Table of Content

25 February 2020, Volume 12 Issue 1 Previous Issue    Next Issue

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Effect of Ganmai Dazao decoction combined with inosine and vitamin B complex in the treatment of children with Tourette′s syndrome:an observation on 56 cases 2020, 12 (1):  1-3.  doi: 10.3969/j.issn.1674-3865.2020.01.001 Abstract ( 964 )   PDF (456KB) ( 65 )   Save Objective To observe the clinical effect of Ganmai Dazao decoction combined with inosine and vitamin B complex in the treatment of children with Tourette′s syndrome Methods A total of 56 children with Tic disorder were treated in our hospital from June 2018 to May 2019,and they were given Ganmai Dazao decoction combined with inosine and vitamin B complex for treatment,four weeks as a course After 2 courses of treatment,the effect was evaluated Results The treatment was significantly effective in 32 cases,effective in 17 cases and ineffective in 7 cases,with the total effective rate being 87.5% Conclusion Ganmai Dazao decoction combined with inosine and vitamin B complex has significant effect in the short term in the treatment of children with Tourette syndrome。 Related Articles | Metrics

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Analysis of the medication rules of Professor Hou Jianghong in the treatment of diarrhea in children 2020, 12 (1):  4-7.  doi: 10.3969/j.issn.1674-3865.2020.01.002 Abstract ( 199 )   PDF (500KB) ( 58 )   Save Objective To analyze the medication rules of Professor Hou Jianghong in the treatment of diarrhea in children. Methods Totally 186 prescriptions in the outpatient medical records from June 2016 to April 2019 were collected for descriptive statistical analysis,and the frequency of meridian tropism,efficacy classification,four Qi and five flavors of drugs was analyzed at the same time. Results In Prof Hou Jianghong′s treatment for children′s diarrhea,many drugs (Poria cocos,Atractylodes macrocephala,lentils,etc.) were used to strengthen the spleen and transport the spleen,mainly including tonic drugs,diuretic drugs and dampnessresolving drugs;most of the drugs were warm,and the flavors of the drugs were mostly pungent and sweet. Conclusion Professor Hou Jianghong′s treatment for infantile diarrhea is mainly based on invigorating Qi and spleen and warming the stomach. The drugs are mainly mild in nature and function through spleen and stomach. Related Articles | Metrics

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Professor Hu Tiancheng′s medication rules in treating children with spleenstomach syndrome 2020, 12 (1):  7-11.  doi: 10.3969/j.issn.1674-3865.2020.01.003 Abstract ( 213 )   PDF (754KB) ( 52 )   Save Objective To mine and analyze Prof Hu Tiancheng′s (a prestigious Chinese physician) medication rules and experience in diagnosis and treatment of children with spleenstomach syndrome Methods The child cases of spleenstomach syndrome treated in the outpatient department by Prof Hu Tiancheng were collected The datamining methods,such as clustering,association and ward calculation,were used to study and summarize Prof Hu′s medication rules in treating children with spleenstomach syndrome Results A total of 310 prescriptions were selected,involving 115 kinds of Chinese medicines,with the frequency of application being 3 458,11.15 kinds/time per prescription Sixteen kinds of highfrequency (core) drugs were chosen;four kinds of core prescriptions were obtained by clustering analysis;six pairs of commonly used drugs were excavated Conclusion Prof Hu Tiancheng′s medication rules in the differentiated treatment of children with spleenstomach syndrome have been primarily obtained He focuses on the dependence of intake and digestion,the combination of dryness with dampness,aiming to recover the function of spleen and stomach He′s precise in choosing drugs and flexible in using them The function of spleen and stomach in children is weak,so Prof Hu is careful in using some stimulating drugs and pays attention to the regulation of Qi,and he has a lot of experience in the treatment Related Articles | Metrics

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Present clinical application of Xiyanping injection in pediatric field 2020, 12 (1):  12-16.  doi: 10.3969/j.issn.1674-3865.2020.01.004 Abstract ( 269 )   PDF (789KB) ( 70 )   Save Xiyanping injection is a watersoluble preparation of andrographolidesulfonate,which has antiinflammatory,antibacterial and antiviral effect It also has the effect of protecting liver and gallbladder,regulating immune function and fighting against platelet aggregation and neoplasm It inhibits the release of inflammatory factors by inhibiting mononuclear phagocytes and enhancing the phagocytosis of macrophages;it decreases the release of cytokines,prevents the wrapping of DNA segment by protein,and inhibits the copying of viruses,so as to play a significant role in antiinflammatory,antibacterial and antiviral actions Therefore,it has been widely used in the treatment for viral and/or bacterial infectious diseases in respiratory,digestive,and nervous systems,and the effect is significant However,it is also pointed out in some related literatures that in the clinical application of Xiyanping injection,due to the individual differences of children during growth and development,and because Xiyanping is a Chinese preparation,which can activate complements to produce allergic toxin and induce the release of histamine after the large molecular weight protein enters the human body,there is taboo in compatibility and difference in dose,so some children have adverse reactions after being given Xiyanping injection,such as damage to the skin and its appendages stomach discomfort,abdominal pain and diarrhea Therefore,when Xiyanping injection is used,it is necessary to strictly assess the indications and contradications,carefully inquire the drug allergic history,give the proper dose and enhance the observation and monitoring during transfusion in order to avoid the occurrence of adverse reactions Related Articles | Metrics

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Study on antipyretic effect of Buzhong Yiqi decoction in children with acute upper respiratory tract infection 2020, 12 (1):  17-20.  doi: 10.3969/j.issn.1674-3865.2020.01.005 Abstract ( 229 )   PDF (509KB) ( 68 )   Save Objective To analyze the effects of Buzhong Yiqi decoction in the treatment of children with acute upper respiratory tract infection and fever,such as enhancing the antipyretic effect,shortening the time of complete fever abatement and reducing the number of repeated fever Methods A retrospective analysis was carried out in 83 children with acute upper respiratory tract infection complicated with fever treated at pediatric outpatient department of Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine from March 2018 to June 2019 Based on whether they take the decoction,the children were divided into two groups:43 in the TCM group and 40 in the conventional group The children in the conventional group were given ibuprofen suspension to relieve fever in addition to the antiinflammation and rehydration treatment The children in Traditional Chinese Medicine(TCM) group were treated with Buzhong Yiqi decoction besides the treatment for conventional group to bring down the fever The clinical efficacy,antipyretic time and number of repeated fever were compared between the two groups Results There was no significant difference in the total effective rate or the 3d cure rate between the two groups（P>0.05） The number of children in the TCM group whose temperature recovered to normal within 3 days without recurrence of fever within 3 days was significantly higher than those in the conventional group(P<0.05) There was no significant difference in the mean time of fever abatement or the mean time of fever abatement or the onset time of fever abatement between TCM group and the conventional group（P>0.05）,but the number of fever recurrence and the time of complete fever abatement in TCM group were significantly less than those in the conventional group,and the difference was statistically significant (P<0.05) Conclusion In the clinical treatment for children with acute upper respiratory tract infection complicated with fever,the use of Buzhong Yiqi decoction as an adjunctive antipyretic therapy on the basis of routine treatment can enhance the clinical therapeutic effect,shorten the complete antipyretic time,reduce the number of repeated fever,and promote the rehabilitation of children Related Articles | Metrics

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Progress in diagnosis and treatment of children with thyroid disease 2020, 12 (1):  21-24.  doi: 10.3969/j.issn.1674-3865.2020.01.006 Abstract ( 129 )   PDF (609KB) ( 94 )   Save To explore the effect of Chinese and Western medications on thyroid disease (rickets) in children,and to provide more efficient diagnosis and treatment methods for children with thyroid disease The literature of ancient and modern doctors on the methods in the diagnosis and treatment of thyroid diseases in children was analyzed and compiled Traditional Chinese and Western medicine have relatively little knowledge about pediatric thyroid diseases,and each has its own advantages and disadvantages in the treatment methods. The thyroid disease in children seriously affects their growth and intellectual development,which should be concerned and paid attention to. Related Articles | Metrics

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Early clinical manifestation and etiological analysis of neonatal urinary tract infection 2020, 12 (1):  24-27.  doi: 10.3969/j.issn.1674-3865.2020.01.007 Abstract ( 219 )   PDF (465KB) ( 50 )   Save Objective To explore the early clinical manifestations,empirical selection of antibiotics,and etiological analysis of neonatal urinary tract infection,and to summarize how to identify neonatal urinary tract infection as early as possible and how to select antibiotics reasonably in the early stage Methods The clinical data of 43 neonates diagnosed with neonatal urinary tract infection in neonatal ward of our hospital from January 2017 to October 2018 were retrospectively analyzed The main complaints,blood routine and urine routine within 24h of admission,empirical selection of antibiotics,midstream urine culture pathogen,drug susceptibility test,hospitalization time,and prognosis of neonatal urinary tract infection were collected for analysis and summary Results There were 22 cases of female children and 21 cases of male children in the study There was no significant difference in the incidence between the male and female The main clinical manifestations were jaundice(15 cases),fever(14 cases),cyanosis and abdominal distention (3 cases each) Among them,fever was more than 38 degrees in 13 cases,jaundice duration was prolonged to more than 15 days in 3 cases,or jaundice occurrence time was delayed over 7 days in 10 cases Urine culture was positive in 7 cases The blood routine and CRP and PCT indices were not uniform,but the patients with positive midstream urine culture usually had typical symptoms or positive indexes for severe infection Escherichia coli was the most common pathogen(71.4%,5/7),which was 100% sensitive to amoxicillin,clavulanate,meropenem and levofloxacin It was highly resistant to ampicillin,cefazolin and paracillin(80%) It was also resistant to common antibiotics The resistance rates to ceftriaxone and ceftazidime were 40% and 20% Conclusion The clinical manifestations of neonatal urinary tract infection are in lack of characteristics,and the main symptoms are systemic symptoms The patients with prolongation of fever and jaundice or the delayed occurrence of jaundice need to complete urinary routine and midstream urine culture as soon as possible;blood routine + CRP and PCT can not be used as diagnostic indicators of urinary tract infections,but can indicate the severity of the disease;the positive pathogens are mostly Gramnegative bacilli,mainly Escherichia coli The drug resistance rate is high. Related Articles | Metrics

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Retrospective analysis of methylprednisolone in the treatment of children with refractory Mycoplasma pneumoniae pneumonia 2020, 12 (1):  28-32.  doi: 10.3969/j.issn.1674-3865.2020.01.008 Abstract ( 192 )   PDF (561KB) ( 36 )   Save Objective To analyze the clinical characteristics of refractory Mycoplasma pneumoniae pneumonia(RMPP),in different effect response to treatment by observing the 35d effects in the initial treatment with conventional dose of methylprednisolone Methods Retrospective analysis was performed on the clinical data of 127 cases of RMPP patients treated in Dalian Municipal Women and Children′s Medical Center from January 2015 to December 2018 According to initial 35d effects of 2 mg/(kg·d) methylprednisolone,the dose was further adjusted,and patients were divided into 3 groups,“conventional” group,“highdose” group and “longcourse” group The clinical features,radiological features,laboratory examination and prognosis of the cases were compared Results （1）The rates of respiratory failure,extrapulmonary complications,cloudy opacity,lobar lung consolidation and necrotizing pneumonia in the three groups were statistically different(P<0.05);the incidence of extrapulmonary complications in “highdose” group was higher than the other two groups(P<0.017),and severe extrapulmonary manifestations were predominant in “highdose” group(26/31),but extrapulmonary manifestations of the other two groups were mainly mild(6/9,41/55) There was no significant difference in rates of wheezing,allergic diseases,family allergic diseases,mixed infection,diffused interstitial changes,acute pulmonary effusion,atelectasis among the three groups(P>0.05)（2）The levels of lactic dehydrogenase and serum ferritin in the three groups were statistically different(P<0.01),and they were higher in the “highdose” group than in the other two groups(P<0.01) The level of fibrinogen in the three groups was statistically different(P<0.05),and it was higher in the “highdose” group than in “conventional” group(P<0.05) Comparing the Creactive protein of the three groups,the level of Creactive protein in “highdose” group was higher than that in “conventional” group(P<0.05)There was no significant difference in levels of white blood cell count,percentage of neutrophils,eosinophil count,creatine kinase isoenzyme or DDimer among the three groups(P>0.05) （3）In 6 months of followup after treatment,the rates of lung consolidation and interstitial changes in the three groups were statistically different(P<0.05),and they were higher in the “highdose” group than in the “conventional” group(P<0.017) There were no significant differences in rates of atelectasis or wheezing among the three groups in the 6month followup (P>0.05) Conclusion Conventional dose of methylprednisolone may be ineffective in RMPP cases with respiratory failure,severe extrapulmonary complications,lobar lung consolidation,and necrotizing pneumonia significant increase of lactic dehydrogenase,serum ferritin,fibrinogen and Creactive protein,and these cases may have high risk of lung sequelae It is recommended to give highdose methylprednisolone,immunoglobulin,anticoagulation combined with bronchoscopic treatment,and to make regular reexamination. Related Articles | Metrics

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Risk factors and drug sensitivity characteristics of pathogenic microorganisms in children with communityacquired pneumonia 2020, 12 (1):  33-37.  doi: 10.3969/j.issn.1674-3865.2020.01.009 Abstract ( 216 )   PDF (595KB) ( 50 )   Save Objective To investigate the risk factors and the characteristics of drug sensitivity of pathogenic microorganisms in children with communityacquired pneumonia Methods Totally 240 children with communityacquired pneumonia were selected as the study group and 240 children who underwent health examination in the same period were selected as the control group Firstly,according to univariate analysis,risk factors(P<0.05) were included in the multivariate regression analysis At the same time,bacterial culture and drug sensitivity tests were carried out on sputum or saliva of children in the study group to analyze the distribution and drug sensitivity of pathogenic microorganisms Results Age(>3 years old and <6 years old),premature delivery,breastfeeding <6 months,passive smoking,congenital diseases and air pollution were risk factors for communityacquired pneumonia in children;breastfeeding within 3 months,reasonable diet,indoor decoration(>5 years) were protective factors In the study group,52 pathogenic bacteria were isolated from sputum of 240 children with pneumonia,and 29 were Grampositive bacteria(55.8%),mainly Streptococcus pneumoniae(12,23.1%) and Staphylococcus aureus(9,17.3%) The resistance rates to clindamycin,erythromycin and compound neomycin were 95.2%(20/21),90.5%(19/21),and 85.7%(18/21),respectively They were more sensitive to moxifloxacin,vancomycin and cephalosporins There were 23 Gramnegative bacteria(44.2%),mainly Haemophilus influenzae(21.2%) The resistance rates to compound sulfonamide,cefaclor and ampicillin were 72.7%(8/11),63.6%(7/11) and 545%(6/11),respectively They were sensitive to cefotaxime,ofloxacin and chloramphenicol Conclusion Risk factors of pneumonia in children are related to age (>3,<6 years old),premature delivery,breastfeeding <6 months,passive smoking,congenital diseases and air pollution;protective factors are related to breastfeeding within 3 months,reasonable diet and indoor decoration(>5 years);Streptococcus pneumoniae,Staphylococcus aureus and Haemophilus influenzae are the main bacteria for infections;floxacins and cephalosporins are more sensitive. Related Articles | Metrics

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Professor Jia Liujin′s clinical experience in treating spasmodic cough of pertussis 2020, 12 (1):  37-40.  doi: 10.3969/j.issn.1674-3865.2020.01.010 Abstract ( 135 )   PDF (666KB) ( 29 )   Save As a famous Chinese physician and a tutor in the work of inheriting academic experience of prestigious Chinese physicians in China,Professor Jia Liujin thinks that the diagnosis and treatment of pertussisa refractory childhood diseaseshould be based on the combination of Chinese syndrome differentiation with the western disease differentiation,exploring the source in literatures and performing treatment by staging The treatment should focus on spasmodic cough,and the cause should be made clear by studying symptoms to confirm the disease He believes that the spasmodic cough is mostly heat and excess syndrome,and the pathogenesis is that the phlegm blocks the air tract,causing the fire to rise Therefore,it is necessary to observe the treatment principle of “controlling the fire before removing phlegm and control fire to clear Qi” Maxing Shigan decoction combined with Qingqi Huatan decoction in modification is used in the treatment in order to achieve the effect of “clearing fire to smooth Qi and removing phlegm to relieve cough”. Related Articles | Metrics

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Effect of atomization inhalation of ribavirin in the treatment of infantile hepangina and its effect on serum immunoglobulin level 2020, 12 (1):  41-43.  doi: 10.3969/j.issn.1674-3865.2020.01.011 Abstract ( 286 )   PDF (402KB) ( 17 )   Save Objective To observe the effect of atomization inhalation of ribavirin in the treatment of infantile herpangina and its effect on serum immunoglobulin level. Methods Totally 116 children diagnosed with herpangina from December 2017 to February 2019 in pediatrics department of our hospital were selected and divided into control group and observation group according to the random number table,with 58 cases each.Both groups were treated with conventional symptomatic therapy,and the observation group was treated with atomization inhalation of ribavirin on the basis of this,with a course of treatment of 5d in both groups.The therapeutic effect was observed and the serum immunoglobulin levels were compared and analyzed. Results The time of recovery of body temperature,disappearance of herpes and disappearance of sore throat in the observation group was shorter than that in the control group(P<0.05).The serum IgA,IgG and IgM in the observation group were increased and were higher than those in the control group(P<0.05).The total effective rate in the observation group was 9138%(53/58),which was higher than that in the control group(77.59%,45/58)(P<005). Conclusion The atomization inhalation of ribavirin can enhance the immune function of children with herpangina.The effect is good and it is worthy of clinical application. Related Articles | Metrics

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Clinical observation of the effect of Shenyan Zhixue decoction on children with HenochSchonlein purpura nephritis of isolated hematuriatype 2020, 12 (1):  44-48.  doi: 10.3969/j.issn.1674-3865.2020.01.012 Abstract ( 144 )   PDF (582KB) ( 20 )   Save Objective To observe the clinical effect of TCM master ZHANG Qi′s proven prescriptionShenyan Zhixue decoctionon the children with HenochSchonlein purpura nephritis of isolated hematuriatype. Methods A total of 104 patients with HenochSchonlein purpura nephritis of isolated hematuriatype were divided into test group and control group,with 52 patients in each group.The test group took Shenyan Zhixue decoction orally,while the control group took hematuresis capsule orally.Both groups were treated for three months as a course.The RBC count in routine urine and TCM syndromes were observed at 2 weeks,1 month,2 months and 3 months after taking medicine. Results There were 4 cases of dropping in the test group and 10 cases in the control group.After 2 weeks,1 month,2 months and 3 months,the total effective rate in the test group (73.0%,82.%,86.0% and 89.6%) was significantly higher than that in the control group(59.6%,600%,61.7% and 64.3%) (P<0.05).The RBC count in urine and the scores of TCM syndrome such as feverish palms and soles and night sweating in the two groups were significantly lower than those before treatment,and in the test group they were significantly lower than in the control group,the difference being statistically significant (P<0.05). Conclusion Shenyan Zhixue decoction can reduce the RBC count in urine of children with HenochSchonlein purpura nephritis of isolated hematuriatype.The effect is significant and there isn′t obvious adverse drug reactions. Related Articles | Metrics

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Therapeutic effect of rehabilitation training at home by parents on children with high risk of cerebral palsy 2020, 12 (1):  48-50.  doi: 10.3969/j.issn.1674-3865.2020.01.013 Abstract ( 205 )   PDF (390KB) ( 31 )   Save Objective To observe the therapeutic effect of family training on children with high risk of cerebral palsy (CP) Methods A total of 60 children with high risk of CP were treated in our rehabilitation center from Jan.2016 to Jan.2018,and they were randomly divided into two groups:observation group (30) and control group (30) For the observation group,Peabody family training program was given to the children in addition to conventional treatment The therapeutic effect was compared after 3 months of treatment Results After treatment the gross motor quotient (GMQ) of the observation group was 76.93±2.32,which was higher than that of the control group (72.60±2.24),and there was statistical difference (P<0.05) The comprehensive development effect in the observation group was higher than that in control group (P<0.05) Conclusion The children have faster progress in treatment if their parents can perform family training It′s good not only for gross motor ability but also for early development of cognition of children Therefore,the parents should take part in the early rehabilitation training in a proper way Related Articles | Metrics

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Clinical effect of Miya Taiji cupping on children with communityacquired pneumonia 2020, 12 (1):  51-54.  doi: 10.3969/j.issn.1674-3865.2020.01.014 Abstract ( 670 )   PDF (556KB) ( 11 )   Save Objective To observe the clinical effect of Miya Taiji cupping on children with communityacquired pneumonia Methods A total of 60 children with pneumonia admitted to our hospital from December 2018 to April 2019 were randomly divided into control group and observation group,with 30 cases in each group The control group was treated with western medicine,and the observation group was treated with the western medicine for the control group plus the auxiliary treatment of the Miya Taiji cupping,once a day,5-7 days as a course of treatment After treatment,the total effective rate,symptoms and signs of the two groups were compared Results The score of main symptoms in the observation group was significantly lower than that in the control group (P<0.05) The total effective rate of the observation group was higher than that of the control group (P<0.05) The time of fever,cough and rale disappearing and hospitalization time in the observation group were shorter than those in the control group (P<0.05) Conclusion The treatment for communityacquired pneumonia in children with Miya Taiji cupping can improve the curative effect,shorten the clinical symptoms and signs of children,and shorten the time of antibiotics use,which is worth popularizing Related Articles | Metrics

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Effects of exercise rehabilitation training on lower limb muscle strength and balance function in children with handfootmouth disease complicated with acute flaccid paralysis 2020, 12 (1):  54-57.  doi: 10.3969/j.issn.1674-3865.2020.01.015 Abstract ( 133 )   PDF (537KB) ( 36 )   Save Objective To analyze the effect of exercise rehabilitation training on children with handfootmouth disease complicated with acute flaccid paralysis,and to explore its effects on lower limb muscle strength and balance function Methods A total of 109 children with handfootmouth disease and acute flaccid paralysis were enrolled in our hospital The patients were divided into two groups according to the time of admission Among them,54 patients in the control group were routinely monitored and treated,being regularly turned over and massaged In the rehabilitation group,55 patients were given exercise rehabilitation training on this basis At the end of treatment,the muscle strength and balance function of the lower limbs of the two groups were compared Results After treatment,the proportion of patients whose lower extremity gluteus maximus,tibialis anterior and gastrocnemius muscles were grade 4 and above was higher in observation group than in control group(P<0.05) The lower limb FuglMeyer exercise scale(FMA) score and the Berg balance scale(BBS) score were higher after treatment,with the observation group being higher than the control group(P<0.05) The total effective rate of the observation group was 92.73%(51/55),which was higher than that of the control group（77.78%，42/54）(P<0.05) Conclusion Exercise rehabilitation training can improve the lower limb muscle strength of children with handfootmouth disease and acute flaccid paralysis,and improve the lower limb movement and balance ability Related Articles | Metrics

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Effects of reading therapy on children with congenital heart disease 2020, 12 (1):  58-61.  doi: 10.3969/j.issn.1674-3865.2020.01.016 Abstract ( 151 )   PDF (507KB) ( 59 )   Save Objective To explore effects of reading therapy on children with congenital heart disease (CHD). Methods Ninety CHD children treated in the hospital from November 2017 to December 2018 were enrolled.They were randomly divided into observation group and control group,45 cases in each group.Both groups were given routine oral education and disease nursing intervention.Besides,observation group was given Reading Therapy Reader for Hospitalized Children for reading therapy intervention.The perioperative heart rate,surgical cooperation,postoperative anxiety status and postoperative pain status were compared between the two groups. Results There was no significant difference in heart rate during sleep time at night or after anesthesia between the two groups (P>0.05).The heart rate in observation group was lower than that in control group when leaving ward and at anesthesia induction time (P<0.05).The anesthesia induction resistance score and emergence agitation score in observation group were lower than those in control group (P<0.05).At 18d after surgery,anxiety score in observation group was lower than that in control group (P<0.05).There was no statistical difference in the 1d,7d or 8d pain behavior score between the two groups after surgery (P>0.05);however,the 26d score was lower in observation group,and there was statistical difference(P<0.05). Conclusion Reading therapy can effectively reduce perioperative anxiety status of CHD children,strengthen their perioperative coordination degree,and alleviate postoperative pain Related Articles | Metrics

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Study on diffusion tensor imaging of corpus callosum in preschool children with febrile convulsion 2020, 12 (1):  62-65.  doi: 10.3969/j.issn.1674-3865.2020.01.017 Abstract ( 192 )   PDF (642KB) ( 43 )   Save Objective To detect and analyze the parts of corpus callosum in preschool children with febrile convulsion by diffusion tensor imaging (DTI),to observe the microscopic changes of corpus callosum,and to analyze the relationship between DTI and those changes Methods A total of 180 children received DTI examination in our hospital from June 2013 to January 2019:90 children with febrile convulsion were included in observation group and 90 with headache and without positive signs of nervous infection were in the control group The children in both groups underwent DTI examination The interested area was set respectively at every part of corpus callosum,and the FA and ADC values were determined,which were combined with clinical characteristics to make correlation analysis Results The FA value of all parts of corpus callosum was significantly decreased in observation group compared with that in control group,while ADC value was significantly increased;the FA value in the anterior 1/3 and the anterior part and the compression part in observation group was lower than that in control group;the ADC value in the anterior 1/3 and the compression part in observation group was higher than that in control group;the difference was statistically significant (P<0.05) Conclusion DTI is more sensitive than conventional MRI in the diagnosis of preschool children with febrile convulsion and it can serve as a sensitive index in the detection and disease evaluation of febrile convulsion Related Articles | Metrics

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Experience of Professor Peng Yu in treating infantile eczema 2020, 12 (1):  65-68.  doi: 10.3969/j.issn.1674-3865.2020.01.018 Abstract ( 208 )   PDF (626KB) ( 94 )   Save Professor Peng Yu′s clinical experience in the treatment of infantile eczema are summarized from the aspects of causes and pathogenesis,key points in syndrome differentiation,treatment principles and treatment methods Prof Peng believes that the itching,redness and seepage of the eczema can tell us the wind being internal or external,the poison and heat and the severity of dampness The length of disease course and the features of rash can show whether it′s deficiency or excess The changes in rash color during the treatment can indicate the prognosis Prof Peng Yu proposes that the defense and Qi should be regulated at the same time and the internal therapy and external therapy should be given at the same time in the treatment of infantile eczema,and medication should take spleen and stomach into account,which provides a new way of diagnosis and treatment of infantile eczema Related Articles | Metrics

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Clinical evaluation value of measurement parameters of tidal breathing pulmonary function in children with asthma and their relationship with clinical symptoms scores 2020, 12 (1):  69-72.  doi: 10.3969/j.issn.1674-3865.2020.01.019 Abstract ( 178 )   PDF (429KB) ( 54 )   Save Objective To investigate the clinical evaluation value of measurement parameters of tidal breathing pulmonary function in children with asthma and their relationship with clinical symptoms scores. Methods A total of 122 children with asthma who were treated in our hospital from January 2017 to January 2019 were enrolled in observation group.Another 86 healthy children who underwent physical examination at the same time were selected as control group.The two groups were given the same measurement of tidal breathing pulmonary function.The changes of pulmonary function indexes were compared between the two groups,and the clinical symptoms scores were recorded in observation group.The correlation between pulmonary function indexes and clinical symptoms scores was analyzed among the children with asthma. Results Among the 122 children with asthma,there were 31 cases of mild asthma,76 cases of moderate asthma and 15 cases of severe asthma.There were statistically significant differences in the TPTEF/TE,VT/kg,Rr,Ti/Te,VPEF/VE,PEF,TEF25%,TEF50% and TEF75% among the children with mild asthma,children with moderate asthma,children with severe asthma and healthy control group (all P<0.05).The TPTEF/TE and VPEF/VE in children with asthma were negatively correlated with clinical symptoms scores (P<0.05). Conclusion The measurement parameters of pulmonary function in children with asthma have a certain correlation with the severity of clinical symptoms,which can be used as one of the indicators to assess the severity of the disease. Related Articles | Metrics

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Effects of terbutaline on pulmonary function and inflammatory factors in children with mycoplasma pneumonia 2020, 12 (1):  72-74.  doi: 10.3969/j.issn.1674-3865.2020.01.020 Abstract ( 182 )   PDF (394KB) ( 38 )   Save Objective To investigate the effect of terbutaline on pulmonary function and inflammatory factors in children with mycoplasma pneumonia. Methods Eighty children with mycoplasma pneumonia were selected from our hospital who were treated from January 2018 to March 2019.They were randomly divided into control group and experimental group,40 cases each.The control group was given azithromycin sequential treatment,and on this basis,the patients of experimental group were given terbutaline treatment.The lung function and inflammatory factors were compared between the two groups. Results FEV1,PEF and FEV1/FVC of the experimental group were higher than those of the control group,while eosinophils,IL-2 and IL-4 were lower than those of the control group(P<0.05). Conclusion the therapeutic effect of terbutaline on children with mycoplasma pneumonia is definite,which can improve lung function and reduce the level of inflammatory factors. Related Articles | Metrics

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Effect of β-human chorionic gonadotropin level in maternal blood on pregnancy outcome in the first trimester 2020, 12 (1):  75-78.  doi: 10.3969/j.issn.1674-3865.2020.01.021 Abstract ( 164 )   PDF (367KB) ( 60 )   Save Objective To evaluate the association between abnormal levels of maternal serum β-human chorionic gonadotropin(hCG) in the first trimester and adverse pregnancy outcome. Methods Maternal serum concentration of β-human chorionic gonadotropin was measured in pregnant women from 11 to 13 weeks 6 days of gestation by timeresolved immunofluorometric assay.The association between the abnormal level of serum β-hCG in the first and second trimester and the pregnancy outcome was analyzed. Results Among all the adverse pregnancy outcomes,the women with GDM,preterm,low birth weight or fetal growth restriction had lower β-hCG levels than those with normal outcome.In the 454 pregnant women whose β-hCG level was less than the fifth percentile of normal outcome women,the incidence of pregnancy hypertension,fetal growth restriction,spontaneous abortion and low birth weight was significantly higher.What′s more,the incidence of adverse outcome also significantly increased when β-hCG level elevated both in first and second trimester. Conclusion There is association between increased frequency of adverse outcomes,such as GDM,preterm,low birth weight and fetal growth restriction,and low maternal serum βhCG levels in the first trimester. Related Articles | Metrics

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Relationship between the effect of vagus nerve stimulation and tryptophan metabolism in children with epilepsy 2020, 12 (1):  79-83.  doi: 10.3969/j.issn.1674-3865.2020.01.022 Abstract ( 139 )   PDF (548KB) ( 55 )   Save Objective To evaluate the effect of vagal nerve stimulation（VNS） on tryptophan metabolite in plasma,and investigate whether the antiepileptic effectiveness is correlated with changes in tryptophan metabolism Methods Sixty children with intractable epilepsy were included in a randomized,doubleblind study,and were divided into highoutput stimulation group and lowoutput group,30 cases in each group After a baseline period of 12 weeks,all children underwent implantation of a vagus nerve stimulator and entered a double blind activecontrolled phase of 20 weeks Subsequently,all children received highoutput stimulation for another 19 weeks (addon phase) Tryptophan metabolites were assessed in plasma by liquid chromatographytandem mass spectrometry (LC-MS/MS) and analysed in different study stages Seizure frequency was recorded using seizure diaries Mood was assessed using Profile of Mood States(POMS) questionnaires Results Regarding tryptophan metabolites in plasma,anthranilic acid(AA) levels were significantly higher at the end of the addon phase compared with baseline(P=0002),and were correlated significantly with improvement of mood(r=0.37,P=0.042） and seizure frequency reduction(r=0.35,P<0.01) No significant differences were found between high and lowoutput groups regarding seizure frequency Conclusion Vagus nerve stimulation may induces a consistent increase in AA,a neuroprotective and anticonvulsant tryptophan metabolite Moreover,increased AA levels are probably associated with improvement in mood and reduction of seizure frequency Related Articles | Metrics

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Effects of auditory integration training combined with Jin San Zhen on language disorders impairment and mental development in children with autism 2020, 12 (1):  83-85.  doi: 10.3969/j.issn.1674-3865.2020.01.023 Abstract ( 208 )   PDF (365KB) ( 52 )   Save Objective To explore the effects of auditory integration training combined with Jin San Zhen on language disorders and mental development in children with autism Methods Ninety children with autism who were treated in our hospital from February 2017 to March 2019 were selected as the research subjects and were randomly divided into control group and observation group with 45 cases each The control group was treated with acupuncture by Jin San Zhen,and the observation group was treated by auditory integration training combined with Jin San Zhen Results After 6 months of treatment,the incidence of language disorders in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05) After 6 months of treatment,the IQ scores of the two groups of children were increased,and the IQ score of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05) Conclusion Auditory integration training combined with Jin San Zhen has a significant effect on children with autism,which helps to improve children′s language disorders and their intellectual development Related Articles | Metrics

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Effect analysis of gamma globulin in adjuvant therapy for children with primary immune thrombocytopenia 2020, 12 (1):  86-88.  doi: 10.3969/j.issn.1674-3865.2020.01.024 Abstract ( 222 )   PDF (352KB) ( 30 )   Save Objective To study the effect of gamma globulin in adjuvant treatment of primary immune thrombocytopenia in children Methods Totally 72 children with primary immune thrombocytopenia treated in the department of hematology of our hospital from March 2017 to April 2018 were randomly divided into control group and observation group,36 cases each The control group received conventional hormone therapy,while the observation group received gamma globulin therapy on this basis The clinical treatment effect,platelet recovery time,bleeding cessation time,incidence of adverse reactions and recurrence rate of the two groups were compared Results The clinical effect of the observation group was significantly better than that of the control group,the difference being statistically significant (P<0.05) After treatment,the platelet recovery time and bleeding cessation time in the observation group were significantly shorter than those in the control group,with statistically significant differences(P<0.05) The incidence of adverse reactions in the observation group was 8.33%(3/36),lower than that in the control group(27.78%，10/36),and the difference was statistically significant(P<0.05) The 5month followup showed that the recurrence rate in the observation group was 2.78%(1/36),lower than that in the control group (16.67%，6/36),with no statistically significant difference(P>0.05) Conclusion Gamma globulin in adjuvant therapy for primary immune thrombocytopenia in children can significantly shorten the time of platelet recovery and bleeding cessation in children,with good clinical effect and low incidence of adverse reactions Related Articles | Metrics

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Study on factors influencing BMI and its relationship with birth weight in schoolage children 2020, 12 (1):  89-93.  doi: 10.3969/j.issn.1674-3865.2020.01.025 Abstract ( 147 )   PDF (519KB) ( 61 )   Save Objective To understand the incidence of overweight and obesity among schoolage children in Anyang City, Henan Province, the influencing factors of BMI and its relationship with birth weight, and provide a scientific basis for ensuring and promoting children's healthy growth. Methods In this study, a stratified cluster random sampling method was used. In March 2019, students in Anyang City, Henan Province, were selected as subjects, and physical examinations were carried out. At the same time, the parents or guardians of the subjects filled out relevant questionnaires to obtain the information on daily behavioral habits, such as general demographic characteristics, eating habits, family history, and sports and sleep data. The variance analysis or Chisquare test was used to compare the general conditions of children with different birth weights. Multivariate logistic regression analysis was used to analyze the influencing factors of BMI in schoolage children. Results A total of 548 children were enrolled in the study, and at the same time questionnaires survey and physical examinations were carried out. There were 308 boys and 240 girls, with an average age of (8.53±1.77) years, mean BMI (20.58±5.09) kg/m2, and average birth weight (3 802.53 ±117.77) g. The incidence of low birth weight was 6.0%, and the incidence of macrosomia was 7.7%. The overweight detection rate was 13.7%, and the obesity detection rate was 5.5%. After stratification according to different birth weights, there were differences in breastfeeding, premature birth, father BMI, maternal BMI, and child height in low, normal, and high birth weight (P<0.05). In low and high birth weight infants, the detection rates of overweight obesity were 15.2%, 0.0%, 19.0% and 9.5%, respectively. The incidence of overweight and obesity in high birth weight infants was higher than that in normal birth weight children(P=0.001). Multivariate logistic regression analysis showed that the risk factors for childhood obesity were: high birth weight(OR=1.97, 95%CI=1.23-3.05), premature delivery(OR=1.56,95%CI=1.16-2.13), father BMI exceeding the standard(OR=1.78, 95%CI=1.09-2.58), mother BMI exceeding(OR=2.13,95%CI=1.63-3.40), children's big hip circumference(OR=1.16, 95%CI=1.03-1.87); lower obesity occurred in breastfeeding(OR=0.66, 95%CI=0.23-0.87), height of children being higher(OR=0.84,95%CI=0.51-0.96), and father's height being higher(OR=0.72, 95%CI=0.43-0.90). Conclusion Many factors affect the occurrence of childhood obesity. Parents maintaining proper weight before and during pregnancy and breastfeeding can reduce the incidence of childhood obesity. High birth weight infants tend to develop obesity in childhood, so prevention of obesity should start during prepregnancy and embryonic period. Related Articles | Metrics