Table of Content

25 June 2016, Volume 8 Issue 3 Previous Issue    Next Issue

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Nutrition and puberty onset GUO Sheng，LI Pin 2016, 8 (3):  249-252.  doi: 10.3969/j.issn.1674-3865.2016.03.001 Abstract ( 369 )   PDF (481KB) ( 136 )   Save Puberty is an essential stage of physical and sexual development in life. Nutrition is one of the most important factors affecting pubertal development onset and maintenance. Nutritional status during fetal, infancy, childhood and prepubertal period has a significant effect on puberty development and maintenance. Children with early nutritional deficiency not only are likely to suffer from sexual precocity but also show an increase in their risk of developing non-infectious diseases in later life. The low-birth-weight infants who have achieved growth catch-up in infancy and childhood period are at a higher risk of developing premature pubarche, polycystic ovary and metabolic syndrome. In addition, nutritional structure and diet quality are also important factors affecting sexual development in children and adolescents. Some dieting problems during adolescence, such as nervous anorexia and bulimia nervosa, may have bad effect on the normal sexual development. On the basis of the latest literature reports, this paper makes a brief review on the problems related to nutrition and pubertal development. Related Articles | Metrics

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Research progress of regulatory effects of RFRP-3/GPR147 signaling pathway on mammalian reproductive system HAN Xinghui，YU Jian 2016, 8 (3):  253-256.  doi: 10.3969/j.issn.1674-3865.2016.03.002 Abstract ( 527 )   PDF (486KB) ( 145 )   Save The function of mammalian reproductive system，a complex biological process involving multiple regulators, depends on the regulation of hypothalamic-pituitary-gonad axis. At present, RFRP-3 is the only one inhibitor of HPG axis known at the hypothalamic level in mammals. In recent years, a large number of studies have found that RFRP-3 can inhibit GnRH and LH release in mammals by combining into the G protein coupled receptor 147(GPR147) and affect the function of reproductive system. In this review, the authors summarize the significant research advances in RFRP/GPR147 signaling pathway in mammalian species in the recent ten years. In addition, the regulatory mechanism of RFRP-3 in HPG axis and role of RFRP-3 in modulating mammalian reproductive system are systematically elaborated. Related Articles | Metrics

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Expression of ephrinB2 and EphB4 in a neonatal rat model of periventricular white matter damage resulting from hypoxia-ischemia FANG Guiwei,ZHANG Lihua,XU Hongwei,SUN Ying 2016, 8 (3):  257-260.  doi: 10.3969/j.issn.1674-3865.2016.03.003 Abstract ( 392 )   PDF (466KB) ( 118 )   Save Objective: To evaluate microvessel density (MVD) and the expression of ephrinB2 and its receptor EphB4 in a hypoxia-ischemia induced PWMD rat model. Methods: Postnatal day 3 Wister rats(n=60) were randomly divided into hypoxia ischemia group(group HI),sham operation group(control group),with 30 rats in each group.The HI group underwent permanent ligation of the right common carotid artery then they were exposed to hypoxia (94% N2+6% O2) for 4 hours.For the control group rats,the same surgery was performed except for ligation and exposure to hypoxia.MVD and levels of ephrinB2 and EphB4 were determined at postnatal day 7. Results: Compared with control group,MVD,ephrinB2 and EphB4 levels were higher in the brains of hypoxic-ischemic rats.Similar percentages of vessels expressed ephrinB2 and EphB4 in control group,but expression of ephrinB2 was greater in brains injured by hypoxia-ischemia. Conclusion: Following hypoxic-ischemic injury to the rat brain,there were angiogenesis and more arterioles than venules are acquired. Related Articles | Metrics

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Effect of Chaishao Pingxian(epilepsy-relieving) decoction on brain GABA content of young rats with epilepsy WEI Chong,ZHANG Baoqing 2016, 8 (3):  261-264.  doi: 10.3969/j.issn.1674-3865.2016.03.004 Abstract ( 373 )   PDF (530KB) ( 100 )   Save Objective: To study the effect of Chaishao Pingxian decoction on brain GABA content of young rats with epilepsy and to investigate its mechanism. Methods: The rats were randomly divided into 7 groups,by number,namely,low-(A),moderate(B) and high-dose(C) group,western medicine group(D),Chinese and western medicine group(E),model group(F) and normal control group(G),with 10 rats in each group.PTZ was injected into SD rats to establish epilepsy model and the behavior was observed.Chaishao Pingxian decoction was given as intervention treatment and after 24 days ELISA was used to determine GABA content in brain tissues. Results: There was statistical difference on convulsion grade between 24d after treatment and 1d before treatment in group E,but no difference in the other groups.Compared with group F,GABA content was higher in group A,B,C,D and E,and difference was statistical(P<0.01).When comparing GABA content of group G with that of the other six groups,there was statistical difference(P<0.01). Conclusion: Chaishao Pingxian decoction has therapeutic effect on the epilepsy grade and the decrease of GABA content in brain tissues in tats with epilepsy. Related Articles | Metrics

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Observation on the clinical curative effect of auricular point sticking in adjuvant treatment of infantile asthma(phlegmy heat warm lung) at acute stage ZHANG Xiaojin，ZHAO Qiong，LUO Yating，QIAN Ming 2016, 8 (3):  265-268.  doi: 10.3969/j.issn.1674-3865.2016.03.005 Abstract ( 464 )   PDF (507KB) ( 97 )   Save Objective:To study the effect of auricular point sticking in adjuvant treatment of infantile asthma(phlegmy heat warm lung) at acute stage,and to provide effective treatment programs for clinical control of asthma. Methods:There were 60 children meeting the diagnosis standard，who came from the Pediatric Outpatient Department of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January 2014 to May 2015,and they were randomly divided into two groups：the treatment group and the control group,each with 30 children.The treatment group was treated by Chinese medicine(Dingchuan decoction) and auricular point sticking therapy.The control group was treated only by Chinese medicine.After 7 days of treatment,the symptoms and signs scores before and after the treatments and clinical efficacy were analyzed. Results:The total effective rate of the treatment group was 96.7%(29/30)，and compared to 93.3% of the control group(28/30),there were no significant statistical differences(P>0.05).In the improvement of cough and expectoration，there were no statistical differences(P>0.05) between the two groups.However，in the improvement of wheezing,pulmonary wheezing rale and limitation of motion，the treatment group was better with statistical significance(P<0.05).After treatment,the signs，including tongue,pulse,pharyngeal red,dry mouth,red face,yellow urine,constipation and yellow sputum，in two groups were improved(P<0.05),and the difference was statistically significant，but there was no statistical difference(P>0.05) between the two groups. Conclusion:During an asthma attack,auricular point sticking therapy combined with traditional Chinese medicine,can relieve wheezing,pulmonary wheezing rale and the limited mobility,achieving the goal of treatment.Auricular point sticking therapy is simple and reliable,which is worthy of promoting. Related Articles | Metrics

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Value of fractional exhaled nitric oxide in the diagnosis and treatment of children with cough variant asthma NIU Wenze，DU Xufang，MENG Liuming，HUANG Yaping，YUAN Xihua，YAN Mengyao，HUANG Weiliang，ZHOU Jiongying 2016, 8 (3):  269-272.  doi: 10.3969/j.issn.1674-3865.2016.03.006 Abstract ( 426 )   PDF (453KB) ( 90 )   Save Objective: To examine the levels of fractional exhaled nitric oxide(FeNO) in children with cough variant asthma(CVA) and explore its value in the diagnosis and treatment of children with CVA. Methods: From June 2014 to June 2015,174 cases of children with chronic cough identified in the Second People′s Hospital of Changshu were involved in the study.There were 106 cases of CVA and 68 cases of non-CVA.The levels of FeNO and total serum IgE were detected in two groups.Evaluate the diagnostic value of FeNO to CVA by drawing ROC curve,and analyze the best cutoff value of CVA.Follow-up and FeNO test were made after treatment of 4 weeks. Results: The levels of FeNO for CVA group was (28.16±10.89) μg/L,significantly higher than the non-CVA group (17.91±5.48) μg/L,the difference being statistically significant(P<0.01).The area under the ROC curve was 0.775,and the optimal FeNO cutoff value was 20.5 μg/L with a sensitivity of 74.5% and a specificity of 84.5%.FeNO was positively related to total serum IgE in CVA children(r=0.285,P=0.003).After four weeks of treatment,the value of FeNO［(14.57±5.23)μg/L］ after treatment was significantly lower than that before treatment［(28.16±10.89)μg/L］,the difference being statistically significant(P<0.01). Conclusion: FeNO test has a high sensitivity and specificity in the diagnosis of CVA.Children with CVA have a close connection with allergic factors.Furthermore,if the FeNO level of CVA children has increased,the therapy of ICS will be effected. Related Articles | Metrics

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Observation on blood glucose，insulin, cortisol and complication in infants of gestational diabetic mothers and healthy macrosomia DENG Jinyou，LIAN Yunsi，LIN Tao 2016, 8 (3):  272-274.  doi: 10.3969/j.issn.1674-3865.2016.03.007 Abstract ( 319 )   PDF (335KB) ( 86 )   Save Objective: To observe the characteristics of blood glucose，insulin, cortisol and complication in neonates of mothers with gestational diabetes mellitus(GDM) and healthy macrosomia. Methods: The 38 cases of neonates of GDM mothers(group A), 34 cases of healthy macrosomia of mothers without GDM(group B) and 35 healthy neonates of mothers without GDM(group C) born in our hospital from January 2014 to June 2015 were included in the study. The level of blood glucose，insulin and cortisol were measured in the three groups, and complication were also recorded in the 3 groups, including asphyxia, hypoglycemia, hyperbilirubinemia, hypocalcemia and polycythemia. Results: Compared with group C，the level of blood glucose in group A and group B was apparently lower(P＜0.05), while the level of insulin and cortisol in group A and group B was apparently higher, the difference was of statistical significance. There was no difference in blood glucose, insulin or cortisol between group A and group B(P>0.05)| The incidence of hypoglycemia in group A was significantly higher than that in group C and the difference was statistical(P<0.017). Conclusion: The abnormal rate of blood glucose，insulin and cortisol in the infants of gestational diabetic mothers and healthy macrosomia is high, and GDM neonates should be monitored for hypoglycemia. Related Articles | Metrics

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Immunotherapies for Mycoplasma pneumoniae pneumonia in pediatrics CHEN Qiang，ZI Huifen 2016, 8 (3):  275-277.  doi: 10.3969/j.issn.1674-3865.2016.03.008 Abstract ( 277 )   PDF (398KB) ( 86 )   Save The damage of the Mycoplasma pneumoniae to children includes direct pathogens damage and immune damage after infection.The immunity damage can promote the occurrence of severe mycoplasma infection,so the immune treatment for children with mycoplasma pneumonia is particularly important,which includes adrenaline corticosteroids,gamma globulin,immune modulators,traditional Chinese medicine,antibiotics,vitamin D,specific vaccine therapy,etc. Related Articles | Metrics

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Sustained and controlled release preparation and development of pediatric preparation type WANG Feng， SUN Qian，SONG Guangyi 2016, 8 (3):  277-279.  doi: 10.3969/j.issn.1674-3865.2016.03.009 Abstract ( 539 )   PDF (440KB) ( 175 )   Save Sustained and controlled release preparation is a hot spot in the research and development of new drugs. It has the characteristics of less dosage, longer action time and fewer adverse reactions. In this paper, through the analysis and summary of published literatures, the characteristics of sustained and controlled release preparation and the problems related to higher rate of clinical adverse reactions were analyzed in order to provide reference for the development of sustained and controlled release preparation in pediatrics. Related Articles | Metrics

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Clinical observation on the effect of nasal allergy soup combined with meridian massage for children with allergic rhinitis WANG Guiling，WU Hui，WANG Yuanyuan，YANG Zheng 2016, 8 (3):  280-282.  doi: 10.3969/j.issn.1674-3865.2016.03.010 Abstract ( 292 )   PDF (403KB) ( 126 )   Save Objective: To explore the clinical curative effect of nasal allergy soup combined with meridian massage for allergic rhinitis in children. Methods:  According to the clinic order，68 cases were randomly divided into observation group(38 cases) and control group(30 cases)，who were treated in pediatrics and ENT clinic of Suqian Hospital of TCM and Suqian Children’s Hospital between January to August in 2014.The children in observation group were treated with nasal allergy soup and meridian massage.The others were given inhalation of Beclometasone Dipropionate Aerosol and oral Biyuan Tongqiao granule.The two groups were treated for 20 days,and followed up for more than 12 months.Compare the curative effect,the frequency of attack and symptom score within 12 months of treatment between the two groups. Results: The total effective rate was 89.47% (34/38) in observation group,higher than that of control group［70.00%(21/30)］，and the difference was statistically significant(P<0.05).After treatment,there was a significant difference on the frequency of attack and the symptom score(P<0.05).Compared with the control group,the frequency of attack and the symptom score after treatment in the observation group were significantly better than those in the control group (P<0.05). Conclusion: The treatment of allergy soup combined with meridian massage for allergic rhinitis has a good curative effect，and it was a new way to treat allergic rhinitis in children by traditional Chinese medicine,which was worthy of clinical use. Related Articles | Metrics

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Effect of different enteral nutrition time on nutrition intake and growth and development of very-low-birth-weight infants XIONG Wei,QIU Qizhou,CHEN Hongyu,LIU Renhong,CHENG Guihui 2016, 8 (3):  283-286.  doi: 10.3969/j.issn.1674-3865.2016.03.011 Abstract ( 309 )   PDF (402KB) ( 87 )   Save Objective: To study the effect of different enteral nutrition time on nutrition intake and growth and development of very-low-birth-weight infants. Methods: Totally 130 cases of very-low-birth-weight infants in our hospital from April 2013 to June 2014 were enrolled and divided into 3 groups：≤3d group,4～6d group and ≥7d group，according to different starting time of enteral nutrition.Then milk quantity,total bilirubin levels,body weight and body length were detected|body weight and body length growth rate,and incidence of infection and NEC were compared. Results: (1)Nutritional intake:milk quantity and total bilirubin levels of three groups were different|milk quantity of ≤3d group was higher than that of 4～6d group and ≥7d group|total bilirubin level was lower than that of 4～6d group and ≥7d group.(2)Growth and development condition:body weight and body length growth rate of three groups were not different.(3) Infection:infection rate of ≤3d group was obviously lower than ≥7d group.There was no statistically significance on NEC among three groups. Conclusion: Enteral nutrition 3 days after birth can improve nutrition intake,reduce the incidence of infection,and at the same time it does not affect the growth and development. Related Articles | Metrics

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Clinical effect of low-dose glucocorticoid combined with oral theophylline tablets in the treatment of children with asthma CHEN Qinghai 2016, 8 (3):  286-289.  doi: 10.3969/j.issn.1674-3865.2016.03.012 Abstract ( 470 )   PDF (475KB) ( 177 )   Save Objective: To compare the clinical effect of low-dose glucocorticoid combined with oral theophylline tablets with that of low-dose glucocorticoid combined with long-acting beta2 receptor agonists in the treatment of children with asthma and provide evidence for clinical application of the former. Methods: A total of 82 children with persistent moderate asthma admitted to the Pediatric Department of Baoan TCM Hospital were included in the study，and they were randomly divided into two groups：group A with combination treatment of long-acting beta2 receptor agonists(41 cases) and group B with theophylline(41 cases).Both groups received glucocorticoid treatment|meanwhile，group A was given long-acting beta2 receptor agonists and group B was given theophylline.The treatment course lasted for 12 weeks in both groups.The daytime symptom score，night symptom score and maximum expiratory flow rate were recorded before and after treatment，and the total effective rate was compared between the two groups.The adverse reactions in these two groups were also monitored. Results: The total effective rate was 90.2% in group A and 73.2% in group B，the difference being of statistical significance(P<0.05)|with regard to maximum expiratory flow rate，there was statistical difference before and after treatment in both groups(P<0.01)，but no difference was found between the two groups after treatment(P>0.05).The daytime symptom score and night symptom score were improved a lot after treatment in both groups with statistical significance(P<0.01),but there was no difference between the two groups(P>0.05). Conclusion: The treatment with low-dose glucocorticoid combined with theophylline has definite effect on children with asthma,and its effect is similar to that of glucocorticoid combined with long-acting beta2 receptor agonists.The incidence of adverse reactions is also similar,so it is worthy of clinical application. Related Articles | Metrics

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Clinical effect of modified Wendan decoction in treating phlegm heat type of mesenteric lymphadenitis in children ZHOU Fangfang,SHANG Lili 2016, 8 (3):  290-293.  doi: 10.3969/j.issn.1674-3865.2016.03.013 Abstract ( 303 )   PDF (483KB) ( 95 )   Save Objective: To observe the clinical curative effect of the treatment of regulating qi and eliminating phlegm for phlegm heat type of mesenteric lymphadenitis in children. Methods: From October 2013 to 2014,66 children were treated in Department of Pediatrics of the First Affiliated Hospital of Anhui TCM University for acute mesenteric lymphadenitis(phlegm heat stasis type),and they were randomly divided into the control group and observation group of 33 cases in each.The observation group was treated with traditional Chinese medicine Wendan decoction granules,orally,while control group was given cefprozil granules and Clostridium butyricum live bacteria tablets|treatment lasted for 2 weeks.The total curative effect and the size of abdominal mesenteric lymph nodes were observed in the two groups after treatment. Results: The total effective rate of observation group was 90.9%(30/33),which was significantly higher than that of control group (66.7%,22/33),and the difference was statistically significant(P<0.05).Mesenteric lymph nodes of the two groups in the transverse and longitudinal diameters were significantly reduced,the difference being statistically significant(P<0.05).After treatment,the transverse diameter and longitudinal diameter of mesenteric lymph nodes in the observation group were significantly smaller than those in the control group,and the difference was statistically significant(P<0.05). Conclusion: The modified Wendan decoction in the treatment of phlegm heat type of mesenteric lymphadenitis in children has definite curative effect,which is worthy of promotion. Related Articles | Metrics

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Application value of electrocardiogram in children with allergic purpura complicated with myocardial damage DUAN Lichao，QIAN Haiqin，LIU Yongqing 2016, 8 (3):  293-295.  doi: 10.3969/j.issn.1674-3865.2016.03.014 Abstract ( 875 )   PDF (354KB) ( 114 )   Save Objective: To explore the application value of electrocardiogram in children with allergic purpura complicated with myocardial damage. Methods: Eighty cases of allergic purpura complicated with myocardial damage treated in Pediatric Department of Children′s Hospital of Zhengzhou City were randomly divided into observation group and control group of 40 cases.Control group was detected by routine ECG.The observation group was detected by dynamic electrocardiogram.The detection rate of abnormal ECG and the rate of myocardial damage in patients with allergic purpura were compared between the two groups. Results: Rate of ST-T change,prolongation of the QT interval,sinus bradycardia,and degree Ⅱ sinoatrial block was significantly higher in observation group than that of the control group,the difference being statistically significant(P<0.05)|detection rate of tachycardia,left ventricular hypertension,atrial premature beat,right bundle branch block,degree Ⅰ atrioventricular block and the total ECG change had no statistically significant difference(P>0.05).In observation group,the positive rate of myocardial damage was 97.5% (39/40),higher than the control group［72.5%(29/40)］,the difference being statistically significant(P<0.05). Conclusion: Dynamic electrocardiogram can improve the detection rate of children with allergic purpura and myocardial damage,with higher positive rate of diagnosis,which can effectively determine whether the patients have myocardial damage,so it can be used as an important indicator of clinical diagnosis. Related Articles | Metrics

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Clinical effect of angina No.1 priscription for herpangina YIN Qihui 2016, 8 (3):  296-298.  doi: 10.3969/j.issn.1674-3865.2016.03.015 Abstract ( 497 )   PDF (369KB) ( 110 )   Save Objective: To observe and evaluate the curative effect of angina No.1 prescription for herpangina. Methods: From June to September in 2015,160 children who suffered from herpangina were received and cured in the Department of Pediatrics,Mudanjiang Hospital of Traditional Chinese Medicine,and the children are divided into an observation group and a comparison group randomly,each with 80 children.Children in the observation group took the angina No.1 prescription orally,and Xiyanping injection was intravenously dripped into the children in the comparison group.The course of the treatment lasted for 5 days.Curative effects and adverse reactions of the children in two groups were compared. Results: During the experimental process,5 children in the observation group and 8 children in the comparison group had herpes on hands and feet,and herpes fell off| the observation of 147 children was completed.The total effective rate of the children in the observation group on day 3 and 5 was 88.0%(66/75) and 96.0%(72/75)，which was significantly higher than the control group［76.4%(55/72)，90.3%(65/72)］，and the difference was statistical(P<0.05).The time for fever,rashes and pharyngalgia to be eliminated and the time for WBC counts to return to normal was shorter in the observation group than in the control group,and the difference was statistical(P<0.05).After treatment,the myocardial enzyme CK-MB and C-reactive protein had no statistical difference when compared with before treatment(P>0.05). Conclusion: The clinical effect of the angina No.1 prescription for infantile herpangina is significant. Related Articles | Metrics

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Clinical effect of racecadotril granules combined with saccharomyces boulardii powder on children with autumn diarrhea YAN Haiyan,ZHANG Xiaoli,LI Xiaoqin,YU Jing 2016, 8 (3):  299-301.  doi: 10.3969/j.issn.1674-3865.2016.03.016 Abstract ( 368 )   PDF (348KB) ( 105 )   Save Objective: To study the effect of racecadotril granules combined with saccharomyces boulardii powder on children with autumn diarrhea. Methods: From Aug.2012 to Dec.2014,a total of 160 children with autumn diarrhea who accepted treatment in our hospital were taken as the clinical research objects,and these patients were randomly divided into observation group(80 cases)and control group(80 cases)by random number table method.Patients in the control group were only given saccharomyces boulardii powder,while the other patients in the observation group were given both racecadotril granules and saccharomyces boulardii powder.The treatment lasted for 3 days for both groups. After treatments,we observed and compared their clinical effects. Results: The total effective rate of the observation group after treatment was 93.75%,which was significantly higher than that of the control group(77.50%),and the difference between them was statistiaclly significant(P<0.05). Conclusion: The clinical effect of racecadotril granules combined with saccharomyces boulardii powder on children with autumn diarrhea is good.Thus,it is worthy of clinical application and promotion. Related Articles | Metrics

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Clinical effect of rehabilitation therapy of Chinese medicine combined with botulinum toxin A in children with cerebral palsy WU Zhirong，MA Caiyun，SHANG Qing，ZHANG Jihua 2016, 8 (3):  301-303.  doi: 10.3969/j.issn.1674-3865.2016.03.017 Abstract ( 415 )   PDF (393KB) ( 163 )   Save Objective: To study the clinical effect of rehabilitation therapy of Chinese medicine combined with botulinum toxin A in children with cerebral palsy. Methods: From Mar.2013 to Mar.2015,a total of 80 cerebral palsy children who accepted treatments in our hospital were taken as the clinical research objects,and these patients were randomly divided into observation group (40 cases) and control group (40 cases).Patients in the control group were given rehabilitation therapy of Chinese medicine,and the other patients in the observation group were given rehabilitation therapy of Chinese medicine combined with botulinum toxin A.Six months after treatments,we observed and compared the clinical effects in these two groups. Results: The total effective rate of the observation group was 82.5%(33/40)，which was significantly higher than that of the control group 62.5%(25/40),and the difference was statistically significant(P<0.05).Three months after the end of the treatment,the spasm score was (2.74±0.36) in the observation group,which was significantly lower than that of the control group(3.85±0.33),and the difference was statistical(P<0.05).The incidence of adverse reaction had no statistical difference between the two groups. Conclusion: Rehabilitation therapy of Chinese medicine combined with botulinum toxin A can improve children′s cognitive function and life quality,which has remarkable effect in the treatment of cerebral palsy. Related Articles | Metrics

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Clinical effect of Xiaoer Kechuanling granules combined with ambroxol hydrochloride oral liquid on children with bronchopneumonia HUANG Zhanke,LI Weili,CAI Ming 2016, 8 (3):  304-306.  doi: 10.3969/j.issn.1674-3865.2016.03.018 Abstract ( 1280 )   PDF (359KB) ( 157 )   Save Objective: To study the effect of Xiaoer Kechuanling granules combined with ambroxol hydrochloride oral liquid on children with bronchopneumonia. Methods: From May 2013 to Apr.2015,a total of 80 children with bronchopneumonia who accepted treatment in our hospital were taken as the clinical research objects,and these patients were randomly divided into observation group(40 cases)and control group(40 cases).Patients in these two groups all accepted conventional therapy|in addition,patients in the control group were given ambroxol hydrochloride oral liquid,and the other patients in the observation group were given both ambroxol hydrochloride oral liquid and Xiaoer Kechuanling granules.Five days after treatment,we observed and compared their clinical effects and symptom relief time. Results: The total effective rate of the observation group was significantly higher than that of the control group(P<0.05)|the fever regression time and disappearance time of cough,wheezing and rale of the observation group were all less than those of the control group,and the differences between them were statistically significant(P<0.05). Conclusion: Xiaoer Kechuanling granules combined with ambroxol hydrochloride oral liquid,which has good clinical effect on children with bronchopneumonia,can effectively relieve their clinical symptoms.Thus,it is worthy of promotion. Related Articles | Metrics

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Analgesia effect of intravenous fentanyl citrate puisne acid in neonatal mechanical ventilation GUO Xianfeng,ZHANG Huiyong,FAN Pengju 2016, 8 (3):  306-308.  doi: 10.3969/j.issn.1674-3865.2016.03.019 Abstract ( 300 )   PDF (362KB) ( 112 )   Save Objective: To probe into the analgesia effect of the intravenous fentanyl citrate puisne acid in neonatal mechanical ventilation. Methods: Eighty newborn infants who received mechanical ventilation for respiratory distress syndrome in our hospital from February 2010 to February 2015 were taken as the research objects,and these patients were randomly divided into the control group and the observation group,with 40 patients in each group.In the observation group,they were treated with the intravenous fentanyl citrate puisne acid,while in the control group,they were treated with the vitamin B6 placebo analgesia.Then,the pain was scored by N-PASS,and blood pressure and heart rate of different times were recorded. Results: N-PASS score had no statistical difference between the two groups within one hour(P>0.05).Beginning from 3h of treatment,the N-PASS score of the observation group started to decrease,which was lower at 3h,12h and 24h than the control group,and the differences had statistical significance(P<0.05).The heart rate and blood pressure of the two groups had no significant change in 3h,but significantly decreased beginning from 12h,which were significantly lower in the observation group than in the control group,the difference being statistically significant(P<0.05).After 12h of treatment,the systolic pressure was obviously lower in observation group and the difference had statistical significance(P<0.05). Conclusion: The analgesia effect of the intravenous fentanyl citrate puisne acid in neonatal mechanical ventilation is significant,which can avoid increase of heart rate caused by the pain,and the blood pressure is stable,thus should be promoted in the clinical application. Related Articles | Metrics

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Clinical effects of Xingpi Yanger particle combined with plum-blossom needle on nocturnal crying with syndrome of spleen deficiency and cold attack LI Yanyan,LI Ran,SUN Yanhong 2016, 8 (3):  309-311.  doi: 10.3969/j.issn.1674-3865.2016.03.020 Abstract ( 435 )   PDF (398KB) ( 97 )   Save Objective: To observe the clinical effect of Xingpi Yanger particle combined with plum-blossom needle on nocturnal crying with syndrome of spleen deficiency and cold attack. Methods: Totally 60 patients were randomly divided into two groups:the observation group(30 cases)and the control group(30 cases).The observation group was given Xingpi Yanger particle and plum-blossom needle.The control group was given plum-blossom needle only.The treatment lasted 6 days as a course.Observe the clinical result and the time for symptoms to disappear. Results: The total effective rate of the two groups had no statistical difference(P>0.05).The cure rate of the two groups was statistically different(86.67% vs 63.33%,P<0.05)The symptom onset time and the durage were less in the observation group,and the diffence had statistical significance(P<0.05). Conclusion: The Xingpi Yanger particle and plum-blossom needle is an effective and safe treatment for nocturnal crying with syndrome of spleen deficiency and cold attack. Related Articles | Metrics

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Observation on the effect of Zengshi Kaiwei mixture in the treatment of children with anorexia dysfunoion of spleen GUAN Yannan, LUO Yan 2016, 8 (3):  311-313.  doi: 10.3969/j.issn.1674-3865.2016.03.021 Abstract ( 455 )   PDF (417KB) ( 93 )   Save Objective: To summarize the clinical effect of Zengshi Kaiwei mixture in the treatment of children with anorexia. Methods: A total of 138 children with anorexia were randomly divided into two groups:80 cases in the observation group and 58 in the control group.The observation group was treated with Zengshi Kaiwei mixture,while the control group was treated with Shanpu Jianpi granule.The treatment course was two weeks for both groups,and the treatment effect was compared between the two groups after the course. Results: The total effective rate was 95.00% in observation group and 82.76% in the control group,which was obviously better in the observation group and the difference was of statistical significane(P<0.05). Conclusion: Zengshi Kaiwei mixture has good effect in the treatment of anorexia,and should be clinically applied and promoted. Related Articles | Metrics

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Clinical observation of near stereo visual function in children receiving intermittent strabismus surgery LU Yuebing，CHEN Min，SUN Xiantao 2016, 8 (3):  314-316.  doi: 10.3969/j.issn.1674-3865.2016.03.022 Abstract ( 375 )   PDF (320KB) ( 126 )   Save Objective: To observe the curative effect of intermittent strabismus surgery and the reconstruction of near stereo visual function after operation in children. Methods: From Sep. 2014 to Jan. 2015，150 children were admitted to Zhengzhou Children's Hospital and received correction surgery for intermittent external strabismus. Compare their common visual function and fusion visual function before and after operation，and observe the reconstruction of stereo visual function. Results: The near stereo visual function of these 150 children was significantly improved after operation. Before operation，common visual function was in 70 children，and it was in 120 children after operation，the difference being statistical(P<0.01)|fusion visual function was in 44 children before operation, and 120 children after, the difference being statistical(P<0.01).Before operation, 72 children had near stereo visual function, and after operation 136 children did, and there was statistical difference before and after operation(P<0.01). Conclusion: Surgical treatment has a positive effect on children with intermittent external strabismus. Near stereo visual function can be reconstructed to a certain degree through the operation, which is worth clinically promoting. Related Articles | Metrics

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Effect of early continuous microfeeding and routine intermittent feeding on the nutritional status of low-birth-weight infants LIU Dapeng，GUO Jing，WANG Yingyuan，KANG Wenqing，ZHANG Yaodong，XIONG Hong 2016, 8 (3):  316-318.  doi: 10.3969/j.issn.1674-3865.2016.03.023 Abstract ( 588 )   PDF (399KB) ( 91 )   Save Objective: To observe the effect of early continuous microfeeding and routine intermittent feeding in low-birth-weight infants. Methods: From August 2014 to August 2015, in Zhengzhou Children's Hospital Neonatal Intensive Care Unit, 124 cases of low-birth-weight infants were randomly divided into observation group and control group, each with 62 cases. The control group was given routine intermittent feeding, and the observation group was treated with early continuous microfeeding. The changes of body mass and serum gastrin were observed before and after treatment in two groups. The time for body mass to begin to increase, the time of self sucking, the regression time of jaundice and the incidence of feeding complications were also observed. Results: In observation group the body mass after intervention was (1 673.54±154.27)g and gastrin was (124.82±14.28)ng/L, significantly higher than the control group, whose body mass was (1 395.77±102.54)g and gastrin was (98.79±6.88)ng/L, the difference being of statistical significance(P<0.05). The time for body mass to begin to increase self sucking time, jaundice subsiding time and feeding complication rate in the observation group were better than those of the control group, the difference being statistically significant(P<0.05). Conclusion: The early microfeeding in low-birth-weight infants can improve the feeding tolerance, promote the maturation of the gastrointestinal tract, increase body weight rapidly, and shorten the duration of jaundice, which is worthy of being popularized in clinics. Related Articles | Metrics

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Effect of Beilou Zhisou powder in the treatment of children with chronic cough(dry cough) WANG Xu，GUO Nan 2016, 8 (3):  319-321.  doi: 10.3969/j.issn.1674-3865.2016.03.024 Abstract ( 396 )   PDF (403KB) ( 184 )   Save Objective: To observe the effect of Beilou Zhisou powder in the treatment of children with cough variant asthma with dry cough of respiratory tract. Methods: A total of 100 cases of children with chronic cough who visited the TCM OPD and pediatric OPD of Chang'an Hospital of Dongguan from June 2014 to September 2015 were divided into two groups: TCM group(50 cases) and western medicine group(50 cases). The western medicine group was given routine western treatment of oral-taking of chlorpheniramine maleate tablets, salbutamol sulfate tablets and bromhexine| TCM group was treated with Beilou Zhisou powder. The course lasted for 7 days. Observe the treatment effect in the two groups. Results: The total effective rate was 94%(47/50) in the TCM group, significantly higher than that of the western group(78%,39/50),and there was statistical difference between the two groups(P<0.05). Conclusion: Beilou Zhisou powder has good effect in the treatment of children with cough variant asthma and the dry cough after respiratory tract infection. Related Articles | Metrics

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Observation on the effect of Reduning injection in the treatment of children with pharyngoconjunctival fever CAO Xiaohong 2016, 8 (3):  322-324.  doi: 10.3969/j.issn.1674-3865.2016.03.025 Abstract ( 438 )   PDF (359KB) ( 114 )   Save Objective: To observe the effect and safety of Reduning injection in the treatment of children with pharyngoconjunctival fever. Methods: A total of 66 cases of pharyngoconjunctival fever in children were selected and divided into two groups by random number table method:the observation group(33 cases) and the control group(33 cases).The control group received treatment of Yanhuning powder-injection,   0.08~0.29 each time,which was added to 250 mL of  5% glucose injection for intravenous dripping|the treatment lasted for 3 days. Results: was used for treatment in the observation group, 20 mL of which was added to 250 mL of normal saline injection,once a day,and the treatment lasted for 4 days,Compare the treatment effect between the two groups at the end of the course.Results:The total effective rate was 93.94% in the observation group,which was better than of the control group(66.67%),the difference being of statistical significance(P< 0.05).The observation group was better than the control group in the following aspects:clinical abatemen of fever,disappearance of sore throat and pharyngoconjunctival congestion,and hospital stay,and there was statistical diffence between the two groups(P< 0.05).The rate of adverse reactions was 6.06% in the observation group,and it was better than than in the contril group(27.27%),the difference being statistical(P<0.05). Conclusion: Reduning Injection has  great effect in the treatment of children with pharyngoconjunctival fever with high safety,which is of practical value of promotion in clinics. Related Articles | Metrics

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Effects of rehabilitation intervention time on recovery of limb function in children with severe brain injury XIN Zhixiong,LIU Zhenhuan,TANG Canquan 2016, 8 (3):  324-326.  doi: 10.3969/j.issn.1674-3865.2016.03.026 Abstract ( 415 )   PDF (397KB) ( 170 )   Save Objective: To observe the effect of rehabilitation intervention time on the recovery of limb function of children with severe brain injury. Methods: A retrospective analysis of 100 cases of children with severe brain injury was performed|depending on the intervention time they were divided into intervention group(58 cases)and observation group(42 cases)|the former was given rehabilition intervention treatment after 48 hours,and the latter was given early rehabilitation therapy within 48 h|two groups were observed before and after treatment for GCS score changes and recovery of limb function. Results: After treatment,the in GCS score observation group［(4.58±0.13)points］was higher than the control group［(3.55±0.11)points］,the difference being statistically significant(P<0.05)|the total effective rate in the observation group(92.86%)was significantly higher than that in the control group(68.97%),the difference being statistically significant(P<0.05). Conclusion: The study shows that for the children with severe brain injury,early rehabilitation intervention therapy can achieve remarkable results,effectively promote the recovery of limb function,and improve the quality of their prognosis. Related Articles | Metrics

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Effect of ambroxol hydrochloride combined with procaterol hydrochloride in the treatment of children with pneumonia MA Zhongxia 2016, 8 (3):  327-329.  doi: 10.3969/j.issn.1674-3865.2016.03.027 Abstract ( 1714 )   PDF (357KB) ( 150 )   Save Objective: To summarize the clnical effect of ambroxol hydrochloride Combined with procaterol hydrochloride in the treatment of children with pneumonia. Methods: A total of 150 children with pneumonia were chosen and were divided into two groups according to their admission number:the control group and the observation group.The control group was given routine treatment,while The observation group was treated with ambroxol hydrochloride in combination with procaterol hydrochloride|the treatment course was 14 days for both groups.At the end of the course,the clinical effect was compared between the two groups. Results: The total effective rate in the observation group was significantly higher than the control group with statistical differnce(P< 0.05)|the rate of adverse reactions was obviously lower in the observation group than in the control group,the difference being of statistical significance(P<0.05). Conclusion: Ambroxl hydrochloride combined with procaterol hydrochloride has good effect and fewer adverse reactions in the treatment of children with pneumonia,and it can improve the prognosis of these children,which is worthy of popularization. Related Articles | Metrics

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Role of food allergy in the pathogenesis of functional gastrointestinal diseases in infants HUANG Runxiao，LI Hanming，LIANG Yuhua 2016, 8 (3):  329-331.  doi: 10.3969/j.issn.1674-3865.2016.03.028 Abstract ( 390 )   PDF (359KB) ( 109 )   Save Objective: To investigate the role of food allergy in the pathogenesis of functional gastrointestinal disease. Methods: Totally 400 patients with suspected allergy in children who were treated in our hospital from March 2014 to August 2015 were divided into two groups according to their clinical symptoms. The suspected food allergy with gastrointestinal symptoms, such as nausea, vomiting, irritability, crying, abdominal pain and other characteristics according to Rome Ⅲ diagnostic criteria, were classified as functional gastrointestinal disease group(220 cases)| the remaining 180 cases mainly with skin allergy symptoms, such as eczema, papular, nettle rash and other symptoms, were classified as the skin allergy group. ELISA assay was used to determine allergen specific IgE and chemiluminescence method was used to determine the serum total IgE. Results: Of the 400 cases, serum total IgE was less than 100 IU/mL in 145 cases, accounting for 36.25%, 100～200 IU/mL in 83 cases(20.7%),>200 IU/mL in 172 cases(43.0%). The positive rate of serum total IgE was 63.75%(255/400),which was 61.36%(135/220) and 66.66%(120/180) respectively in functional gastrointestinal diseases group and skin allergy group(P>0.05). In the two groups, there were 258 cases of sIgE positive serum, the total positive rate of sIgE being 64.5%(258/400). Food allergy rates were: eggs(white+yellow) the highest, followed by milk, beef and mutton, seafood，nuts and fruit in turn. Positive serum sIgE was in 143 cases in the group of functional gastrointestinal diseases, and the positive rate of sIgE was 65%. There were 115 cases of sIgE positive in skin allergic group, and the positive rate of sIgE was 63.89%. There was no significant difference in serum sIgE positive rate between the two groups(P>0.05). Conclusion: Food allergy can cause skin allergy symptoms, and some of the children also have the symptoms of functional gastrointestinal disease. It is necessary to ask in detail about the diet history and detect allergen in children with functional gastrointestinal disease, if you consider it is related to food allergy. This is helpful in finding the cause of food allergies in children, who can be given etiological treatment. Related Articles | Metrics

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Effects of lidocaine surface anesthesia on postoperative analgesia and stress reactions of children receiving tonsillectomy LIANG Hongling 2016, 8 (3):  332-335.  doi: 10.3969/j.issn.1674-3865.2016.03.029 Abstract ( 497 )   PDF (462KB) ( 102 )   Save Objective: To explore the effects of lidocaine surface anesthesia on postoperative analgesia and stress reactions of children receiving tonsillectomy. Methods: A total of 86 cases of children receiving tonsillectomy in our hospital from September 2012 to May 2014 were selected as the research subjects, who were divided into observation group and control group according to the random number table method, with 43 cases in each group. On the basis of routine anesthesia, the control group was given normal saline wound spray, and the observation group was given lidocaine surface anesthesia. The blood pressure(BP), heart rate(HR), respiration(RR), arterial oxygen saturation(SaO2) and pain scores of children in the two groups after drug spraying, immediately after waking, after 10 min, 30 min and 60 min of waking, were observed and recorded, and the stress reactions were analyzed by observing the adrenal cortical hormone(ACTH), interleukin-6(IL-6) and cortisol(COR) levels in the two groups before and after operation. Results: There were no significant differences in the levels of BP,HR,RR,SaO2 and pain scores between the two groups after drug spraying and after 60 min of waking(P>0.05),but observation group was significantly lower than the control group in those indexes immediately after waking, after 10 min, and 30 min of waking(P<0.05).There were no significant differences in the levels of ACTH, IL-6 or COR in the two groups before operation(P>0.05),but the observation group was better in these indexes than the control group after operation(P<0.05). Conclusion: The application of lidocaine surface anesthesia can significantly reduce the degree of pain and stress reactions after tonsillectomy, which has very significant improvement effects. Related Articles | Metrics

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Clinical effect of mucosolvan given in different ways in the treatment of neonatal pneumonia ZHANG Zhuanfang 2016, 8 (3):  335-337.  doi: 10.3969/j.issn.1674-3865.2016.03.030 Abstract ( 420 )   PDF (407KB) ( 100 )   Save Objective: To investigate the clinical effect of mucosolvan given in different ways in the treatment of neonatal pneumonia. Methods: Totally 86 cases of neonatal pneumonia were selected in the Pediatric Department of People′s Hospital of Ruyang County from Aug.2012 to Oct.2014,and according to the different treatment options they were divided into control group and observation group,43 cases in each group.The control group was given constant temperature incubator,oxygen,anti-infection,correction of acid-base imbalance,energy mixture of nutritional support and other conventional symptomatic treatment.At the same time,intravenous infusion of mucosolvan treatment was given.The observation group was given mucosolvan inhalation therapy in addition to the above treatment.The treatment time,clinical efficacy and adverse drug reactions were observed and compared between the two groups. Results: There was no significant difference in the total effective rate between the two groups(P>0.05).The cure rate of observation group was 95.4%(41/43),significantly higher than that of the control group［79.1%(34/43)］,the difference being statistically significant(P<0.05).In the observation group,treatment time was(7.4±2.1)d,significantly shorter than the control group(10.4±2.9)d,the difference being statistically significant (P<0.05).Adverse drug reactions were mild in the two groups during the treatment period,the difference being not statistically significant(P>0.05). Conclusion: Mucosolvan aerosol inhalation combined with intravenous use can control clinical symptoms quickly,shorten the treatment time and improve the cure rate.It is safer and has no obvious adverse drug reactions. Related Articles | Metrics

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Clinical effect of astragalus granule combined with loratadine on children with cough variant asthma WANG Minzhi，YANG Cuifen，YAN Hongli，WANG Qishan 2016, 8 (3):  338-340.  doi: 10.3969/j.issn.1674-3865.2016.03.031 Abstract ( 590 )   PDF (344KB) ( 95 )   Save Objective:To study the effect of astragalus granule combined with loratadine on children with cough variant asthma. Methods:From Jul.2013 to Jun.2015,a total of 80 children with cough variant asthma who accepted treatment in our hospital were taken as the clinical research objects,and these patients were randomly divided into observation group(40 cases)and control group(40 cases).Patients in the control group were only given astragalus granule,and the other patients in the observation group were given both astragalus granule and loratadine.After treatment,we observed and compared their clinical effects and improvement of symptoms. Results:Three weeks after treatment,the clinical effect of the observation group was better than that of the control group(P<0.05)|the attack times of asthma and,cough and wheezing disappearance time of the observation group were all less than those of the control group,and the differences between them were statistically significant(P<0.05). Conclusion:Astragalus granule combined with loratadine,which has good clinical effect on children with cough variant asthma,can effectively relieve their clinical symptoms. Related Articles | Metrics

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Analysis of the high risk factor in 238 cases of infantile convulsion HUANG Yanfang,ZHANG Li,HE Wei 2016, 8 (3):  340-342.  doi: 10.3969/j.issn.1674-3865.2016.03.032 Abstract ( 288 )   PDF (367KB) ( 127 )   Save Objective:To study the high risk factor and prevention measure of infantile convulsion. Methods:A total of 238 cases of children with convulsion were admitted to our hospital from October 2012 to December 2014,and all the children′s age,gender,and other causing factors were statistically recorded.The related influence factors were analyzed and prevention measures of infantile convulsion were summarized. Results:Most children had convulsion attack at 1 to 3 years old,whose rate was statistically higher than the other age group (P<0.05),but there was no significant difference between boys and girls(P>0.05).Most infantile convulsion was caused by high fever,seizure,infection and low calcium,and the rate of convulsion due to high fever was significantly higher than the other factors (P<0.05)|the rate of convulsion caused by epilepsy and brain infection was higher than low calcium and other factors(P<0.005)|all differences were of statistical significance. Conclusion:The most common reason of children with convulsion is high fever convulsion,which is likely to occure among children aged 1~3,and it needs timely prevention. Related Articles | Metrics

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Investigation on blood lead level of children aged 0-6 in Nanshan District of Shenzhen city and analysis of related risk factors LIANG Wanxia，YIN Xiaolei，YU Xiuhong 2016, 8 (3):  343-345.  doi: 10.3969/j.issn.1674-3865.2016.03.033 Abstract ( 291 )   PDF (413KB) ( 96 )   Save Objective:To investigate the blood lead level and related risk factors of children aged 0-6 in Nanshan District of Shenzhen city,and to explore the preventive measures of risk factors. Methods:The blood lead levels were measured in 4 325 children aged 0-6 in Nanshan District of Shenzhen city from December 2013 to December 2015. Results:In children aged 0 to 6 in Nanshan District,4-5-year old,5-6-year old children had the highest incidence of high blood lead,and compared with other age groups，there was significant difference(P<0.05).The incidence of high blood lead in male children was 15.61% (400/2 562),higher than that of girls (164/1 763),and the difference was statistically significant (P<0.01).The blood lead level in boys was (29.2±12.9)μg/L,which was significantly higher than that of girls［(27.1±11.8)μg/L］,and the difference was statistically significant(P<0.05).The risk factors mainly included the passive smoking,family environment,health habits and eating habits. Conclusion:In order to prevent the diseases related to high level of blood lead in children and to promote effective decrease in the amount of lead in the blood,children should be kept away from exposure to lead-polluted goods and foods with a high content of lead,and they should also be educated to develop good eating habits and health habits. Related Articles | Metrics

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Investigation and cause analysis of anorexia in 80 children with cerebral palsy TANG Fangfang，WEI Cheng，CHEN Ying，ZHANG Chunlin 2016, 8 (3):  346-347.  doi: 10.3969/j.issn.1674-3865.2016.03.034 Abstract ( 323 )   PDF (284KB) ( 127 )   Save Objective:To sum up the causes of anorexia in children with cerebral palsy in order to guide clinical treatment and provide family guidance for parents of children with cerebral palsy. Methods:A total of 80 children with cerebral palsy who were diagnosed with anorexia and received rehabilitation training in Nanning Children′s Rehabilitation Center from March 2014 to August 2015 were included in the study.Questionnaire survey was performed in their parents and the causes were analyzed. Results:There were 80 cases of movement disorder(100%),53 cases of improper diet(66.2%),46 cases of oral barrier(56.2%),37 cases of mental factor(46.2%),35 cases of caries(43.7%),23 cases of trace element deficiency(28.7%) and 16 cases of delayed food supplement(20%). Conclusion:The main causes of anorexia in children with cerebral palsy are movement disorder,oral barrier,improper diet,mental factor,caries and trace element deficiency. Related Articles | Metrics

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Clinical features and epidemiological analysis of adenovirus infection in children with diarrhea HUANG Liang，WU Xia，JIANG Huiying 2016, 8 (3):  348-350.  doi: 10.3969/j.issn.1674-3865.2016.03.035 Abstract ( 298 )   PDF (342KB) ( 117 )   Save Objective:To probe into the clinical features and epidemiological characteristics of adenovirus infection in children with diarrhea. Methods:The stool samples of children under 5 years of age from January 2013 to December 2014 in Nanshan District,Shenzhen，were collected,and the positive specimen were sequentially analyzed and genotype was typed through the detection of adenovirus by polymerase chain reaction,and at the same time,the relationship between adenovirus infection and age,season and so on were analyzed. Results:Totally 600 specimens were detected in 20 cases of adenovirus infection,the positive rate being 3.33%.In the adenovirus positive samples,there were 14 cases of intestinal adenovirus,and all were Ad41 type,accounting for 70%.Non-intestinal adenovirus was detected in 6 cases,accounting for 30%.The course of disease of enteric adenovirus was (11.24±3.53)d,which was significantly longer than that of non-enteric adenovirus［(6.67±2.41)d］,and the difference was statistically significant(P<0.05).In addition,there was no significant difference between the two groups concerning frequency of vomiting and fever(P>0.05).The adenovirus infectious diarrhea in the whole year,which peaked in October and May,and the peak in May(April to June) was the most,accounting for 65%(13/20).The adenovirus infectious diarrhea could occur in all ages,with >6~12 years of age being the most common,accounting for 65%(13/20). Conclusion:Intestinal adenovirus type 41 is an important pathogen causing diarrhea in children in Nanshan District of Shenzhen,and to strengthen the monitoring is of great significance to the timely diagnosis and treatment,which improves the prognosis of children. Related Articles | Metrics

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Retrospective investigation and summary of syphilis transmission blocking from mother to baby LYU Yunhong，LI Xin 2016, 8 (3):  351-353.  doi: 10.3969/j.issn.1674-3865.2016.03.036 Abstract ( 346 )   PDF (367KB) ( 123 )   Save Objective:To study the results of intervention for syphilis infection in mothers and infants so as to summarize the experience and shortage. Methods:A retrospective analysis was made on the results of syphilis infection in mothers and infants from October 2012 to September 2013. Results:The intervention rate of syphilis in mothers was 85%(17/20) in 2012 and 95.65%(22/23) in 2013.The high TRUST titre was related to stillbirth. Conclusion:Free testing and intervention can block the syphilis transmission from mothers to infants.In order to block the transmission permanently,it is necessary to do a good job in publicity and education to improve the self-protection sense in the high-risk population. Related Articles | Metrics

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Clinical analysis of the screening for congenital hypothyroidism in moderate and high-risk neonates in NICU ZHAO Lihong 2016, 8 (3):  353-355.  doi: 10.3969/j.issn.1674-3865.2016.03.037 Abstract ( 311 )   PDF (435KB) ( 83 )   Save Objective:To study the incidence of congenital hypothyroidism in moderate-and high-risk neonates in NICU. Methods:A total of 230 high-risk neonates were treated in NICU of No.8 Hospital of Baotou from June 2013 to June 2015.On 3～7 d after birth，the thyroid function was detected，including thyroxin，T3 and T4.According to the Diagnosis and Treatment Guidelines to Thyroid Diseases During and After Pregnancy published in 2012，the diagnosis was made and treatment was performed. Results:There were 5 cases meeting the diagnosis standard of primary subclinical hypothyroidism，the positive detection rate being 1/46. Conclusion:The proportion of congenital hypothyroidism cases in NICU is relatively high，and subclinical and temporary hypothyroidism is more common.Therefore it′s necessary to pay attention to screening and to follow the thyroid indexes，and proper treatment can be given in time of need.However，a larger sample is needed for clinical research to determine whether it can be regarded as a routine screening. Related Articles | Metrics

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Analysis of the causes of death in children under 5 years old in the Heping District of Shenyang City in the recent ten years GAO Xin 2016, 8 (3):  356-358.  doi: 10.3969/j.issn.1674-3865.2016.03.038 Abstract ( 336 )   PDF (323KB) ( 100 )   Save Objective:To reduce the mortality of children under 5 years of age,to understand the cause of death,and to analyse the monitoring data. Methods:Describe the trends in mortality,perform analysis of death causes,and use the grey model［GM (1,1)］ and BP artificial neural network to predict mortality. Results:The total mortality in children under five years old was decreased,being lower in the recent 4 years,with a certain degree of volatility and occasional increases.The main cause of death was premature low birth weight,congenital heart disease and other congenital anomalies,with the death due to injury ranking higher.The average error rate of the BP artificial neural network method was 2.68%,which was much lower than that of the grey model(14.06%). Conclusion:We should strengthen prevention and health care work in premature low weight,congenital heart disease and other congenital anomalies and pay attention to prevention of child injury in order to ensure the existing achievement of mortality decline.BP artificial neural network method is better than the grey model method. Related Articles | Metrics

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Thinking about strengthening the rational use of medicine and health education of traditional Chinese medicine for children at asthma seedling stage DING Lizhong，SUN Liping，WANG Yanbo 2016, 8 (3):  359-361.  doi: 10.3969/j.issn.1674-3865.2016.03.039 Abstract ( 334 )   PDF (457KB) ( 112 )   Save The theory of asthma seedling stage creatively moves the prevention and treatment of asthma forward to the stage of no wheezing roles or dyspnea.It is the key strategy in the prevention and treatment of asthma to strengthen the drug therapy and TCM health education at asthma seedling stage in children，which can effectively prevent the typical attack of asthma.Base on these analyses，the paper introduced the symptomatic treatment by rational use of drugs and the treatment with Modified Anti-asthma Decoction or Yiqi Guben Capsule.In addition，various practice of TCM health education were launched based on reducing milk and food，preventing coldness，paying attention to living，taking proper exercise，differentiating TCM physique and regulating the physique. Related Articles | Metrics

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Analysis of the prescriptions and syndromes of Lonicerae and Forsythiae powder and warm-heat disease in children SHI Lei，WANG Wenli 2016, 8 (3):  361-363.  doi: 10.3969/j.issn.1674-3865.2016.03.040 Abstract ( 329 )   PDF (458KB) ( 130 )   Save Lonicerae and Forsythiae powder is a well-known prescription by Wu Jutong,a famous specialist in warm-heat disease of Qing-dynasty.It is effective in relieving fever and expel poison,and is regarded as the first-choice in managing warm-heat disease,which plays an important role in the clinical practice.In this paper,by way of literature combing,we have sorted out the literature about infantile warm-heat diseases and Lonicerae and Forsythiae powder,explain the prescription and its application in the treatment of the diseases.In Differentiation of Warm-heat Diseases,the powder was used in the treatment of many warm-heat syndromes in children.The doctors of later ages have modified the prescription and further broadened its application scope,making it more important in modern clinical practice of dealing with warm-heat diseases,respiratory diseases and viral infections in children. Related Articles | Metrics

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Experience of Prof. Ma Rong in skillfully using Yinqiao powder to treat children with epilepsy and tics disorders ZHANG Xilian,ZHANG Meijing,LI Rui 2016, 8 (3):  364-366.  doi: 10.3969/j.issn.1674-3865.2016.03.041 Abstract ( 630 )   PDF (474KB) ( 124 )   Save Yinqiao powder is a pungent,cool and moderate prescription.It′s derived from "Wenbing Tiaobian" written by Wu Jutong in the Qing dynasty.The classical prescription is widely used in a variety of diseases with early differentiation of wind-heat evidence of guilty,especially in the respiratory diseases.Mentor prof Ma Rong has been engaged in the research of nervous system diseases such as epilepsy and tics disorders in children for more than 30 years,and has accumulated a wealth of experience.His ingenious application of Yinqiao powder in the treatment of epilepsy and tics disorders has gained good curative effect. Related Articles | Metrics

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Value analysis of bird nest type nursing in very-low-birth-weight infants ZHANG Yingli 2016, 8 (3):  366-368.  doi: 10.3969/j.issn.1674-3865.2016.03.042 Abstract ( 396 )   PDF (428KB) ( 110 )   Save Objective:To investigate the clinical effect of bird-nest-type nursing in very-low-birth-weight infants. Methods:A total of 84 cases of very-low-birth-weight infants in our hospital were divided into two groups by random double-blind method:42 cases in control group was given conventional nursing,and 42 cases in observation group was added bird-nest-type nursing.The nursing course was 20 days for both groups.Observe and compare the clinical effect of the two groups. Results:Recovery time of birth weight of observation group was(7.58±2.43)d,incubator time was(13.67±2.84)d,jaundice regression time was(12.78±2.49)d and hospital stay was(20.56±1.82)d,which were all obviously shorter than those of the control group(P<0.05).The incidence rates of apnea(4.76%),skin damage(2.38%),asphyxia(0.00%),hard swollen(2.38%)and feeding intolerance(14.29%)in observation group were all obviously lower than those of control group(P<0.05). Conclusion:The bird-nest-type nursing for very-low-birth-weight infants has significant effect and is beneficial to the growth and development of children.It is worthy of wide application. Related Articles | Metrics