of disease,type of medication and frequency of seizure in the recent half year were recorded.The difference in quality of life between the experimental group and the control group was compared,and the correlation between these factors and children′s quality of life was analyzed.Results The QOLCE score of the experimental group was lower than that of control group(P<0.05).There was no statistical difference between the parents of the two groups in age,educational background or family income(P>0.05).The QOLCE score of epileptic children had no significant correlation with their parents′ educational background,age of onset or family income,but was significantly negatively correlated with the frequency of seizures,the type of antiepileptic drugs taken and the course of epilepsy,and was correlated with the type of seizures.Conclusion In order to improve the quality of life of children with epilepsy,we need to reduce the types of antiepileptic drugs clinically used,reduce the frequency of seizures,control seizures,and enhance the understanding of epilepsy in the children with epilepsy and their parents. Related Articles | Metrics

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Clinical observation on the effect of scrapping along meridians combined with dialectical nursing on children with common cold with wind-heat syndrome 2020, 12 (2):  154-156.  doi: 10.3969/j.issn.1674-3865.2020.02.017 Abstract ( 160 )   PDF (360KB) ( 44 )   Save Objective To analyze the effect of scrapping along meridians combined with dialectical nursing on common cold with wind-heat syndrome in children. Methods From January 2018 to May 2018,80 cases of children with common cold with wind-heat syndrome were treated in our hospital.They were included as research subjects and divided randomly into two groups:the observation group（40）and control group（40）.The two groups of children received treatment of relieving heat and other symptomatic treatment and routine nursing.On this basis,40 cases of children in the observation group were treated with scrapping along meridians and dialectical nursing.The antipyretic effect and comprehensive treatment effect of two groups of children were compared and analyzed. Results After the scraping and nursing,the body temperature of the observation group was significantly lower than that of the control group(P<0.05)The total clinical effective rate of comprehensive treatment in observation group was 95.0%(38/40),significantly higher than that of the control group(77.5%,31/40)(P<0.05). Conclusion Scraping along meridians combined with dialectical nursing can significantly improve the clinical efficacy and promote the recovery. Related Articles | Metrics

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Scalp acupuncture combined with comprehensive rehabilitation for 2 cases of children with alternating hemiplegia 2020, 12 (2):  157-160.  doi: 10.3969/j.issn.1674-3865.2020.02.018 Abstract ( 157 )   PDF (638KB) ( 58 )   Save Objective To observe the effect of scalp acupuncture combined with comprehensive rehabilitation therapy on children with alternating hemiplegia. Methods Two cases of children with alternating hemiplegia were analyzed after gene detection,and were given scalp acupuncture and comprehensive rehabilitation treatment.Results The intelligence and motor function of two children with alternating hemiplegia were improved after treatment. Conclusion The earlier the onset of alternant hemiplegia,the more serious the condition.The combination of scalp acupuncture and rehabilitation therapy can improve the symptoms of children to a certain extent,and the effect on motor function is obviously better than the effect on intelligence. Related Articles | Metrics

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Changes and significance of serum cytokines in children with Kawasaki disease complicated with mycoplasma infection 2020, 12 (2):  160-163.  doi: 10.3969/j.issn.1674-3865.2020.02.019 Abstract ( 92 )   PDF (384KB) ( 56 )   Save Objective To study the changes and significance of serum cytokines in children with Kawasaki disease complicated with mycoplasma infection.Methods Totally 72 children with Kawasaki disease admitted to Pediatric Department of Cangzhou Central Hospital from January 2017 to December 2018 were selected as the study subjectsAccording to whether they were complicated with mycoplasma infection，the children were divided into mycoplasma infection group(n=18) and non-mycoplasma infection group(n=54)Serum MP-IgM,IL-6,IL-8,IL-10 and TNF-α were detected by ELISA. Results Before treatment,serum levels of IL-6,IL-8,IL-10 and TNF-α of mycoplasma infection group were obviously higher than those of nonmycoplasma infection group(P<0.05);after treatment,serum levels of IL-6,IL-8,IL-10 and TNF-α of two groups were significantly lower than those before(P<0.05),but the above indexes between the two groups had no statistically significant differences(P>0.05). Conclusion Levels of serum IL-6,IL-8,IL-10 and TNF-α are significantly increased in children with Kawasaki disease complicated with mycoplasma infection,and the detection of the above indicators are conducive to early detection of mycoplasma infection,which is worthy of clinical reference. Related Articles | Metrics

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Effect of montelukast sodium combined with interferon α-2b on serum inflammatory factor levels and rehabilitation process in children with respiratory syncytial virus-infected bronchiolitis 2020, 12 (2):  164-167.  doi: 10.3969/j.issn.1674-3865.2020.02.020 Abstract ( 156 )   PDF (414KB) ( 39 )   Save Objective To investigate the effect of montelukast sodium combined with interferon α-2b on serum interleukin-6 (IL-6), cysteine leukotriene (CysLTs), and eosinophils cationic protein(ECP), pulmonary surfactant protein D (SP-D) levels and rehabilitation process in children with respiratory syncytial virus-infected bronchiolitis. Methods A total of 128 children with RSV-infected bronchiolitis treated in our hospital from February 2018 to February 2019 were selected as the research subjects and randomly divided into a control group and an observation group of 64 cases each. The control group was given oxygen inhalation and antipyretic and sedative treatment, cough and phlegm relieving therapy, and intramuscular injection of recombinant human interferon α-2b. The observation group was treated with montelukast sodium, 4 mg orally every night before sleep in addition to the treatment for control group. Changes in serum IL-6, CysLTs, ECP and SP-D levels, and relief of clinical symptoms were compared between the two groups of children before and after treatment. Results Before treatment, there was no statistical difference in serum IL-6, CysLTs, ECP, or SP-D levels between the two groups of children(P>0.05). After treatment, serum IL-6, CysLTs, ECP, and SP-D levels in the two groups were lower than before treatment, and the observation group was significantly lower than the control group, the difference being statistically significant(P<0.05). The relief time of cough, wheezing and lung moist rales, the oxygen treatment time and the hospitalization time in the observation group were significantly lower than those in the control group, and the differences were statistically significant(P<0.05). The total effective rate in the observation group was 96.9%(62/64), which was higher than the control group(79.7%,51/64), and the difference was statistically significant(P<0.05). Conclusion Montelukast sodium combined with interferon alpha-2b has a synergistic anti-inflammatory effect on bronchiolitis caused by respiratory syncytial virus infection in children, which can effectively improve the level of inflammatory factors, shorten the rehabilitation process, and improve clinical efficacy. Related Articles | Metrics

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Clinical observation of Bawei Baizhu decoction combined with Sanxiang powder for external application in the treatment of infantile diarrhea of spleen deficiency 2020, 12 (2):  167-169.  doi: 10.3969/j.issn.1674-3865.2020.02.021 Abstract ( 330 )   PDF (352KB) ( 22 )   Save Objective To observe the clinical effect of Bawei Baizhu decoction combined with Sanxiang powder for external application in the treatment of children with diarrhea of spleen deficiency. Methods Totally 150 children with diarrhea of spleen deficiency treated in Yancheng TCM Hospital from Jan. 2018 to Jan. 2019 were chosen and divided into two groups by random and parallel control method: 90 in the observation group and 60 in the control group. The observation group was given Bawei Baizhu decoction for taking orally and Sanxiang powder for external application to the abdomen. The control group took Smectite suspension and Bifidobacterium quadruple tablet orally. The treatment lasted for 7 days as a course. After one course of treatment, the clinical effect in the two groups was assessed, and the time for diarrhea to stop in cured cases and the average frequency of diarrhea each day were observed. Results The clinical total effective rate was 76.7% (69/90) in the observation group, which was significantly higher than that in the control group (55.0%, 33/60), and there was statistical difference (P<0.05). The time for diarrhea to stop in cured cases and the average frequency of bowel movement each day were lower in the observation group than in the control group (P<0.05). Conclusion Bawei Baizhu decoction combined with Sanxiang powder for external application has good effect in the treatment of children with diarrhea of spleen deficiency, and it is better than western medicine. Related Articles | Metrics

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Analysis of pathogen composition and imaging characteristics of 120 children with lobar pneumonia infected in community 2020, 12 (2):  170-172.  doi: 10.3969/j.issn.1674-3865.2020.02.022 Abstract ( 158 )   PDF (301KB) ( 59 )   Save Objective To analyze the clinical characteristics and etiological changes of children with lobar pneumonia infected in communities. Methods A total of 120 children with lobar pneumonia admitted to Dongyang Maternal and Child Health Care Hospital from January 1,2019 to June 30,2019 were selected as the research subjects,and the clinical and etiological characteristics of the 120 patients with lobar pneumonia were analyzed retrospectively. Results The high incidence age was 3-6 years old.There was Mycoplasma pneumoniae infection in 73 cases(60.8%) and virus infection in 10 cases(8.3%)，and sputum culture was positive in 9 cases(7.5%);45.8%(55/120) of the children had their right lung involved,more than 36.7%(44/120) of the left lung,and the difference was statistically significant(P<0.05).After systematic treatment,the prognosis of most children was good. Conclusion The prevalence rate of Mycoplasma pneumoniae infection is high among hospitalized children with lobar pneumonia in our hospital.The high incidence age is 3-6 years old,and the prognosis is good after treatment. Related Articles | Metrics

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Preoperative interest inducement for reducing stress reaction of preschool and school-age children during peri-anesthesia period 2020, 12 (2):  172-175.  doi: 10.3969/j.issn.1674-3865.2020.02.023 Abstract ( 139 )   PDF (384KB) ( 52 )   Save Objective To explore the effect of preoperative interest induction to reduce the stress reaction of pre-school and school-age children during peri-anesthesia period. Methods A total of 106 children undergoing elective surgery in our hospital from February 1, 2017 to January 31, 2019 were included in the study, and they were randomly divided into observation group and control group, 53 cases each. The control group received routine nursing, and the observation group received combined preoperative interest induction. (1) Observe the degree of anesthesia induction coordination and anxiety self-rating scale(SAS) score; (2) observe heart rate and blood pressure in different periods;(3) observe anesthesia induction cooperation score(ICC) and modified Yale preoperative anxiety scoring(mYPAS) Score; (4) compare plasma cortisol, norepinephrine and epinephrine content in different periods. Results The degree of anesthesia induction coordination was higher in the observation group than in the control group, while the SAS score was lower, the difference being statistical (P<0.05). Before induction, there was no statistical difference in heart rate or blood pressure between the two groups (P>0.05). After induction, the heart rate and blood pressure during operation were lower in the observation group than in the control group (P<0.05). Before induction, there was no statistical difference in ICC or mYPAS score between the two groups (P>0.05). After induction, the ICC and mYPAS score were lower in the observation than in the control group (P<0.05). At 10min before induction, there was no statistical difference in plasma cortisol, norepinephrine or epinephrine between the two groups (P>0.05). At 5min after induction and during the operation, the level of plasma cortisol, norepinephrine and epinephrine was lower in the observation than in the control group (P<0.05). Conclusion Preoperative interest induction has a good effect on improving the psychological anxiety and anesthesia induction coordination of children. It can improve the psychological anxiety of children, improve the anesthesia induction coordination of children, and reduce the influence on heart rate, blood pressure, cortisol, epinephrine and norepinephrine. It decreases ICC and mYPAS scores, improves the stress status of children, and has high application value. Related Articles | Metrics

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Analysis of the clinical features and etiology monitoring results of 360 children with acute infectious diarrhea 2020, 12 (2):  176-180.  doi: 10.3969/j.issn.1674-3865.2020.02.024 Abstract ( 215 )   PDF (486KB) ( 26 )   Save Objective To analyze the clinical features and etiology features of children with acute infectious diarrhea, and to provide basis for the clinical treatment and prevention strategy of the disease. Methods The clinical data (demographic data, related living habits, disease data records, etc.) of 360 children with acute infectious diarrhea who were diagnosed and treated in pediatric department of our hospital from January 2017 to December 2018 were retrospectively collected. Fecal specimens were collected for pathogen detection. The main detection contents included 8 kinds of common bacteria and 6 kinds of viruses causing diarrhea in children. Summary and analysis were performed. Results There was no significant difference in age distribution among children with different genders(P>0.05). The onset age was concentrated within 5 years(89.17%). The diarrhea frequency of 3 to 5 times/d was the most common, complicated with fever, nausea, vomiting and abdominal pain. The proportion of people living in rural areas was higher than that in urban areas. The proportion of people with habits such as washing hands before meals, washing hands after using bathroom, no drinking of raw water and regular cutting of nails was less than 50%. Among the 360 fecal specimens, the total detection rate for common pathogens was 49.17%(177/360), including detection rate for pathogenic bacteria (15.56%,56/360) and detection rate for viral nucleic acid(33.61%,121/360). There was no significant difference in detection rate for pathogens between 2017 and 2018(P>0.05). The pathogens that were detected out were mainly Salmonella and enterodiarrheal Escherichia coli, and the viruses were mainly rotavirus and norovirus. There was no difference in the detection rate of common bacteria or viruses between 2017 and 2018(P>0.05). The proportion of acute bacterial diarrhea in autumn and summer was significantly higher than that in spring and winter(P<0.05), but the proportion of pathogenic bacteria in different seasons was not statistically different(P>0.05); the proportion of acute viral diarrhea in autumn and winter was significantly higher than that in spring and summer(P<0.05), and the proportion of rotavirus in winter was significantly higher than that in other seasons, and norovirus in autumn was significantly higher than that in other seasons(P<0.05). Conclusion From 2017 to 2018, the children with acute infectious diarrhea in the hospital are characterized by low age, poor self or family health, frequent onset in autumn and winter, bacterial and viral infections. The viruses are mainly rotavirus and norovirus. The pathogens are mainly Salmonella and entero-diarrheal Escherichia coli. Accordingly, the relevant departments should take corresponding measures to control incidence of acute infectious diarrhea in children. Related Articles | Metrics

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Analysis of influencing factors and clinical characteristics of intrauterine infection in preterm infants 2020, 12 (2):  180-182.  doi: 10.3969/j.issn.1674-3865.2020.02.025 Abstract ( 193 )   PDF (323KB) ( 62 )   Save Objective To study the influencing factors of intrauterine infection and analyze the clinical features of intrauterine infection in premature infants caused by placenta previa and premature rupture of membranes. Methods A retrospective analysis was made in 262 cases of premature infants with intrauterine infection treated in neonatal wards from January 2017 to January 2019. The general data such as gender, gestational age, birth weight, and asphyxia were recorded, and the perinatal factors related to preterm birth were recorded. The clinical characteristics of infection caused by placenta previa were compared with those caused by premature rupture of membranes. Results There are many factors leading to intrauterine infection in premature infants, and the top two most important perinatal factors were premature rupture of membranes and placenta previa (accounting for 51.2%), and the premature infants with intrauterine infection due to premature rupture of membranes mainly presented symptoms of non-specific infection, accounting for 52.4%. A small part of the infants had pneumonia related to intrauterine infection, and the ratio of infants needing ventilator support was very low (2.4%); however, pulmonary infection was the main infection in the premature infants with intrauterine infection due to placenta previa (62.0%), and the ratio of infants needing mechanical ventilation was significantly increased, nearly one-third of them(32.0%), the difference being statistically significant (P=0.033). Conclusion Premature infants born with placenta previa need to be specially alert to intrauterine infectious pneumonia and need active respiratory support. Related Articles | Metrics

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A survey on rationality of medication of common drugs in families of Shenyang urban area 2020, 12 (2):  183-185.  doi: 10.3969/j.issn.1674-3865.2020.02.026 Abstract ( 110 )   PDF (212KB) ( 38 )   Save This paper is aimed to achieve the effect of safe medication in children, guide the caregivers in the safe and effective medication for children, and improve parents' understanding in safe medication. A questionnaire survey is conducted in the parents in Shenyang urban area. The questions include the age and occupation of the caregivers and some other related family information. In addition, some special questions related to the medication for children common diseases in children are also involved. For the parents with different occupations, the medication habits and some common knowledge about drugs of the parents are presented here. Related Articles | Metrics