Table of Content

25 April 2018, Volume 10 Issue 2 Previous Issue    Next Issue

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Effects of glucocorticoid combined with gamma globulin on clinical symptoms and inflammatory indexes in children with pneumonia XUE Fei，WANG Shouchuan 2018, 10 (2):  93-95.  doi: 10.3969/j.issn.1674-3865.2018.02.001 Abstract ( 408 )   PDF (355KB) ( 86 )   Save objective To investigate the effect of glucocorticoid combined with gamma globulin on clinical symptoms and inflammatory markers in children with pneumonia. Methods A total of 80 cases of pediatric pneumonia in our hospital from April 2015 to April 2017 were selected, and according to the treatment methods, these patients were divided into glucocorticoid plus gamma globulin treatment group(combined treatment group,n=40) and single gamma globulin treatment group (single treatment group,n=40). Both groups were given conventional supporting treatment. The single treatment group received intravenous injection of gamma globulin. The combined treatment group received intravenous dripping of methylprednisolone injection and prednisone injection in addition to gamma globulin.The treatment lasted for 3 to 5 day as a course. Observe the clinical effect, the time for symptoms and signs to disappear, length of hospital stay and the serum level of inflammatory markers in the two groups. Results The total effective rate of combined treatment group was 92.5%(37/40), significantly higher than that of the single treatment group(70.0%, 28/40)(P<0.05).The time for fever, cough and rales to disappear and the time of shadow absorption as well as the length of hospital stay in the combined treatment group were significantly shorter than the single treatment group(P<0.05). The level of WBC count, CRP and PCT was significantly lower in the combined treatment group than in the single treatment group(P<0.05). Conclusion Compared with gamma globulin alone, glucocorticoid combined with gamma globulin can effectively improve the clinical symptoms of children with pneumonia, and reduce the level of serum inflammatory markers in children. Related Articles | Metrics

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Study on Th1/Th2-related cytokines in children with bronchiolitis SUN Tongying，CUI Zhenze，HUANG Yan，XU Chao 2018, 10 (2):  96-98.  doi: 10.3969/j.issn.1674-3865.2018.02.002 Abstract ( 354 )   PDF (362KB) ( 92 )   Save objective To study the changes of serum levels of immune cytokines in children with bronchiolitis based on Th1/Th2 balance in order to clarify the pathogenesis of bronchiolitis and provide a theoretical basis for preventing bronchiolitis from developing asthma in the future. Methods From September 2016 to February 2017, 30 children with bronchiolitis admitted to the Department of Respiratory Diseases of Children's Hospital of Dalian were treated and were chosen as observation groups. At the same time, the healthy children of the same age were selected as the control group. Use Elisa method to detect the changes of immune cytokines（IFN-γ，IL-4，IL-10，IL-13，IL-33 and IL-17） in serum of both groups. Results Compared with the control group，the level of IL-4，IL-10，IL-13，IL-33 and IL-17 in the observation group was significantly higher than that in the control group(P<0.05). Conclusion:The morbidity of bronchiolitis in children is closely related to changes of the level of cytokines，and the body is in Th1/Th2-related immune imbalance. Related Articles | Metrics

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Research progress in the etiology and pathogenesis of chronic cough in children in traditional Chinese medicine ZHU Chen,LI Xingyuan, WANG Mengran, LAO Huimin,ZHOU Peng 2018, 10 (2):  99-102.  doi: 10.3969/j.issn.1674-3865.2018.02.003 Abstract ( 405 )   PDF (597KB) ( 93 )   Save Chronic cough is a clinical common disease in children, which has brought about a series of negative impact on the children and their families. Nowadays, traditional Chinese medicine has been paid more and more attention for its significant effect. This paper reviews the statements of many TCM experts on the etiology and pathogenesis of chronic cough in children and makes a summary, and it also makes some suggestions on its clinical diagnosis and treatment based on traditional Chinese medicine. Related Articles | Metrics

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Cause of abdominal purpura in children and the advances in pathogenesis YANG Xiaolei，BAI Xue，WANG Hai 2018, 10 (2):  102-105.  doi: 10.3969/j.issn.1674-3865.2018.02.004 Abstract ( 480 )   PDF (609KB) ( 78 )   Save Based on the literatures searched both at home and abroad and the clinical working experience, this paper discussed the factors that may be closely related to the development and progression of abdominal purpura in children from three aspects: Helicobacter pylori infection, parasitic infection and food intolerance, according to the analysis of imaging and digestive function in the children with abdominal purpura. This study aims to provide a new line of thinking about the treatment program for these children and to reduce the relapse rate by avoiding contacts with these risk factors. Related Articles | Metrics

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Clinical value of procalcitonin detection in the treatment of children with bronchopneumonia and its correlation with white blood cell count and C-reactive protein ZHU Jian，ZHANG Zhiqiao，WANG Wei，LU Haidi，YU Yuhong，MAO Huiqing，WU Xudong，HE Congzhen，MEI Shilan 2018, 10 (2):  106-109.  doi: 10.3969/j.issn.1674-3865.2018.02.005 Abstract ( 456 )   PDF (468KB) ( 76 )   Save objective To investigate the clinical value of procalcitonin detection in the treatment of children with bronchopneumonia and its correlation with white blood cell count and C-reactive protein by detecting serum procalcitonin in children to guide the rational use of antibiotics. Methods A total of 180 children with bronchial pneumonia who were admitted from July 2014 to December 2016 to the Affiliated Hospital of Taicang Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine were selected and randomly divided into control group and observation group with 90 cases in each. The control group was treated routinely, and the observation group was treated with antibiotics based on procalcitonin levels. The body temperature, white blood cell count, C-reactive protein, procalcitonin, antipyretic time, hospital stay, antibiotic use time, and its use rate before and after treatment were observed. The correlation between procalcitonin and leukocyte counts and C-reactive protein was analyzed. Results There was statistical difference in body temperature, WBC count, C-reactive protein and procalcitonin in the two groups, which were all lower after treatment(P<0.05). There was no significant difference in the control of body temperature, white blood cells, C-reactive protein and procalcitonin between the treatment group and the control group(P>0.05).There was no significant difference in antipyretic time or hospital stay between the two groups(P>0.05).Antibiotic use time in the observation group was significantly shorter than that in the control group, and the antibiotic use rate was also significantly lower than that in the control group. The difference was statistically significant(P<0.05).Procalcitonin was positively correlated with leukocyte count and C-reactive protein levels, and the difference was statistically significant(P<0.05). Conclusion The detection of serum procalcitonin can more effectively guide the use of clinical antibiotics. It has important clinical value in the treatment of children with bronchopneumonia and can effectively avoid clinical abuse of antibiotics. Related Articles | Metrics

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Significance of peripheral blood lymphocyte subsets detection in the diagnosis and treatment of children with subacute necrotizing lymphadenitis ZHU Linchao，ZHANG Shufeng，WANG Xuhui，WANG Lin，WANG Xiaohui，SUN Ying 2018, 10 (2):  109-113.  doi: 10.3969/j.issn.1674-3865.2018.02.006 Abstract ( 360 )   PDF (595KB) ( 98 )   Save objective To investigate the significance of peripheral blood lymphocyte subsets detection in the diagnosis and treatment of children with subacute necrotizing lymphadenitis(CSNL). Methods The percentage of lymphocyte subsets in peripheral blood of 51 children with CSNL(CSNL group) and 30 healthy children(control group) was detected by flow cytometry(FCM), and the treatment results of CSNL were observed. Results In the 51 cases of CSNL,38 were cured,12 improved and 1 failed. Before treatment, the percentage of CD3+,CD4+ and CD19+ of lymphocyte subsets and CD4+/CD8+ of CSNL group were significantly lower than control group(P<0.05).The percentage of CD3+,CD4+ and CD19+ of lymphocyte subsets and CD4+/CD8+ of the 51 children with CSNL were significantly higher during and after treatment than before treatment(P<0.05),and the index after the treatment was higher than that during treatment(P<0.05). Conclusion The CD3+,CD4+ and CD19+ of peripheral blood lymphocyte subsets and CD4+/CD8+ can be used as important indicators for clinical diagnosis and treatment of CSNL. Related Articles | Metrics

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Analysis of intervention in food intolerance in children with tic disorder JIN Yuan，HUANG Yan，CUI Zhenze 2018, 10 (2):  114-118.  doi: 10.3969/j.issn.1674-3865.2018.02.007 Abstract ( 635 )   PDF (569KB) ( 124 )   Save objective To explore the relationship between tic disorder and food intolerance in children. Methods Children with tic disorder were chosen，who were treated in the Department of Pediatric Care Clinic and Allergy Clinic, Dalian Children's Hospital Affiliated to Dalian Medical University from April 1st 2015 to January 31st 2017 and with foodspecific IgG positive by ELISA testing. The patients were divided into two groups：intervention group and no-intervention group. All patients were followed up for 1 month, 3 months and 6 months to evaluate the effective rate of alleviating tic symptoms. Results Toally 32 cases of TD children received food intolerance test, including 24 boys and 8 girls. The average age was （6.66±2.46）years, ranging from 3 to 11 years. Of these patients, 30 cases appeared positive with positive rate being 93.4%. The positive rate of one kind of food specific IgG was 13.3%(4 cases), two kinds 53.3%(16 cases), three kinds 6.7%(2 cases), and four kinds 26.7%(8 cases). The food with highest increase of food-specific IgG was egg(87.5%), followed by milk(53.1%), flour(43.4%), tomato(25%), fish(18.8%), soybean(15.6%), corn(12.5%),rice(12.5%), crab(9.4%), shrimp(6.3%), chicken(6.3%), pork(3.1%)，beef(3.1%) and mushrooms(0). For nointervention group, the remission rate of tic symptoms in the 3 times of followup was 20%(4/20), 30%(6/20) and 40%(8/20) respectively, while the remission rate of tic symptoms was 30%(3/10), 50%(5/10) and 80%(8/10), respectively in the intervention group. Conclusion Most TD children also have food intolerance. The most common foods are egg, milk, flour and tomato. After dietary intervention, the tic disorder children with food intolerance-positive show a gradual alleviating trend with the time passing. Related Articles | Metrics

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Changes and clinical significance of the expression of P22phox of Peripheral blood mononuclear cells in children with Kawasaki disease before and after treatment DENG Bin, HUANG Yu, ZHAO Ling, PI Guanghuan 2018, 10 (2):  118-121.  doi: 10.3969/j.issn.1674-3865.2018.02.008 Abstract ( 364 )   PDF (467KB) ( 70 )   Save objective: To investigate the changes and clinical significance of the expression of P22phox mRNA of peripheral blood mononuclear cells(PBMCs) in children with Kawasaki disease(KD) before and after treatment. Methods: Totally 40 Kawasakai disease patients admitted to Pediatric Department of Northern Sichuan Medical College Affiliated Hospital from October 2015 to June 2016（15 patients with coronary artery lesions,25 patients without coronary artery lesions） who received IVIG treatment were selected in the study, and 20 age-matched healthy children undergoing elective surgery in the Pediatric Surgery of this hospital were selected as the control group. The expression of P22phox mRNA of the peripheral blood mononuclear cells(PBMCs) were measured using real-time polymerase chain reaction(RT-PCT) in the two groups before and after treatment. Results: In the treatment group, there was statistical difference in P22phox mRNA expression before and after treatment(P<0.05); the expression of P22phox mRNA had statistical difference between treatment group before treatment and the control group(P<0.01);there was no statistical difference in P22phox mRNA expression between treatment group after treatment and the control group(P>0.05). The expression of P22phox mRNA was not statistically different in the following cases: with or without coronary lesion before treatment with or without coronary lesion after treatment, with coronary lesion before or after treatment, and without coronary lesion before or after treatment(P>0.05). Conclusion:P22phox may be involved in the pathogenesis of Kawasaki disease at acute stage. Related Articles | Metrics

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Talk about the important acupoint in point pressing method of Zangfu diagram——Lanmen acupoint DU Junwei，HOU Xiugang，SUN Xiaojun，CHENG Hongyun 2018, 10 (2):  122-124.  doi: 10.3969/j.issn.1674-3865.2018.02.009 Abstract ( 2349 )   PDF (387KB) ( 135 )   Save Point pressing method of Zangfu diagram is a therapy， which can regulate the viscera Qi and restore the viscera function according to the meridian acupoints and viscera parts by using acupuncture method. Lanmen acupoint is the main point of the abdomen and Ren channel. No matter what kind of disease it is， this point must be cleared first. Lanmen acupoint is an iconic character of point pressing method of Zangfu diagram as a hinge guiding Qi downward. Related Articles | Metrics

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Application of bronchoscopy and balloon dilation under local anesthesia in the treatment of children with respiratory diseases HUANG Haibo,ZHANG Jinfeng 2018, 10 (2):  124-126.  doi: 10.3969/j.issn.1674-3865.2018.02.010 Abstract ( 304 )   PDF (379KB) ( 69 )   Save objective To investigate the effect and prognosis of bronchoscopy and balloon dilatation under local anesthesia in children with respiratory diseases. Methods The clinical data of 94 children with respiratory diseases admitted to our hospital from May 2014 to December 2016 were retrospectively analyzed. All patients underwent bronchoscopy under local anesthesia, and endoscopic bronchoscopic interventions were performed according to the diagnosis, including high-pressure balloon dilatation. Then observe the bronchoscopic results and compare the blood gas analysis, heart rate and quality of life score before and after treatment. Results The results of bronchoscopy showed that there were 67 cases of lung infection,15 cases of atelectasis,8 cases of recurrent cough and asthma,2 cases of bronchial foreign body and 2 cases of dysplasia. After treatment, the levels of heart rate and blood gas analysis were better than before treatment (P<0.05).The scores of quality of life after treatment were significantly higher than before treatment (P<0.05). Conclusion The bronchoscopy under local anesthesia can effectively determine the type of disease, which guides the selection of clinical treatment options. The bronchoscopic balloon dilatation can effectively improve the airway stenosis in children and improve their clinical symptoms, thereby improving the quality of life, which is worth clinical promotion and application. Related Articles | Metrics

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Observation of curative effect of Lianhua Qingwen granule on children with infectious mononucleosis HU Wenmiao 2018, 10 (2):  127-129.  doi: 10.3969/j.issn.1674-3865.2018.02.011 Abstract ( 545 )   PDF (368KB) ( 87 )   Save objective To observe the clinical effect of Lianhua Qingwen granule combined with ganciclovir in the treatment of infectious mononucleosis in children. Methods A total of 62 cases of infectious mononucleosis who were treated in the Third People's Hospital of Zhengzhou from March 2012 to March 2017 were selected and divided into two groups: 32 cases in the observation group and 30 cases in the control group. The observation group was treated with Lianhua Qingwen granule combined with ganciclovir, while the control group was given ganciclovir only, the course of treatment being 7 to 14 days. The clinical efficacy and relief time of clinical symptoms and signs in the two groups were observed and compared. Results The total effective rate in the observation group was 90.7%(29/32), which was significantly higher than that in the control group(70.0%,21/30), the difference being statistically significant(P<0.05). The time of the temperature returning to normal, the remission time of angina and the swelling of the neck lymph node and the retraction time of liver and spleen were significantly shorter in observation group than those in the control group, the difference being statistically significant(P<0.05). Conclusion Lianhua Qingwen granule combined with ganciclovir in the treatment of IM can significantly shorten the fever time and rapidly improve the clinical symptoms and the curative effect. Related Articles | Metrics

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Significance of FQ-PCR detection in diagnosis of cytomegalovirus infection in HCMV-IgM negative infants XIE Libo，LIU Min，WANG Min 2018, 10 (2):  129-132.  doi: 10.3969/j.issn.1674-3865.2018.02.012 Abstract ( 568 )   PDF (429KB) ( 93 )   Save objective To explore the significance of combined quantitative detection of urine and milk HCMV-DNA in the diagnosis of cytomegalovirus infection in infants with negative  human cytomegalovirus(HCMV)-IgM. Methods A total of 304 children with suspected HCMV infection treated in Yichang Central People's Hospital from Jan. 2013 to Dec. 2015 were chosen. According to the children's chief complaint, physical examination and clinical first diagnosis, these children were divided into 3 groups: hepatitis group(786 children),pneumonia group(71 children) and a third group(47 children whose chief complaint was fever and diarrhea). The results of HCMV-DNA fluorescence quantitative PCR in urine of the children and breast milk of mothers were analyzed. Results The detection rate of urine HCMV-DNA in hepatitis group and a third group was 41.94%(78/186) and 51.06%(24/47), which was significantly lower than that in breast milk(53.76%,100/186;72.34%,34/47), the difference being statistically significant(P<0.05). There was no significant difference between the urine HCMV-DNA detection rate and that of the breast milk in the pneumonia group(P>0.05). There was no significant difference in the positive rate of HCMV-DNA in urine and breast milk among the three groups(P>0.05). The urine and milk were both positive in 88 cases(28.95%), milk positive in 174 cases(57.24%), urine positive in 141 cases(46.38%). Conclusion Breast milk is an important source of HCMV infection in infants. Under the condition of negative HCMV-IgM antibody, combined detection of HCMV-DNA in urine and milk can increase the positive rate of detection and avoid missed detection. Related Articles | Metrics

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Assistance of Xiyanping injection in improving immunological function of children with mycoplasma pneumonia SUN Honghua 2018, 10 (2):  133-136.  doi: 10.3969/j.issn.1674-3865.2018.02.013 Abstract ( 521 )   PDF (396KB) ( 100 )   Save objective To investigate the effects of combined treatment with azithromycin and Xiyanping injection on immunological function of children with mycoplasma pneumonia. Methods Sixty children with mycoplasma pneumonia were included and equally randomized into treatment group and control group(30 in each group). Children in the control group received intravenous administration of azithromycin, and those in the treatment group received intravenous administration of azithromycin combined with Xiyanping injection. The treatment lasted for 2 courses, with 7 days in one course. The treatment efficacy was observed. The CD4+ and CD8+ levels as well as IgA, IgG and IgM levels were also observed. Results The total effective rate in the treatment group was significantly higher than that in the control group(90% vs 67%, P<0.05). Serum CD4+ level and the ratio of CD4+/CD8+ were significantly increased, while serum CD8+ level was significantly decreased in both groups after treatment compared with before treatment (P<0.05). Serum CD4+ level and the ratio of CD4+/CD8+ were significantly increased, while serum CD8+ level was significantly decreased in the treatment group compared with the control group(P<0.05). After treatment, serum levels of IgM and IgA were significantly decreased, while the serum level of IgG was significantly increased in both groups (P<0.05). Serum levels of IgM, IgA and IgG were significantly decreased in the treatment group compared with the control group(P<0.05). Conclusion Xiyanping injection can assist azithromycin in improving immunological function of children with mycoplasma pneumonia, thereby enhancing the treatment efficacy. Related Articles | Metrics

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The value of sterile pyuria in predicting intravenous immunoglobulin unresponsive Kawasaki disease and the coronary artery abnormalities during acute phase LIU Heng, CUI Yuxia, YANG Zhenzhong 2018, 10 (2):  136-139.  doi: 10.3969/j.issn.1674-3865.2018.02.014 Abstract ( 638 )   PDF (386KB) ( 98 )   Save objective: To summarize the characteristics of Kawasaki disease(KD) patients with sterile pyuria and to investigate its value in predicting intravenous immunoglobulin(IVIG) unresponsive KD and coronary artery abnormalities(CAA) during acute phase. Methods: The records of 256 KD patients with adequate clinical data from February 2010 to May 2016 were retrospectively reviewed. The patients were assigned to non-sterile pyuria group（168 cases） and sterile pyuria group（88 cases）. Laboratory findings and clinical parameters were compared between the two groups. Cutoff value of urine leukocytes count for identifying IVIG-nonresponders was decided by ROC curve. Results: Sterile pyuria occurred in 88(34.4%) of the patients. The sterile pyuria group had longer duration of fever, higher average Kobayashi score(KS), higher proportion of children with a high KS(KS≥5) and were more often resistant to IVIG than the non-sterile pyuria group(P<0.05). The area under the ROC curve of urine leukocytes count was 0.699(95% CI: 0.580 to 0.798), with a sensitivity of 81.0% and a specificity of 52.2%. The best cut-off value for identifying IVIG-nonresponders was 27 leukocytes/μL. No statistical differences between the two groups in CAA occurrence were noted(P>0.05). Conclusion:Sterile pyuria is a common feature of KD. Urine leukocytes count >27/μL might be useful in predicting non-responsiveness to IVIG, but not in predicting the development of CAA in children with KD. Related Articles | Metrics

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Application of sevoflurane combined with remifentanil in the surgery for children receiving adenotosillectomy in ENT Department LIU Dongdong 2018, 10 (2):  140-142.  doi: 10.3969/j.issn.1674-3865.2018.02.015 Abstract ( 425 )   PDF (319KB) ( 109 )   Save objective To investigate the application and safety of sevoflurane combined with remifentanil in the surgery for children receiving adenotosillectomy in ENT Department. Methods Totally 120 cases of children undergoing adenotosillectomy from May 2016 to October in Department of ENT, Kaifeng Central Hospital were chosen and randomly divided into observation group and control group, 60 cases in each group; the observation group were treated with sevoflurane combined with remifentanil anesthesia, and the control group were treated with propofol with remifentanil anesthesia; the records were compared between the two groups of children concerning heart rate，systolic and diastolic blood pressure changes at different time, recovery of anesthesia, and incidence of adverse reactions. Results There was no significant difference in heart rate, systolic or diastolic blood pressure before anesthesia and 5 minutes after extubation in two groups(P>0.05). The heart rate, systolic and diastolic blood pressure were significantly higher in the observation group than in the control group 5 minutes after intubation and 5 minutes after the operation, the difference being statistically significant(P<0.05).After surgery the recovery time of spontaneous breathing and subjective consciousness and tracheal extubation time were significantly shorter in the observation group, which was statistically significant(P<0.05). No respiratory depression，arrhythmia，larygospasm or laryngeal edema were found in both groups. The incidence of adverse reactions(restlessness, crying, nausea and vomiting) in the observation group was significantly lower than that in the control group, the difference being statistically significant(P<0.05). Conclusion In the process of adenotosillectomy for children in department of ENT, the use of sevoglurane combined with remifentanil anesthesia has good effects of anesthesia, with stable hemodynamics, quick recovery and low incidence of adverse reactions, and is safer. Related Articles | Metrics

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Clinical observation and the cost-effectiveness analysis of the treatment with Pudilan Xiaoyan oral liquid for hand-foot-mouth disease in children ZHANG Junxia 2018, 10 (2):  143-146.  doi: 10.3969/j.issn.1674-3865.2018.02.016 Abstract ( 556 )   PDF (418KB) ( 67 )   Save objective Clinical effect and cost-effectiveness analysis of the treatment with Pudilan Xiaoyan oral liquid for hand-foot-mouth disease in children. Methods Sixty cases of hand-foot-mouth disease(common type) were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was given Pudilan Xiaoyan oral liquid and symptomatic treatment, while the control group was given recombinant interferon α-1b by intramuscular injection and ribavirin granules for orally taking, and symptomatic treatment was also given, 5 days as 1 course; observe the clinical efficacy, the time for symptoms and signs(including temperature, rash and oral herpes) to subsided, and the incidence rate of complications, the cost-effectiveness analysis was carried out. Results The recovery rate of treatment group and control group was 76.6%(23/30) and 50.0%(15/30), respectively, and there were statistically significant differences between the two groups(P<0.05). There was no statistically significant difference in the total effective rate(P>0.05). The treatment group had a shorter fever time than the control group, and there was a statistically significant difference between the two groups(P<0.05). Comparing the time for rash and oral herpes to subsided and the incidence of complication between the two groups, there was no statistically significant difference(P>0.05).The cost-effect ratio of the two groups was 4.56 in treatment group and 7.03 in control group, and the treatment group was better than the control group(P>0.05). Conclusion The clinical Pudilan Xiaoyan oral liquid in treating children with hand-foot-mouth disease(common type) is remarkable, economical and convenient, which is worthy of clinical application. Related Articles | Metrics

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Study on the effect of intravenous dripping of andrographolide in stabilizing body temperature of children with acute bronchial pneumonia SHAN Min, HUANG Yan，CUI Zhenze 2018, 10 (2):  146-149.  doi: 10.3969/j.issn.1674-3865.2018.02.017 Abstract ( 557 )   PDF (449KB) ( 96 )   Save objective To study the effect mechanism of andrographolide in stabilizing body temperature by observing the time of stable temperature and the changes in the level of related cytokines after the treatment. Methods A total of 40 children with acute bronchial pneumonia were included as the research subjects, who were treated in Dalian Children's Hospital from Oct. 2011 to Mar. 2012, and they were randomly divided into two groups: observation group(n=20) and control group(n=20). Both groups were given conventional treatment, and the observation group was also treated by intravenous dripping of andrographolide injection, 7 to 10 days as a course. The serum was taken before treatment and at 24h after the temperature was stable. ELISA was adopted to determine the level of PGE2，IL-1β，IL-6，IFN-γ and TNF-α. Observe the time of stabilizing temperature, and the changes in the level of PGE2，IL-1β，IL-6，IFN-γ and TNF-α in the serum before and after treatment. Results The time of stabilizing temperature in the observation group was (3.10±0.25)d, significantly shorter than that in the control group, which was (4.16±0.23)d, the difference being statistically significant(P<0.01). There was statistical difference in the level of IL-6 and IFN-γ before and after treatment(P<0.05), but there was no statistical difference in serum level of PGE2，IL-1β，IL-6 or TNF-α(P>0.05). There was statistical difference in serum level of PGE2 and IFNγ after treatment in both groups(P<0.05), but there was no statistical difference in the level of IL-1β，IL-6 or TNF-α(P>0.05). Conclusion Andrographolide can directly act on act on PGE2——an important medium in regulating temperature center, reducing the release of PGE2 and regulating the body temperature, which results in the decrease of the children's body temperature and the temperature returns to normal and stays stable. Andrographolide can decrease PGE2 released by hypothalamus by inhibiting IFN-γ and IL-6, achieving the effect of regulating and stabilizing the temperature. The effect of andrograpolide on serum concentration of IL-1β and TNF-α is not significant as far as this study is concerned. Related Articles | Metrics

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Effect of Bifid Triple Viable tablets combined with montmorillonite powder on pediatric diarrhea and its influence on children's immune function LI Wangyun，ZHAO Wenjuan，HU Qin 2018, 10 (2):  150-152.  doi: 10.3969/j.issn.1674-3865.2018.02.018 Abstract ( 511 )   PDF (303KB) ( 79 )   Save objective To explore the clinical effect of Bifid Triple Viable tablets combined with montmorillonite powder in the treatment of pediatric diarrhea and its influence on the immune function of children. Methods A total of 400 children with diarrhea admitted to the Department of Gastroenterology of Hunan Provincial Children's Hospital from February 2015 to February 2017 were selected as study subjects and were randomly divided into control group and observation group with 200 cases in each. The control group was treated with montmorillonite powder on the basis of routine treatment, and the observation group was treated with Bifid Triple Viable tablets on the basis of the treatment for control group. Take 3 days as a course of treatment, and the efficacy of the treatment and immune function of the children were compared between the two groups. Results After treatment, the total effective rate of observation group was 92.0%(184/200), significantly higher than 77.5%(155/200) in the control group, and the difference was statistically significant(P<0.05). The level of IgA and IgG in the observation group was significantly higher than that in the control group, and the level of CD4/CD8 was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusion Bifid Triple Viable tablets combined with montmorillonite powder has significant curative effect on children with diarrhea, and can improve the immune function of children. It is worthy of clinical promotion. Related Articles | Metrics

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Analysis of etiology of hospitalized children with hand-foot-mouth disease in Dalian from 2014 to 2016 WANG Yi，JING Shujun，WANG Dali，ZHENG Qi，YANG Guang，LIU Xiaomei 2018, 10 (2):  153-155.  doi: 10.3969/j.issn.1674-3865.2018.02.019 Abstract ( 482 )   PDF (296KB) ( 85 )   Save objective To analyze the pathogenic composition of hospitalized children with handfootmouth disease in Dalian from 2014 to 2016 and monitor the variety of pathogen. Methods Stool samples were collected from hospitalized children who suffered from hand-foot-mouth disease from June to September during the period of 2014-2016 to extract nucleic acid by magnetic bead column method and to detect the specific RNA nucleic acid fragments by fluorescence PCR. Results （1） The stool samples of 1 165 cases were collected, 91 cases were negative in intestinal virus test, and 1 074 cases were positive, among which 199 cases in 2014, including EV71 in 48 cases, CA16 in 39 cases and other enterovirus in 112 cases; there were 320 cases in 2015, including EV71 in 37 cases, CA16 in 57 cases and other enterovirus in 226 cases; there were 555 cases in 2016, including EV71 in 127 cases, CA16 in 193 cases and other enterovirus in 235 cases. （2）There were 30 cases complicated by viral encephalitis, 3 cases of negative intestinal virus test and 27 cases positive. Among positive cases, there were 12 cases in 2014, including EV71 in 7 cases, CA16 in 1 case, and other enterovirus in 4 cases; there were 3 cases in 2015, including EV71 in 1 case and other enterovirus in 2 cases; there were 12 cases in 2016, including EV71 in 5 cases, CA16 in 1 case and other enterovirus in 6 cases.（3）There were 12 cases complicated by viral myocarditis, including other enterovirus in 10 cases and CA16 in 2 cases. Conclusion A pathogenic change has happened in hand-foot-mouth disease in Dalian, with the high frequency of other enterovirus infection, which also contributes to the significantly increasing cases of viral encephalitis or viral myocarditis. Related Articles | Metrics

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Value of PCT, hs-CRP and WBC in the diagnosis of respiratory tract infection in children LI Zhengqiu，YANG Lihua，LIU Lanxiang，LIU Yunhua，JIN Shijie 2018, 10 (2):  156-158.  doi: 10.3969/j.issn.1674-3865.2018.02.020 Abstract ( 633 )   PDF (311KB) ( 87 )   Save objective To study the significance of joint detection of PCT, hs-CRP and WBC in the diagnosis of children with respiratory tract infection. Methods Totally 116 cases of respiratory tract infection were randomly selected from January 2015 to June 2016 in Hunan Children's Hospital, and according to the different diagnostic results, they were divided into bacterial infection group(n=52) and virus group(n=64), and select 58 cases of healthy children at  the same period as control group. Compared PCT, hs-CRP and WBC among three groups of children. Results The positive rate of PCT, hs-CRP and CRP in bacteria infection group was significantly higher than that of virus infection group and control group(P<0.05), and there was no significant difference between virus infection group and control group(P>0.05).The PCT, hs-CRP and CRP concentration of bacteria infection group was significantly higher than the other two groups(P<0.05), and there was no difference between virus infection group and control group(P>0.05). Conclusion The combined detection of PCT, hs-CRP and WBC can significantly improve the positive rate of diagnosis of children with respiratory tract infection, and has important clinical significance. Related Articles | Metrics

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Clinical observation on Yupingfeng powder combined with fluticasone propionate aerosol for cough variant asthma of pulmonosplenic-qi deficiency type in children ZHANG Xiaolin，WU Huijing，QIU Meixia，ZHAO Tengfei，LIU Kewei 2018, 10 (2):  159-162.  doi: 10.3969/j.issn.1674-3865.2018.02.021 Abstract ( 701 )   PDF (437KB) ( 73 )   Save objective To observe the clinical effect of Yupingfeng powder combined with fluticasone propionate aerosol for cough variant asthma of pulmonosplenic-qi deficiency type in children. Methods From April 2016 to February 2017, 90 cases of CVA children admitted to Baiyun District Hospital of Traditional Chinese Medicine and Huadu District Maternal and Child Health Hospital in Guangzhou were selected as the research subjects, and they were randomly divided into two groups:45 cases in the observation group and 45 in the control group. Three cases fell off in the observation group, with 42 cases included in the end; in the control group 5 cases fell off and finally 40 cases were included. The observation group was given oral Yupingfeng powder combined with fluticasone propionate aerosol and the control group was given fluticasone propionate aerosol. The two groups were treated for 12 weeks. The clinical efficacy, cough relief and disappearance time and adverse reactions of the two groups were observed. Four weeks after completion of treatment，the clinical effects of the two groups were compared by follow-up. Results After treatment, the total effective rate of the observation group(92.86%,39/42) was higher than that of the control group(77.50%,31/40), and the difference was statistically significant(P<0.05). The cough relief and disappearance time in the observation group was significantly shorter than that in the control group, and the difference was statistically significant(P<0.05). Four weeks after completion of treatment，the total effective rate of observation group(88.10%,37/42) was still higher than that of the control group(65%,26/40), and the difference was statistically significant(P<0.05), but the difference was not statistically significant(P>0.05) compared with that at the end of treatment. No obvious adverse reactions occurred during the treatment. Conclusion Yupingfeng powder granules combined with fluticasone propionate aerosols are superior to fluticasone alone in improving the symptoms of children with CVA of pulmonosplenic-qi deficiency type. Related Articles | Metrics

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Clinical study of acupoint application in treating acute diarrhea in infants and young children ZHANG Yinjiao，JIA Jinrong 2018, 10 (2):  163-166.  doi: 10.3969/j.issn.1674-3865.2018.02.022 Abstract ( 621 )   PDF (467KB) ( 108 )   Save objective To observe the clinical effect of acupoint application in treating acute diarrhea in infants and young children. Methods From September 2015 to November 2016， 110 cases of young children aged between 3 months and 3 years suffering from acute diarrhea were treated in the Second People's Hospital of Baiyun District. The children were randomly divided into control group(55 cases) and treatment group(55 cases). The control group was treated with montmorillonite powder and Bacillus subtilis duplex living bacterium particles，and symptomatic treatment and fluid therapy were given to prevent and correct dehydration and electrolyte disturbances. Feeding guidance was carried out; fluid was given orally, and intravenous fluid infusion was performed if necessary. On the basis of the treatment for the control group，the treatment group was also treated by acupoint application.  The application lasted for 4 h, once a day for 3 days. The clinical effect and the time for symptoms and signs to improve in both groups were observed. Results Compared with the control group，the time for the stool frequency and the stool character to return to normal，the time of dehydration correction，and the time of appetite returning to normal were shorter in the treatment group(P<0.05).The total effective rate of the treatment group was 92.73%，which was significantly higher than that of control group(70.91%，39/55)(P<0.05). Conclusion Acupoint application in treating acute diarrhea in infants and young children can rapidly improve clinical symptoms and shorten the course of diarrhea, achieving good clinical efficacy in the study. It is an effective way to treat acute diarrhea in infants and young children. Related Articles | Metrics

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Teachers' professional quality: the most important factor of effective teaching-analysis based on the Pediatrics of Integrated Chinese and Western Medicine LUO Yinhe，WANG Mengqing，DENG Yihui，XIE Jing，HU Yan，LI Lipeng 2018, 10 (2):  166-168.  doi: 10.3969/j.issn.1674-3865.2018.02.023 Abstract ( 505 )   PDF (400KB) ( 103 )   Save Teachers are the most important factor in effective teaching. The professional quality of teachers determines the effectiveness of teaching as well as the quality of education. On the basis of the analysis of the relationship between effective teaching and the professional quality of teachers, and on the basis of the teaching contents of Pediatrics of Integrated Traditional Chinese and Western Medicine, the practice and exploration of improving the professional quality of teachers were carried out. Related Articles | Metrics

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Intervention effect of oral rehabilitation nursing on children with cerebral palsy combined with dysphagia LIU Yonghui 2018, 10 (2):  169-171.  doi: 10.3969/j.issn.1674-3865.2018.02.024 Abstract ( 359 )   PDF (347KB) ( 111 )   Save objective To explore the intervention effect of oral rehabilitation nursing on children with cerebral palsy combined with dysphagia. Methods Totally 60 cases with cerebral palsy and dysphagia were selected from January 2016 to October in Shenyang Children's Hospital, and they were randomly divided into observation group and control group. Both groups were given routine nursing, and the observation group was also given oral rehabilitation nursing. The total clinical effective rate of the two groups after nursing and the difference in the score the swallowing barrier questionnaire(DDS) before and after the nursing were compared. Results The clinical effective rate of the observation group was 96.7%(29/30), which was significantly higher than that of the control group(73.33%,22/30), and the difference was statistically significant(P<0.05).The  DDS scores in both groups after nursing were lower than before nursing, the difference being statistically significant(P<0.05); after oral rehabilitation nursing, the DDS score of the observation group was significantly lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion Oral rehabilitation nursing can obviously improve the swallowing function of children with cerebral palsy combined with dysphagia, and improve the clinical symptoms. Related Articles | Metrics

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Clinical study on improvement of daily living ability of children with cerebral palsy by intervention of special rehabilitation nurses in family therapy support system LI Jie,ZHAO Ning 2018, 10 (2):  172-175.  doi: 10.3969/j.issn.1674-3865.2018.02.025 Abstract ( 438 )   PDF (431KB) ( 97 )   Save objective To observe the effect of the family training program directed by the national special rehabilitation nurses on the exercise ability and daily living ability of children with cerebral palsy(cerebral palsy). Methods Sixty children with cerebral palsy hospitalized in the Rehabilitation Ward of Shenyang Children's Hospital from November 1st, 2016 to January 30th, 2017 were selected as the subjects, and they were divided into the observation group and the control group according to the random table method. The control group was given routine rehabilitation training after admission, and the observation group was also treated according to the family training program of the Peabody Motor Development Scale(2nd edition) on the basis of the treatment for control group. After 6 months of treatment, the changes of daily living ability and sports development quotient in the two groups were compared. Results After 6 months' training, the difference of activities of daily living in the observation group was higher than that in the control group, the difference being significant(P<0.05). The differences in the gross motor development quotient, fine motor development quotient and total developmental quotient of the observation group were all higher than those of the control group, the difference being statistically significant(P<0.05). Conclusion Family training combined with rehabilitation therapy, which is directed by the national special rehabilitation nurses, can obviously improve the exercise ability and daily living ability of the children with cerebral palsy. Related Articles | Metrics

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Diao Benshu's diet therapy for children with pediatric anorexia JIAO Yifei，DIAO Benshu 2018, 10 (2):  175-177.  doi: 10.3969/j.issn.1674-3865.2018.02.026 Abstract ( 473 )   PDF (434KB) ( 69 )   Save Pediatric anorexia is a kind of pediatric common disease. It belongs to the disorder of spleen and stomach. Chief Diao has cured this kind of disease through years of clinical experience and put forward the theory of "wakening the spleen is better than invigorating the spleen, invigorating the spleen is better than nourishing the spleen". Chief Diao believes diet stagnation is also an important reason for pediatric anorexia. Chief Diao uses the dietary decoction of "Jianpi Kaiwei decoction" to cure the disease and asks the children to strengthen physical exercise. A satisfactory clinical effect has been achieved. Related Articles | Metrics

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Professor Shi Ji's experience in treating children with constipation based on lung theory ZHANG Bingxue，SONG Guihua，YU Suping，SUN Mengmeng 2018, 10 (2):  178-180.  doi: 10.3969/j.issn.1674-3865.2018.02.027 Abstract ( 371 )   PDF (396KB) ( 109 )   Save Constipation is a clinical disease in children. Base on the theory of "lung and large intestine are the exterior and interior", Prof. Shi Ji, a famous expert of traditional Chinese medicine, thinks that constipation is closely related to lung despite the fact that it is often due to dysfunction of large intestine. Lung and large intestine are the exterior and the interior; the heat of lung is transferred to large intestine, resulting in dysfunction of large intestine; lung is the upper source of water, and because of the closure of lungqi, there is abnormal liquid metabolism, causing driness of liquid, hence constipation. Therefore, the clinical treatment should be based on lung theory in order to achieve satisfactory effects. Related Articles | Metrics

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A brief analysis of infantile eczema based on the theory of preventive treatment for diseases in Chinese medicine ZHANG Xia 2018, 10 (2):  180-182.  doi: 10.3969/j.issn.1674-3865.2018.02.028 Abstract ( 388 )   PDF (406KB) ( 87 )   Save With the theory of preventive treatment for diseases in Chinese medicine as a guide, this paper tries to discuss the prevention and treatment of the infantile eczema from the perspective of its pathogenic mechanism, pointing out:"fetal toxicity" and "body of pure yang" are the main causes of infantile eczema; "regulating the spleen and stomach" and "treatment of mothers" are important measures of treatment; "combining acupuncture with herbs" and "strengthening physique" are the main methods of preventing recurrence. The above methods are applied to clinical practice and achieve good effect. Related Articles | Metrics

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Yinchen Tuihuang decoction in the treatment of neonatal jaundice ZHANG Yan，YUAN Ye，LIU Xiaowei，QIN Yanhong 2018, 10 (2):  182-184.  doi: 10.3969/j.issn.1674-3865.2018.02.029 Abstract ( 506 )   PDF (419KB) ( 75 )   Save Neonatal jaundice is a common disease frequently occurring in the newborn. Pathological jaundice will persist and it's difficult to cure the neonates with unknown causes. Chief physician Jia Liujin is famous in China in the field of traditional Chinese medicine, and has rich clinical experience in the treatment of neonatal jaundice, especially when the jaundice persists or relapses. According to the treatment principle of "If the wetness is not removed, the heat will not be cleared, and the jaundice persists", he puts forward a treatment program of removing wetness, clearing heat and eliminating jaundice, and develops the Yinchen Tuihuang decoction, which is very effective in eliminating jaundice clinically. Related Articles | Metrics