Table of Content

25 June 2021, Volume 13 Issue 3 Previous Issue    Next Issue

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Meta-analysis of the treatment for Kawasaki disease with Weiqi and Yingxue differentiation YANG Xiangna, DENG Jian, YE Qina 2021, 13 (3):  185.  Abstract ( 168 )   PDF (1394KB) ( 20 )   Save Objective: To conduct a Meta-analysis of the efficacy of Weiqi Yingxue differentiation in the treatment of Kawasaki disease. Methods: Through computer and manual retrieval of keywords,search related literatures by logging into major database websites at home and abroad,and collect the literatures of randomized controlled clinical studies on the treatment of Kawasaki disease with Weiqi Yingxue differentiation published at home and abroad from 2005 to 2019.Through quality evaluation,supplementary and re-screening were conducted according to the inclusion criteria of literature.Intervention measures were Weiqi Yingxue differentiation treatment and conventional western medicine treatment.RevMan 5-3 software was used to make a meta-analysis of the included literatures that met the standards.It mainly included significantly effective rate,effective rate,heterogeneity and publication bias. Results: A total of 195 relevant literatures were retrieved,and a total of 701 children with Kawasaki disease in 10 literatures were finally included.The significant effective and effective heterogeneity were:χ2=6.09,P=0.73;χ2=2.61,P=0.98.The results showed that there was no heterogeneity.When using Weiqi Yingxue differentiation combined with gamma globulin and pure gamma globulin to treat Kawasaki disease,the significant effective rate combined with OR=1.97,95% CI (1.44,2.68),overall effect test Z=4.29 (P<0.000 1).The effective rate was combined with OR=3.92,95% CI (2.24,6.86),and the overall effect test Z=4.77 (P<0.000 01).The difference was statistically significant.Meta-analysis showed that the total significantly effective rate and total effective rate of Weiqi Yingxue differentiation in the treatment of Kawasaki disease were significantly better than those of western medicine alone (P<0.05). Conclusion: The total significantly effective rate and total effective rate of Weiqi Yingxue differentiation combined with gamma globulin in the treatment of Kawasaki disease are significantly higher than those of gamma globulin alone,which has certain advantages in improving the clinical efficacy in patients and reference significance in guiding clinical medication,so it is worthy of clinical promotion and application. Related Articles | Metrics

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Exploration of the clinical efficacy of 10 kinds of Chinese patent medicines in adjuvant treatment of Mycoplasma pneumoniae pneumonia in children ZHONG Runfeng, WU Zhenqi, HOU Hongbin, REN Yuanyuan, WANG Xuefei 2021, 13 (3):  191.  Abstract ( 109 )   PDF (1233KB) ( 23 )   Save Objective: To evaluate the efficacy of 10 Chinese patent medicines in adjuvant treatment of Mycoplasma pneumoniae pneumonia (MPP) in children through a network meta-analysis system. Methods: Search the CNKI,VIP,CBM,Wan Fang Date,Pubmed,Cochrane Library databases,the search time being from the establishment of the database to September 2020;the literatures on clinical trials of Chinese patent medicine combined with azithromycin in the treatment of children with MPP was collected.Two reviewers screened the literatures,extracted data,and evaluated the quality of the literatures independently.The clinical effectiveness was used as the outcome index.Revman 5.4 and Stata 14.0 softwares were used to conduct network meta-analysis. Results: A total of 48 literatures involving 4 895 children with MPP were included,concerning 10 Chinese patent medicines.The network meta-analysis showed:The clinical effectiveness of the combination of Huanglian Granules/Oral Liquid,Xiao′er Chiqiao Qingre Granules,Xiaoer Feike Granules,Xiaoer Feire Kechuan Oral Liquid,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Tuire Granules,Jinzhen Oral Liquid,Magan Granules and Podilan Antipyretic Oral Liquid with azithromycin in the treatment of children′s MPP was better than that of azithromycin alone.The other drugs showed no statistical difference when compared between each two.According to the ranking results of the surace under cumulative ranking area (SUCRA) value of different oral Chinese patent medicines,the top 4 medicines in terms of improving clinical efficiency were:Xiaoer Feike Granules,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Antipyretic Granules and Xiao′er Chiqiao Qingre Granules. Conclusion: Chinese patent medicine assisting azithromycin in the treatment of children with MPP can improve the clinical effectiveness,and the effects of Xiaoer Feike Granules,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Antipyretic Granules and Xiao′er Chiqiao Qingre Granules are better than other Chinese patent medicines. Related Articles | Metrics

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Research progress in external treatment with Chinese medicine for mesenteric lymphadenitis in children GUO Kun, WU Jiusi, ZHAO Hongxia, OU Yajuan 2021, 13 (3):  196.  Abstract ( 123 )   PDF (747KB) ( 58 )   Save Objective: Traditional Chinese medicine has obvious advantages in treating mesenteric lymphadenitis,and the external treatment is especially effective.This article summarizes the reports on TCM external therapy for mesenteric lymphadenitis in the past five years.It is found that acupuncture,massage,acupoint application and umbilical therapy,enema with traditional Chinese medicine,percutaneous treatment with traditional Chinese medicine on acupoints,ultrasonic induction of traditional Chinese medicine,microwave physiotherapy and other methods are more effective than conventional treatment with pure western medicine.This provides reference and methods for clinical treatment and broaden the thoughts on clinical treatment methods to a certain extent hoping to further promote the external treatment of TCM in clinical practice. Related Articles | Metrics

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Research progress in animal models of co-infection by influenza virus and Streptococcus pneumoniae at home and abroad HE Hao, WANG Xuefeng, ZHANG Xiuying, HUANG Wanyi, WANG Shuang 2021, 13 (3):  201.  Abstract ( 57 )   PDF (538KB) ( 64 )   Save Influenza virus infection is one of the most prevalent infectious diseases in the world.Influenza virus infection can induce bronchitis and pneumonia,but severe lethal pneumonia is observed when complications involve bacterial infections.Animal models play an important role in the study of co-infection with influenza virus and Streptococcus pneumoniae.Different animal models have different advantages and limitations.This article introduces commonly used animal species and determination methods of pathogens,and synthesize the choice of modeling time points for different research purposes and the determination methods of models.The current research progress of co-infection models at home and abroad is summarized,with a view to provide reference for basic and applied research on co-infection. Related Articles | Metrics

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Influence of non-pathological factors on artery blood gas analysis value of neonates CHEN Zongli, LUO Keyong, JIANG Ruyong, ZHANG Pinglin, YAN Xueyu 2021, 13 (3):  205.  Abstract ( 39 )   PDF (428KB) ( 3 )   Save This paper mainly summarized the non-pathological factors that affect the results of blood gas analysis in order to help clinicians to exclude non-pathological factors and correctly judge the condition of children and provide guidance for regulating the indexes of respirators and using alkaline drugs, and lay a foundation for future research on various non-pathological factors. Through the retrieval and analysis of related documents, it was found that non-pathological factors, such as blood specimen collection, specimen storage time and temperature, anticoagulant, neonatal body temperature and air mixing, could affect the blood and gas analysis value, which should attract the attention of clinical medical staff. Related Articles | Metrics

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Research on children′s chronic cough syndrome based on association rule apriori algorithm WANG Xuefei, WU Zhenqi, REN Yuanyuan, ZHONG Runfeng 2021, 13 (3):  208.  Abstract ( 78 )   PDF (756KB) ( 4 )   Save Objective: To use the statistical association rule apriori algorithm to explore the distribution and combination laws of the disease location,disease nature and syndrome types of chronic cough in children. Methods: The literatures on children′s chronic cough in the literature databases were searched,common syndrome factors were extracted,the frequency distribution of disease location and disease nature was obtained,and the names of common syndrome factors were got through cluster analysis.The common syndrome elements and their corresponding syndrome types were counted.Through the apriori algorithm the association rules among the various syndrome elements were worked out to reflect the etiology and pathogenesis of chronic cough in children. Results: According to the statistics of the classification and combination of syndrome types,disease locations,and disease factors in the literature,a total of 145 qualified literatures on chronic cough in children were collected,and a total of 1 043 syndrome factors were recorded.Among them,the disease location syndrome factors were lung,spleen,kidney,stomach,and liver had the highest frequency.Disease syndrome elements such as phlegm,fire,qi inverse,wind,dryness and dampness had the highest frequency.Association rules:(1)Exogenous chronic cough:the location of the disease was related to the disease element:wind,dryness ==> lung (0.286).(2)Internal traumatic chronic cough:the location of the disease element was correlated:spleen ==> lung(0.808).Disease syndrome factors were correlated:wet ==> heat(0.649);disease nature was related to disease location syndrome factors:Qi deficiency ==> lung,spleen(0.863). Conclusion: Based on the physiological characteristics of children with three deficiencies and two excesses,the main diseases locations of children′s chronic cough are lung,spleen,kidney and liver;it is closely related to water metabolism,which provides a dialectical idea for the clinical differentiation of chronic cough from the perspective of dryness and dampness. Related Articles | Metrics

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Analysis of medication rules in children with pharyngitis based on data mining YUE Sicong, ZHANG Weidong, TANG Shubin 2021, 13 (3):  213.  Abstract ( 232 )   PDF (829KB) ( 7 )   Save Objective: To explore the medication data in children with pharyngitis treated by Prof. Zhang Weidong, the chief physician, and to study the characteristics of his medication and the rules of prescription. Methods: The clinical prescriptions of Prof. Zhang in the treatment of children with pharyngitis were collected. Excel and IBM SPSS 22.0 softwares were used to establish the database. A total of 700 prescriptions were analyzed by IBM SPSS Modeler 18 and Apriori algorithm of association rules, concerning the types and channel tropism of medicines, frequency in use, and the medication rules. The charts were used to describe them. Results: The top five drugs, based on the frequency in use, were Baikal Skullcap, radix scrophulariae,scorched hawthorn fruit, licorice and Forsythia suspensa. The top three types of drugs with high frequency were heat-clearing drugs, the drugs for relieving cough and reducing sputum and the drugs for tonifying deficiency. The drugs were mainly cold, warm and mild in nature, and they were mostly sweet, bitter and pungent. The top three types of channel tropism of high-frequency drugs were in turn liver meridian, lung meridian and stomach meridian. According to association rules analysis, it was concluded that radix scrophulariae, Fritillariathunbergii, scorched hawthorn fruit, Baikal Skullcap, Forsythia suspensa, Licorice and dark plum were the core drugs. Conclusion: Based on the analysis of the frequency in drug use, association and organs, it is shown that Prof. Zhang focuses on nourishing Yin, clearing heat, detoxification and resolving phlegm and blood stasis in the medication. Related Articles | Metrics

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Analysis of the prevalence and characteristics of intelligence of Yugur preschool children with ADHD in Gansu Province ZHU Yanfang, DING Yanmei, JIN Juan 2021, 13 (3):  218.  Abstract ( 49 )   PDF (554KB) ( 21 )   Save Objective: To investigate the prevalence of attentiondeficit/hyperactivity disorder (ADHD) in 4-7-year-old children of Yugur nationality in Gansu Province,and analyze the related intelligence characteristics of the children. Methods: Three public kindergartens in Sunan Yugur Autonomous County of Gansu Province were selected by using stratified cluster random sampling method.Totally 413 Yugur preschool children aged 4-7 years old were investigated by using the Conners (PSQ) parents′ symptom questionnaire and teachers′ questionnaire.In the children with positive PSQ other neurological and mental diseases were excluded.The DSM (Fifth Edition) was used as the diagnosis criteria,and the results of Wechsler primary and preschool intelligence scale (WPPSI) which was used to test children′s intelligence were analyzed. Results: A total of 413 questionnaires were sent out and 411 valid questionnaires were collected.The total prevalence of ADHD was 2.9% (12/411),and it was 3.6%(8/225) in boys and 2.2%(4/186) in girls.There was no significant difference between boys and girls (P>0.05).The intelligence test index of WPPSI of Yugur preschool children aged 4-7 years was lower than that of normal control group(P<0.01).The operation IQ in WPPSI of girls was statistically higher than that of boys(P<0.05). Conclusion: The prevalence of ADHD in Yugur preschool children in Gansu Province is significantly lower than the national average level,which may be related to national character,family situation and living environment.The intelligence level of ADHD children is lower than that of the normal,so early intervention should be carried out. Related Articles | Metrics

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Effect of stability training of core muscle group combined with crawling training on the motor and intellectual development of children with spastic cerebral palsy MIAO Yi, ZHANG Xiaodong, HOU Xiaochen 2021, 13 (3):  222.  Abstract ( 56 )   PDF (358KB) ( 28 )   Save Objective: To observe the effect of stability training of core muscle group combined with crawling training on motor and intellectual development of children with spastic cerebral palsy. Methods: Totally 95 children with spastic cerebral palsy treated in our hospital from February 2018 to October 2019 were selected and randomly divided into control group (47 cases) and observation group (48 cases). The control group was given routine crawling training, and the observation group was given stability training of core muscle group in addition to crawling training. The crawling ability and intellectual development of the two groups were observed after 3 months. Results: After the intervention, the modified Tardieu spasm scale score of the observation group was significantly lower than that of the control group, and the gross motor function scale score of the observation group was significantly higher than that of the control group(P<0.05); after the intervention, the development index score and psychomotor development index score of the observation group were significantly higher than those of the control group (P<0.05). Conclusion: Stability training of core muscle group combined with crawling training can improve the crawling ability of children with spastic cerebral palsy, activate and coordinate the movement of upper and lower limbs, enhance the ability of innervation, and promote their intellectual development. Related Articles | Metrics

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Clinical study on acupuncture and moxibustion in adjuvant treatment of children with cerebral palsy complicated with dysarthria YAN Tingqi, WANG Shuang, GUAN Lijun 2021, 13 (3):  225.  Abstract ( 58 )   PDF (398KB) ( 6 )   Save Objective: To explore the clinical effect of acupuncture and moxibustion on children with cerebral palsy complicated with dysarthria.  Methods: Totally 60 cases of cerebral palsy complicated with dysarthria were selected, who were treated in our hospital from Jan. 2018 to Apr. 2019, and they were randomly divided into two groups: the observation group(30 cases) and control group(30 cases). The control group was given conventional language training, and the observation group received acupuncture and moxibustion in addition to the conventional language training. After the course of treatment, the differences in articulation scores and the improvement in salivation were analyzed. Results: There was no statistical difference in all the items evaluated in articulation between the two groups before treatment. After treatment, the scores of all items increased, except jaw position and soft palate movement, compared with those before treatment(P<0.05). The scores in reflex, lip movement and speech comprehension were higher in the observation group were higher than those in control group, and there was statistical difference(P<0.05). After treatment, the total effective rate concerning the treatment for salivation in observation group was 76.7%（23/30）,higher than that in control group（50.0%,15/30）（P<0.05）. Conclusion: Acupuncture and moxibustion can improve the articulation function of children with cerebral palsy and dysarthria and improve salivation, which is worth clinical promoting. Related Articles | Metrics

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Relationship between the changes in blood flow of lenticulostriate artery and the degree of brain injury in neonatal hypoxic-ischemic encephalopathy ZHAO Jiabao, HUO Yaling, LIU Yang 2021, 13 (3):  228.  Abstract ( 98 )   PDF (465KB) ( 21 )   Save Objective: To study the clinical value of the changes in blood flow parameters of lenticulostriate artery in the evaluation of neonates with hypoxicischemic encephalopathy(HIE). Methods: A total of 80 children with HIE treated in our hospital from Jan. 2018 to Feb. 2020 were included as the observation group, among whom 32 were mild, 22 were moderate and 26 were severe. During the same period, 40 healthy neonates were chosen as the control group. The changes in peak systolic velocity(Vs), end-diastolic velocity(Vd) and resistance index(RI) of lenticulostriate artery at 24h, 48h and 72h after birth were determined. Results: At 24h after birth, the Vs and Vd of lenticulostriate artery in HIE children of observation group were significantly lower than those in control group, and RI was significantly increased compared with control group, the differences being statistically significant(P<0.05). There were also statistical differences in Vs, Vd and RI between mild HIE children and moderate and severe HIE children(P<0.05). There was no statistical difference in Vs, Vd or RI between moderate groups and severe group(P>0.05). At 48h and 72h after birth, the Vs, Vd and RI in mild and severe HIE children were close to normal or completely normal(P>0.05), while they were still lower in severe group than in mild, moderate and control group, and RI was continuously increasing, the differences being of statistical significance(P<0.05). Conclusion: The changes in blood flow parameters of lenticulostriate artery have significant clinical value in the evaluation of brain injury in HIE children, which can provide imaging evidence for early clinical intervention. Related Articles | Metrics

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Significance of EV71 IgG, IgM and IgA antibodies in the diagnosis of hand-foot-mouth disease LAI Fang, WEN Huanyu, LIANG Xueyan 2021, 13 (3):  231.  Abstract ( 92 )   PDF (378KB) ( 10 )   Save Objective: To explore the application value of EV71 IgG, IgM and IgA antibodies in the diagnosis of hand-foot-mouth disease. Methods :Totally 116 cases of children with hand-foot-mouth disease(HFMD) infected with EV71 who were treated in our hospital from March 2019 to March 2020 were selected, and the type of virus was detected by real-time fluorescent quantitative PCR, and the EV71 IgG, IgM and IgA antibodies were detected by immunochromatography. Results: The positive rates of EV71 IgG, IgM and IgA antibodies were 62.07%(72/116), 68.10%(79/116) and 60.34%(70/116), respectively,and the positive rate of EV71 nucleic acid test was 72.41%(84/116), the difference being not statistically significant(P>0.05).The positive rate of EV71 IgM and IgG antibody in mild children was lower than that in severe children,and the difference was statistically significant(P<0.01). Conclusion: The diagnostic ability of the detection of EV71 IgG, IgM and IgA antibodies in hand-foot-mouth disease is good; the positive rate of IgM and IgG antibody of severe EV71 is higher than that of common children, which suggests that it has clinical application value for early diagnosis and symptomatic treatment of the disease. Related Articles | Metrics

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Clinical analysis of hemophagocytic syndrome in children BIAN Shuang, LI Chenghui, GAO Hui 2021, 13 (3):  234.  Abstract ( 141 )   PDF (398KB) ( 12 )   Save Objective: To investigate the clinical features，diagnosis，individualized treatment and prognosis of hemophagocytic syndrome(HPS). Methods: A retrospective study was carried out to analyze the clinical data of 24 HPS cases treated in our hospital from Sep. 2015 to Nov. 2018. Results: The most common clinical manifestations were fever and splenomegaly.There were also central nervous involvement and acute liver failure as the first clinical manifestations of HPS.The features of laboratory data included cytopenia(29.2%)，coagulation disorder(83.3%)，high level of triglyceride(45.8%)，hepatic function damage(87.5%)，elevated lactate dehydrogenase(100%)，elevated C reactive protein(70.8%),calcium ion(25%)，reduced sodion(66.7%)，elevated ferritin(87.5%)，reduced activity of NK cells(91.75%)，and elevated level of sCD 25(100%); hemophagocytosis and histiocytes could be seen in bone marrow of 23 cases. Conclusion: HPS has diverse clinical manifestations;therefore,good results can be obtained by early identification,early diagnosis,and trying to find the primary cause in order to perform individualized treatment. Related Articles | Metrics

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Therapeutic effect and analysis of syndrome-differentiated treatment for children with Henoch-Schonlein purpuranephritis with traditional Chinese medicine ZHANG Li 2021, 13 (3):  237.  Abstract ( 180 )   PDF (543KB) ( 7 )   Save Objective: To explore the clinical effect of syndrome-differentiated treatment for children with Henoch-Schonlein purpura nephritis（HSPN） with traditional Chinese medicine. Methods: A total of 62 childrenwith HSPN admitted to our hospital from September 2017 to June 2019 were selected as the research subjects, and they were randomly divided into control group and observation group, with 31 cases in each group. The control group was treated with conventional western medicine, and the observation group received modified TCM treatment based on syndrome differentiation as well as western medicine. Patients in both groups were treated for 20 weeks continuously. The clinical efficacy and the changes in urinary protein and erythrocyte count in 24 h before and after treatment were compared between the two groups. Results: After 20 weeks of treatment, the total effective rate of the observation group was 96.8% (30/31), which was significantly higher than that of the control group(74.2%,23/31), and the difference was statistically significant(P<0.05). The 24 h urine protein quantity and urine red blood cell count in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusion: The treatment with TCM based on syndrome differentiation has significant curative effect and can prevent kidney damage, which is worthy of clinical promotion. Related Articles | Metrics

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Analysis of clinical characteristics of infectious mononucleosis in children BAO Lili, JI Chenlin, WU Ping, ZHAO Kai 2021, 13 (3):  240.  Abstract ( 182 )   PDF (388KB) ( 14 )   Save Objective: To analyze the clinical characteristics of children with infectious mononucleosis(IM) and to further guide clinical diagnosis and treatment. Methods: A total of 119 hospitalized children with IM diagnosed in our hospital from January 1, 2017 to December 31, 2019 were selected as the observation group, and 62 healthychildren were selected as the control group. Clinical and laboratory data were obtained and analyzed. Results: The results showed that 31 cases (26.05%) were IgA positive to EB virus antibody, 107 cases(89.92%) were IgM positive, and 33 cases(27.73%) were IgG positive. There were 54 patients with atypical lymphocytes ≥10%(45.37%).There were 35 cases(29.41%) complicated with IgM antibody positive.CD3+ and CD3+CD8+ were significantly higher in 83 patients with improved cellularimmune function than in the control group(P<0.01);CD3+CD4+, CD4+/CD8+, and CD19+ were significantly lower than those in the control group(P<0.05);59 cases (49.58%) were with impaired liver function. Conclusion: Positive IgM antibody in acute stage of IM is an important basis for clinical diagnosis. The dysfunction of cellular immunity and abnormal liver function caused by IM are common. The morphological changes of peripheral blood cells are obvious in the early stage of disease. Therefore, the analysis of clinical characteristicsof children with IM is helpful to guide clinicians in the early diagnosis and treatment of the disease, contributing to the early analysis of the disease condition, formulation of medication regimen and judgment of prognosis. Related Articles | Metrics

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Analysis of the results auxiliary examinations and clinical features of children with pertussis WU Shaoxia, LU Shaojing, HE Zhifu, ZHU Haiwei, MA Keze, YAO Weiquan 2021, 13 (3):  243.  Abstract ( 185 )   PDF (583KB) ( 7 )   Save Objective: To explore and analyze the clinical features and auxiliary examination results of children with pertussis. Methods: A total of 100 children with pertussis treated in our hospital from September2018 to January 2020 were chosen as research subjects, and the clinical characteristics were analyzed by descriptive method based on the information of symptoms, signs, baseline data, auxiliary examination and so on. Results: Totally 77 children were positive by PCR and 34 were positive by PT-IgG; including 6 cases of negative PCR and 17 without detection. There were 62 children under 6 months. Among the 100 children, there was statistical difference in no-vaccination between the common pertussis children and severe pertussis children（P<0.05）. There was statistical differences in spasticity, cyanosis around mouth and apnea betweencommon pertussis children and severe ones when coughing（P<0.05）,while there was no statistical difference in red face,cockcrow echo or short of breath between them(P>0.05). Auxiliary examinations showed that there was no statistical difference in the complication with choamydiae infection/pneumonia, respiratory virus infection or EB virus infection between common pertussis children and severe ones（P>0.05）. There was statistical difference in normal WBC count, WBC count>30×109/L and hypoxia betweencommon pertussis children and severe ones（P<0.05）, and there was also statistical difference in the increase in WBC count, WBC count being (15-30)×109/L,the increase in lymphocyte proportion, the increasein C-reactive protein, the increase in hypersensitive C-reactive protein, the increase in procalcitonin, the increase in transaminase, the increase in myocardial enzymes, chest imaging pneumonia,emphysema, respiratory failure and atelectasis between them（P<0.05）.There was one case of death after being transferred to another hospital, and the other childrenhad one to five months of cough after discharge. Conclusion: The children with pertussis are mostly under 6 months of age, and the disease is more likely to occur in children who are not vaccinated. The main source of infection is family members, and the clinical manifestations of spastic cough are often seen. The prognosis is quite good. Related Articles | Metrics

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Effect of ketogenic diet combined with cognitive training on cognitive function in children with cerebral palsy XU Jingli, OUYANG Qiuxing, LI Chengke, WANG Qiang, YANG Xiangzheng 2021, 13 (3):  247.  Abstract ( 70 )   PDF (378KB) ( 13 )   Save Objective: To explore the effect of ketogenic diet combined with cognitive training on cognitive function of children with cerebral palsy(CP). Methods: Totally 120 children with spastic cerebral palsy, who received rehabilitation treatment in the Social Welfare Center of Longgang from March 2020 to August 2020, were selected, and they were divided into observation group(60 cases) and control group(60 cases) randomly. Both groups acceptedconventional rehabilitation for 6 months and the observation group was additionally given cognitive training and ketogenic diet. Gesell Development Scale was used to evaluate and compare the subjects before and after treatment． Results: Before treatment, the scores of Gesell Scale of two groups had no statistical difference(P<0.05). After treatment, the scores of Gesell Scale in both groups all increased, and the observation group showed more significant increase(P<0.05). Conclusion: Ketogenic diet can improve the cognitive function in children with cerebral palsy.  Related Articles | Metrics

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New application of herbal paste in the treatment of winter diseases in summer for children with recurrent respiratorytract infection LI Haihua, WANG Fang, ZHANG Zhiguo, DONG Jingjing, ZHAO Hui 2021, 13 (3):  250.  Abstract ( 84 )   PDF (473KB) ( 21 )   Save Recurrent respiratory tract infection in children results from the deficiency of lung, spleen and kidney. The key to treatment is to strengthen the body and dispel pathogenic factors, invigorate the spleen and benefit the lung, and improve the function of the lung and spleen in children, so as to achieve the purpose of improving the children's resistance to diseases. Based on the theory and clinical practice of traditionalChinese medicine, the feasibility of treating children with recurrent respiratory tract infection by using herbal paste in summer was discussed, so as to provide a new idea and a more convenient and effective method for the diagnosis and treatment of children with recurrent respiratory tract infection, and to provide a wider range for herbal paste application. Related Articles | Metrics

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Yangyin Qingfei mixture in the treatment of cough(yin-deficiency and lung-heat syndrome) after mycoplasma infection in children:a clinical observation SONG Lichao, WANG Xuefeng, GUAN Xuefeng, ZHANG Xiuying, LIU Yue 2021, 13 (3):  253.  Abstract ( 489 )   PDF (375KB) ( 41 )   Save Objective: To observe the effect of Yangyin Qingfei mixture on cough (yin-deficiency and lung-heat syndrome) after Mycoplasma pneumoniae infection. Methods: From January 2018 to June 2020,120 children with cough after mycoplasma infection (yin-deficiency and lung-heat syndrome) in Pediatric Outpatient Department and ward of Affiliated Hospital of Liaoning Universityof Traditional Chinese Medicine were randomly divided into two groups,60 cases in the treatment group and 60 cases in the control group.The control group was treated with western medicine.The treatment group was given YangyinQingfei mixture on the basis of western medicine.Both groups were treated for 7 days continuously,and the effect was observed. Results: After treatment,the scores in cough,dry stool,feverishness in palms and soles and night sweating and the total scores were significantly lower in observation group than in control group(P<0.05).After treatment,the total effectiveness in observation group was better than that in control group(P<0.05).After treatment,the effective rate in observation group was 96.67% (58/60),which was higher than in the control group (81.67%,49/60)(P<0.05). Conclusion: Yangyin Qingfei mixture has a significant effect on cough (yin-deficiency and lung-heat syndrome) after mycoplasma infection in children. Related Articles | Metrics

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Experience in liver-based treatment for children with Tic disorder LIU Yuanyuan, GUO Yuqing, HAN Xinmin 2021, 13 (3):  256.  Abstract ( 93 )   PDF (486KB) ( 24 )   Save This paper aims to make a summary of Prof. Han Xinmin's experience in liver-based treatmentfor children with Tic disorder. The clinical manifestations of Tic disorder are various, being sometimes mild and sometimes severe, which is in accordance with the features of "wind" in traditional Chinese medicine. Prof. Han Xinmin believes that the focus of the disease is mainly in liver, so the syndrome differentiation should be based on liver, taking all five organs (heart, liver, spleen, lung and kidney) into consideration. The treatment should focus on regulating liver, while giving consideration to other four organs. Always rememberto deal with "wind" and it is recommended to have family care, both physically and psychologically. The clinical effect is significant. Related Articles | Metrics

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Experience introduction of treating postinfectious bronchiolitis obliterans by the method of eliminating phlegm, promoting blood circulation and dredging collateral CHEN Zhengguang, WAN Lisheng, LUO Hui 2021, 13 (3):  259.  Abstract ( 83 )   PDF (557KB) ( 19 )   Save Postinfectious bronchiolitis obliterans is an irreversible chronic obstructive pulmonary diseasein pediatric clinic，which is an important type of bronchiolitis obliterans in children. Currently there is no effectivetreatment for postinfectious bronchiolitis obliterans in modern medicine, which has caused serious damage to children's health. TCM treatment for this disease has significant characteristics. This paper introduces ProfessorWan Lisheng's understanding of postinfectious bronchiolitis obliterans and his clinical experience in differentiatingand treating the disease. As phlegm and blood stasis blocking collaterals runs through the disease, Professor Wan Lisheng has proposed the method of removing phlegm, promoting blood circulation and dredging collaterals on the basis of staging treatment, which has achieved great effects. Related Articles | Metrics

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Effect of comprehensive rehabilitation nursing on quality of life of premature infants HAN Xueting, LIN Niannian, JIN Xin, JIN Yan 2021, 13 (3):  262.  Abstract ( 60 )   PDF (648KB) ( 3 )   Save Objective: GMs are used to evaluate early prediction of neurodevelopmental outcomes in preterm infants,and to implement early comprehensive rehabilitation nursing intervention and continuous nursing for premature infants with abnormal evaluation results,and observe their clinical effects. Methods: The 113 preterm infants,who were admitted to the NICU ward of our hospital from October 2018 to September 2019 before the corrected gestational age of 46W and were evaluated by GMs as monotone writhing,were randomly divided into observation group (n=56) and control group (n=57).The control group received routine nursing care for premature infants,and the observation group received rehabilitation nursing interventionon the basis of routine nursing care for the control group.The above children who were assessed by GMs againas normal restless movement after the correction of gestational age of 49W were further treated with group intervention and continuous care,and were followed up at the age of 3 months,6 months and 12 months.During follow-up,the Alberta Infant Motor Scale (AIMS) and Gesell Rating Scale were used to compare the effects of interventionbetween the two groups. Results: There was no statistical difference in Alberta scores or percentiles between the two groups at 3 months and 6 months (P>0.05).There were significant differences in Alberta total scores and percentiles between the two groups at 12 months of age,with the observation group being higher (P<0.05,P=0.009);Gesell evaluation results showed that there were differences in the adaptability and social behavior between the two groups.The adaptability was higher in observation group at 12 months old(P<0.05),the social behavior score was higher in observation group at 6 months old and 12 months old,which had statistical significance(P<0.05). Conclusion: Comprehensive rehabilitation nursing intervention for high-risk premature infants has certain clinical effects on adaptability,social behavior and quality of completing action. Related Articles | Metrics

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Influence of family-centered nursing mode on the quality of life of children with leukemia undergoing chemotherapy DU Tingting 2021, 13 (3):  266.  Abstract ( 47 )   PDF (401KB) ( 8 )   Save Objective: To explore the influence of family-centered nursing mode on the quality of life of children with leukemia undergoing chemotherapy. Methods: A total of 70 children with leukemia who receivedchemotherapy in our hospital from June 2018 to December 2019 were selected as the study subjects, and the patients were divided into the control group and the observation group according to different nursing methods, 35 in each group. Routine nursing was used in the control group, and family-centered nursing was used in the observation group in addition routine nursing. SF-36 was used to evaluate the quality of life of the two groups of children, and the quality of life and family nursing satisfaction of the two groups were compared. Results: After nursing, the SF-36 score of the observation group was significantly higher than that of the control group, the difference being statistically significant(P<0.05); the nursing satisfaction rate of the family members of the observation group was 94.29%(33/35), significantly higher than that of the control group(74.29%,26/35), and the difference was statistically significant(P<0.05). Conclusion: The family-centerednursing mode can effectively improve the quality of life of children with leukemia undergoing chemotherapy, and the family members are more satisfied with nursing. Related Articles | Metrics

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Spectrum analysis of acute respiratory virus infection in children in Lanzhou city from 2017 to 2018 SHAO Lili, DONG Xinfang, DING Xia, JIAO Qiongjie, ZHANG Shimei, NI Qian 2021, 13 (3):  269.  Abstract ( 238 )   PDF (819KB) ( 9 )   Save Objective: To understand the viral pathogen composition and epidemic characteristics of children aged 0-14 year old with acute respiratory tract infection(ARTI) in Lanzhou city from 2017 to 2018, and to provide clinical basis for the diagnosis and prevention of ARTI in children. Methods: A total of 188 pharyngeal swabs of children with ARTI were collected from outpatient department, whichmeet the inclusion criteria, in Lanzhou University Second Hospital from October 2017 to September 2018. Capillary electrophoresiswas used to detect Influenza virus(IFV)A and B(IFVA, IFVB), respiratory syncytial virus(RSV)A and B(RSVA, RSVB), parainfluenza virus (PIV)1.4(PIV1.4), adenovirus(ADV), human metapneumonia virus(HMPV), human bocavirus(HBoV), rhinovirus/human enterovirus(HRV/HEV), and human coronavirus(HCoV).  Results: At least one kind of viruses was detected in 173 out of 188 cases, the overall positive rate was 92.02%. The positive rate of RVS was highest with a value of 34.0% (64/188), followed by IFV 30.9% (58/188), PIV 22.9% (43/188), ADV 19.1%（36/188）, HRV/HEV 10.6%（20/188）, HCoV 7.4%（14/188）, HBoV 3.2%（6/188）and HMPV 2.1%（4/188）. There were 44 cases(23.4%) of mixed infectionof two or more kinds of viruses. There was no significant seasonal difference in the positive rate of RSV, IFV and ADV, and the positive rate of PIV, HRV/HEV and HCoV was significantly increased. The positive rate of respiratory virus in children under 1 year old was the highest, reaching 100.0%.  Conclusion: Child ARTI in Lanzhou city from October 2017 to September 2018 are mainly caused by RSV, IFV, PIV and ADV, and should be controlled through the whole year. Virus infection is the main pathogen at early stages of child ARTI under 1 year old, and the routine use of antimicrobial agents is not appropriate. Related Articles | Metrics

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Analysis of clinical characteristics of children with orthostatic intolerance in Inner Mongolia CHANG Xin, CHEN Liqing 2021, 13 (3):  274.  Abstract ( 271 )   PDF (350KB) ( 23 )   Save Objective: To explore the clinical characteristics of children with orthostatic intolerance(OI), strengthen the understanding of OI, and improve the level of diagnosis and treatment of OI. Methods: A retrospectiveanalysis of 102 cases of orthostatic intolerance was conducted, who were treated from January 2018 to December 2019 in the Maternal and Child Health Hospital of Inner Mongolia Autonomous Region to explore the clinical characteristics of orthostatic intolerance. Among them, 62 children with orthostatic intolerance confirmed by HUTT were included as the observation group, and 40 children with negative HUTT were included as the control group. Results: In 62 cases of OI, 43 cases (69.4%) were VVS, 17 cases(27.4%) were POTS and 2 cases(3.2%) were OHT. Among the 62 cases, 55 cases(88.7%) had induced factors, including 20 cases(32.2%) of longterm standing, 17 cases(27.4%) of posture change, 14 cases(22.6%) of strenuous exercise. Among the 62 cases,52 cases(83.8%) had precursory symptoms in head-up tilt test(HUTT). The common manifestations were dizziness in 33 cases(53.2%), chest tightness in 24 cases(38.7%), palpitation in 23 cases(37.1%), and color change in 23 cases(37.1%). Arrhythmias were found in all OI children, including 55 cases(88.7%) of sinus tachycardia and 13 cases(21.0%) of sinus bradycardia. Conclusion: The main inducing factors of OI are standing for a long time, body position change, etc., and the main precursory manifestations are dizziness, chest pain, palpitation, etc. Related Articles | Metrics