Table of Content

25 December 2016, Volume 8 Issue 6 Previous Issue    Next Issue

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Xinpi Yang'er granules combined with magnesium sulfate in the treatment of infantile capillary bronchitis LU Qingguo，HE Mingsheng，XING Yaohua，ZHANG Min，LIU Wanfen，HUANG Yingjiu 2016, 8 (6):  557-559.  doi: 10.3969/j.issn.1674-3865.2016.06.001 Abstract ( 462 )   PDF (322KB) ( 97 )   Save Objective:To study the effect of Xingpi Yang'er granules combined with magnesium sulfate in the treatment of infantile capillary bronchitis. Methods:A total of 320 cases of infantile capillary bronchitis were hospitalized for treatment in Xiushui County Maternal and Child Health Care Hospital from June 2015 to June 2016, who were randomly divided into four groups,with 80 cases in each group: ribavirin group(A),ribavirin+magnesium sulfate group(B),ribavirin+Xingpi Yang'er granules group(C) and ribairin+Xingpi Yang'er granules+magnesium sulfate group（D）.Elementary treatment was given to the 4 groups of infants according to their conditions, including inhaling oxygen, reducing sputum, and relieving wheezing, which lasted five to seven days. Observe the treatment effect, adverse reactions, length of hospital stay and time for signs and symptoms to disappear. Results：The total effective rate of group A，B and C was 71.3%(57/80)，72.5%(58/80) and 73.8%(59/80) respectively,which was lower than that of group D(90.0%,72/80), and the difference was of statistical significance(P<0.008 3).The time for signs and symptoms to disappear and the length of hospital stay were shorter in group D than the other 3 groups, and there was statistical difference(P<0.05).There was no adverse reactions in all the 4 groups. Conclusion：The treatment of Xingpi Yang'er ganules combined with magnesium sulfate for infantile capillary bronchitis can shorten the treatment course and relieve clinical symptoms, which is effective, safe and convenient. Related Articles | Metrics

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Study on the effect of early intervention and follow-up on the development of high risk infants WANG Zhangxing，TONG Yanmei，CHEN Mingqiu 2016, 8 (6):  560-563.  doi: 10.3969/j.issn.1674-3865.2016.06.002 Abstract ( 550 )   PDF (403KB) ( 100 )   Save Objective:To study the clinical significance of early intervention and follow-up in the development of high risk infants. Methods:Totally 106 cases of high risk infants who accepted the intervention and follow-up immediately after birth were included as neonatal intervention group, 58 cases of high risk infants who accepted intervention one month after birth were included as infant intervention group, and 120 cases of healthy neonates were included as the control group; regular follow-up and evaluation were performed. Observe the physical development at six months and 12 months after birth in the three groups. In the neonatal intervention group and control group, neurological behavior was determined at 1 week and 4 weeks after birth. Observe the gross motor development, primitive reflex disappearance and establishment time of posture reflex. Results：At 6 months after the birth the body length, weight and head circumference of neonatal and infant intervention group were lower than the control group with statistical difference(P<0.05); at 12 months after birth the height, weight and head circumference of three groups showed no statistical difference(P>0.05); 1 week after birth the NBNA score of neonatal intervention group was lower than the control group(P<0.05); 4 weeks after birth the NBNA scores of the two groups had no statistical difference(P>0.05); the establishment time of gross motor development in sitting, crawling and postural reflex of the neonatal intervention group and the control group had no statistical difference(P>0.05),which were better than those of infant intervention group, and the difference was statistically significant(P<0.05); gross motor development in rising, turning over and the disappearance time of primitive reflex in all these groups had statistical difference(P<0.05). Conclusion：Early intervention and regular follow-up have important clinical significance in the recovery and development of high risk infants. Related Articles | Metrics

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Study on therapeutic effects of internal and external therapy with Ping Chuan Ke Wai Fu powder in treating cough and asthma during asthma attack in children HUANG Meifen,WANG Lining,DENG Yuzhi,CHEN Guang 2016, 8 (6):  564-566.  doi: 10.3969/j.issn.1674-3865.2016.06.003 Abstract ( 402 )   PDF (358KB) ( 127 )   Save Objective:To verify the effectiveness of Ping Chuan Ke Wai Fu powder in internal and external therapy for cough and asthma during asthma attack in childen. Methods:Collect cases of children who were diagnosed with asthma attack and with cough and asthma and analyze their data.Record the score of main syndrome before treatment and after treatment. Results：The total effective rate was 100%. After treatment,the syndrome score of cough, asthma, guring with sputum, and wheezing rale and the total score were significantly improved, and there was statistical difference compared with those before treatment(P<0.05). Conclusion：Ping Chuan Ke Wai Fu powder in internal and external therapy has a significant curative effect in treatment of cough and asthma it takes less time to be effective. Related Articles | Metrics

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Observation on the clinical effect of Pingfu powder in the treatment of acute mesenteric lymphadenitis in children LI Shaochun 2016, 8 (6):  567-569.  doi: 10.3969/j.issn.1674-3865.2016.06.004 Abstract ( 479 )   PDF (311KB) ( 118 )   Save Objective:To observe the curative effect of Pingfu powder (No.1 and No.2) in the treatment of children with mesenteric lymphadenitis. Methods:A total of 106 children visiting the outpatient department were randomly divided into two groups: observation group and control group,53 children in each group. For the observation group, Pingfu powder(No.1 and No.2) was taken orally respectively according to the different clinical syndrome. For control group, azithromycin suspension was given, and acyclovir sustained release tablets were also given. The treatment lasted 7 days for both groups as a course. Results：The cure rate was 77.36%(41/53) for observation group and 50.94%(27/53) for control group, and there was statistical difference(P＜0.05). Some children had more times of bowel movement after taking Pingfu powder(No.2) for several days in the observation group, but returned to normal after the treatment course. Some children in control group had skin rash and gastrointestinal symptoms. Conclusion：Pingfu powder has significant effect in the treatment of children with acute mesenteric lymphadenitis, and it has no obvious adverse reactions, so it should be clinically promoted and used. Related Articles | Metrics

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Clinical analysis of the prognostic factors of neonatal severe hypoxic ischemic encephalopathy HUANG Weiqing，PENG Xiaoming 2016, 8 (6):  569-571.  doi: 10.3969/j.issn.1674-3865.2016.06.005 Abstract ( 455 )   PDF (314KB) ( 153 )   Save Objective:To investigate the prognostic factors of neonatal severe hypoxic ischemic encephalopathy. Methods:A total of 131 cases of HIE neonates were admitted and treated in Children's Hospital of Hunan Province from Jan. 2011 to Dec. 2014，and a regression analysis was make on the prognostic factors. Results：Single factor analysis showed that 5 min Apgar score，convulsions，coma，pH value，BE value and organ damage were the prognostic risk factors of severe HIE in neonates. Multi-factor Logistic analysis showed that the 5 min Apgar score less than 3(OR＝4.256，95%CL 1.501~15.432）and BE value no more than -10 mmol/L（OR＝37.208，95%CL 6.053~42.105） were the independent prognostic rick factors of severe HIE (P<0.05)；the hospital stay shorter than 72 h(OR＝0.098，95%CL 0.032~0.367) was the protective factor of severe HIE in neonates. Conclusion：There are many factors that influence the prognosis of severe HIE in neonates. It is the key to the preventing severe neonatal HIE to find these factors as early as possible，so clinical physicians should pay attention to it and perform early intervention. Related Articles | Metrics

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Efficacy of triple drug therapy combined with L-GMI collutory in the treatment of Helicobacter pylori infection in children TANG Wei，ZHU Zhanghua，LI Yuqin 2016, 8 (6):  572-575.  doi: 10.3969/j.issn.1674-3865.2016.06.006 Abstract ( 473 )   PDF (400KB) ( 147 )   Save Objective:To investigate the therapeutic effect of triple drug therapy combined with L-GMI collutory in the eradication of Helicobacter pylori(H. pylori) infection in children. Methods:From January 2010 to December 2014, in Affiliated Hospital of Jiangsu University, 120 H. pylori positive cases confirmed by 13C- breath test in the outpatient department of pediatrics were randomly divided into observation group and control group, each with 60 cases. Control group was treated with omeprazole+clarithromycin+amoxicillint, while the observation group was treated with L-GML collutory in addition to the treatment for control group for 2 weeks. Observe the curative effect in 7 d and 14 d after the treatment, the eradication rate of H. pylori after drug withdrawal for 4 weeks and the recurrence rate after 1 year. Results：The total effective rate of the observation group was 90%(54/60) and 96.7%(58/60) after 7 and 14 days, which was higher than that in the control group(73.3%,44/60) and （83.3%,50/60), and the difference was statistically significant(P<0.05). The eradication rate of H. pylori in the observation group was 80%(48/60), higher than that in the control group(53.3%,32/60), the difference being statistically significant(P<0.01). The recurrence rate of H. pylori in the observation group was 14.6%(7/48), lower than that in the control group(37.5%,12/32), and the difference was statistically significant(P<0.05). Conclusion：Conventional drug therapy combined with L-GMI collutory can significantly improve the cure rate and decrease the recurrence rate of H. pylori in children. Related Articles | Metrics

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Efficacy analysis of Bairui particles as adjuvant therapy for children with mycoplasma pneumonia LI Yanyan, CHEN Qiwei 2016, 8 (6):  575-577.  doi: 10.3969/j.issn.1674-3865.2016.06.007 Abstract ( 690 )   PDF (344KB) ( 113 )   Save Objective:To observe the clinical efficacy of Bairui particles as adjuvant therapy for children with mycoplasma pneumonia. Methods:Totally 100 children with mycoplasma pneumonia were randomly divided into an observation group(n=50) and a control group(n=50), according to the order of admission. In addition to convention therapy, erythromycin and azithromycin were also used for the control group, and Bairui particles together with the therapy for control group was used for the observation group. Compare the total effective rate, time of abatement of fever ,time for cough and lung rales to disappear and the occurrence of adverse reactions. Results：The total effective rate of the observation group was 94%, and the control group 80%;the difference had statistical significance(P<0.05). There was significantly difference(P<0.05) on time of fever abatement, cough and lung rales between observation group and control group. The incidence of adverse drug reactions in the two groups showed no significant difference(P>0.05). Conclusion：Bairui particles as adjuvant treatment for children with mycoplasma pneumonia can significantly promote the clinical efficacy and improve symptoms and signs, which is effective and safe and should be widely used in clinics. Related Articles | Metrics

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Effect of Jianpi Yifei oral solution on airway inflammation and lung function in children with bronchial asthma at remission stage SUN Honghua 2016, 8 (6):  578-580.  doi: 10.3969/j.issn.1674-3865.2016.06.008 Abstract ( 368 )   PDF (330KB) ( 149 )   Save Objective: To investigate the effects of Jianpi Yifei oral solution on serum inflammatory cytokines and lung function in children with bronchial asthma at remission stage. Methods:Sixty children with bronchial asthma at remission stage admitted to Department of Pediatrics, the Second Hospital of Chaoyang, from January 2014 to February 2015, were included and divided randomly into observational group and control group, with 30 cases in each group. Jianpi Yifei oral solution and Budesonide powder for inhalation were administered for 3 months in the observational and control groups, respectively. Serum tumor necrosis factor-α and interleukin-6 and lung function were determined before and 3 months after treatment. Results：Serum tumor necrosis factor-α, interleukin-6, forced volume vital capacity, and forced expiratory volume in one second were significantly decreased after treatment, compared with before treatment(P<0.05). Serum tumor necrosis factor-α, interleukin-6, forced volume vital capacity, and forced expiratory volume in one second were similar before and after treatment(P>0.05). Conclusion：Jianpi Yifei oral solution can significantly inhibit airway inflammatory reaction and improve lung function in children with bronchial asthma at remission stage, and the effects are similar to those of hormone drugs. Related Articles | Metrics

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Clinical value of bronchoscopy in the treatment of postoperative pulmonary atelectasis in children undergoing thoracic surgery YI Liwen 2016, 8 (6):  581-582.  doi: 10.3969/j.issn.1674-3865.2016.06.008 Abstract ( 477 )   PDF (315KB) ( 133 )   Save Objective：To evaluate the clinical value of bronchoscopy in the treatment of postoperative atelectasis in children with cardiothoracic surgery. Methods：From June 2012 to December 2015, 30 children with pulmonary atelectasis after surgery were admitted to Hunan Provincial Children's Hospital, and bronchoscopy was performed to investigate the therapeutic effectResults：After treatment, 18 cases(56.0%) were cured, 11 cases(36.7%) improved, and 1 case(3.3%) failed. The total effective rate was 96.7%. No adverse reactions occurred. Conclusion：Bronchoscopy is a safe and effective treatment for postoperative atelectasis in children receiving cardiothoracic surgery. It is worthy of being popularized. Related Articles | Metrics

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Clinical efficacy analysis and the follow-up survey of the children with Henoch-Schonlein purpura ZHAI Wensheng,ZHANG Qiuyue 2016, 8 (6):  583-585.  doi: 10.3969/j.issn.1674-3865.2016.06.010 Abstract ( 505 )   PDF (334KB) ( 125 )   Save Objective:To analyze the clinical effects and the follow-up survey of 155 children with Henoch-Schonlein purpura(HSP),raising awareness of the disease. Methods:To retrospectively analyze the clinical data of the 155 cases,who were treated from July 2013 to May  2014 and had been followed up for 6 months. Results：The male to female ratio in 155 cases was 1.5 to 1; HSP occurred more commonly in winter and spring; most of patients were school-age children; upper respiratory tract infection was the most important predisposing factor.The 155 cases all had the typical skin purpura,and about 54.2% of the patients were with the joint symptoms,46.5% with the digestive tract symptoms,6.5% with renal damage, and 13.5% with nephritis. Of the 155 cases,136 cases(87.7%) were cured;13 cases(8.3%) were remarkably improved, and 6 cases(3.9%) were improved; the treatment was effective in all cases. After 6 months of follow-up, the recurrence rate was 7.1%. Conclusion：The clinical effect of traditional Chinese medicine on HSP is positive,and it is worthy of being popularized and applied in pediatric clinics. Related Articles | Metrics

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Clinical analysis of purulent meningitis in children and its prognostic influencing factors ZHANG Xiaomin, YAO Chunmei,DONG Zhiheng 2016, 8 (6):  586-589.  doi: 10.3969/j.issn.1674-3865.2016.06.011 Abstract ( 569 )   PDF (426KB) ( 121 )   Save Objective:To analyze the changes of complete blood count(CBC), C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), and calcitonin peptide(PCT) in children with purulent meningitis. Methods:A total of 104 children with purulent meningitis were treated in Pediatric Department of Kaifeng Children's Hospital and Neihuang County People's Hospital of Henan Province from Jan. 2015 to May 2016. The peripheral elbow blood was taken respectively on admission and 72 h after admission to determine the level of complete blood count, CRP, ESR and PCT. According to the prognosis, these children were divided into two groups: the good prognosis group(A, n=34) and the bad prognosis group(B, n=70). Compare the routine blood test, the level and changes of the inflammatory marker indexes before and after treatment between the two groups. Results：There were no deaths; 34 children were cured, 60 improved and 10 children were discharged on the patients' request. The onset mostly occurred in spring and fall, accounting for 61%; about 64% was induced by infection. The use of antibiotics before admission accounted for 81%, and 61% were abnormal on head examination. There was no statistical difference on RBC between the two groups respectively on admission or 72 h after admission(P>0.05). At 72 h after admission, WBC, CRP and calcitonin were all lower than on admission, ESR in group A and PLT in group B were also lower, and the difference was of statistical significance(P<0.05). On admission and at 72 h after admission, RBC, PLT and LYC of Group B were lower than group A, while WBC, CRP, ESR and calcitonin were high than group A, there being statistical difference(P<0.05).At 72 h after admission, the decrease degree of LYC in group A was lower than that in group B, while the decrease degree of CRP, ESR and calcitonin was higher than that in group B, and there was statistical difference(P<0.05). Conclusion：The pathogenesis of purulent meningitis is complicated; inflammation level, routine blood test and ESR can be the prediction indexes of prognosis; dynamic determination of relevant indexes also can predict the curative effect. Related Articles | Metrics

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Clinical effect of saccharomyces boulardii sachets in the treatment of children with acute diarrhea and its impact on the cellular immune function ZHAO Jinfang，ZHAO Liming 2016, 8 (6):  589-591.  doi: 10.3969/j.issn.1674-3865.2016.06.012 Abstract ( 407 )   PDF (350KB) ( 103 )   Save Objective:To study the clinical effect of saccharomyces boulardii sachets in children with acute diarrhea and its impact on the cellular immune function. Methods:A total of 88 children with acute diarrhea treated from May 2013 to May 2014 in our hospital were selected. The subjects were divided into control group and test group according to different therapies, 44 cases in each group. The control group received the conventional therapy; the test group was given the conventional therapy and saccharomyces boulardii. The treatment lasted for 4 to 7 days. The clinical effect and the level of peripheral blood T-lymphocyte cell were observed. Results：The total effective rate of test group(95.5%,42/44) was significantly higher than that of control group(75.0%,33/44)(P＜0.05); after treatment, the level of CD3+, CD4+/CD8+ and CD4+ of test group was significantly higher than that of control group(P＜0.05); the level of CD8+ of test group was significantly lower than that of control group(P＜0.05). Conclusion：For children with acute diarrhea, the saccharomyces boulardii sachets can improve the clinical effect, the cellular immune function and the children's prognosis. It is worthy of promotion. Related Articles | Metrics

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Observation on the curative effect of mechanical expectoration in auxiliary treatment of infantile pneumonia WANG Xiaowei,LIU Tieying，LI Yingchun 2016, 8 (6):  592-594.  doi: 10.3969/j.issn.1674-3865.2016.06.013 Abstract ( 269 )   PDF (324KB) ( 144 )   Save Objective:To explore therapeutic effect of mechanical expectoration in the treatment of infantile pneumonia. Methods:From March 2015 to December 2015, 134 hospitalized children with infantile pneumonia were hospitalized in our hospital, and they were randomly divided into experimental group and control group, 66 cases in the experimental group, 68 cases in the control group. Two groups of patients were given the conventional anti-inflammatory and symptomatic treatment, and the experimental group also received mechanical expectoration treatment, while the control groups were knocked on the back to produce sputum. After 5 days of treatment, observe the treatment effect, time of symptoms to disappear and the hospital stay in the two groups. Results：The cough, lung rales disappearance time and the average hospitalization days of the experimental group were significantly less than the control group, and the total effective rate is significantly higher in the experiment group(94.0%,62/66) than in the control group(79.4%,54/68), the difference being statistically significant（P<0.05）.During the treatment, there was no adverse reaction in the experimental group. Conclusion：On the basis of conventional treatment such as anti-inflammation and atomization for infantile pneumonia, mechanical auxiliary expectoration treatment should be given in time when body temperature is steady, which can shorten the recovery time and hospital stay obviously. It is safe and effective. Related Articles | Metrics

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Differential diagnosis value of routine urine test for the children with acute appendicitis ZHAO Dandan 2016, 8 (6):  594-596.  doi: 10.3969/j.issn.1674-3865.2016.06.014 Abstract ( 249 )   PDF (379KB) ( 135 )   Save Objective:To observe the effect and value of urine test in the differential diagnosis of children with acute appendicitis. Methods:A total of 83 children with acute appendicitis treated in Shenyang Medical College Affiliated Hospital from Feb.2015 to Feb.2016 were randomly divided into two groups: control group(41 cases) and observation group(42 cases).The control group was performed differential diagnosis by ultrasonic examination, and the observation group by routine urine test. Compare the Results: of the two groups. Results：All the 83 children were confirmed to be with acute appendicitis by operation and pathological detection. The detection rate was 92.86%(39/42) in observation group, which was higher than that of control group(73.17%,30/41), and there was statistical difference(P<0.05). Conclusion：Routine urine test has higher detection rate in the differential diagnosis of children with acute appendicitis, so it is worth of being recommended and used in clinics. Related Articles | Metrics

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Gamma globulin combined with glucocorticoid in the treatment of children with idiopathic purpura: an observation on the effect YANG Haixia 2016, 8 (6):  597-599.  doi: 10.3969/j.issn.1674-3865.2016.06.015 Abstract ( 310 )   PDF (318KB) ( 123 )   Save Objective:To observe the curative effect of gamma globulin combined with glucocorticoid in the treatment of children with idiopathic thrombocytopenic purpura. Methods:A total of 80 children with ITP who were hospitalized for treatment in Hunan Children's Hospital from Jan. 2015 to may 2016 were randomly divided into two groups: observation group(40 children) and control group(40 children). The control group was given glucocorticoid for treatment, and the observation group was given Gramma globulin in addition to glucocorticoid. The treatment course lasted 21 to 28 days. Observe the curative effect in the two groups; the time of platelet count to increase and to return normal was also recorded. Results:The total effective rate in observation group was 95.0%(38/40), significantly higher than that of control group(77.5%,31/40), and the difference was statistical(P<0.05). The time of platelet count to increase and to return to normal in observation group was shorter than that in control group, and there was statistical difference(P<0.05). Conclusion：Gamma globulin combined with glucocorticoid achieves significant effect in the treatment of ITP children. Related Articles | Metrics

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Analysis of the causes of clinical misdiagnosis in children with sinusitis WANG Ranran，XIAO Xiangli，DING Feng，QIN Li 2016, 8 (6):  599-601.  doi: 10.3969/j.issn.1674-3865.2016.06.016 Abstract ( 361 )   PDF (376KB) ( 115 )   Save Objective:To explore the causes of misdiagnosis of sinusitis in children, in order to improve the ability of diagnosis and differential diagnosis and to reduce the errors. Methods:Totally 92 cases of children with sinusitis were misdiagnosed as other diseases, who were from the Department of Pediatrics, the Red Cross Hospital of Wuhan, and the Department of Otolaryngology, Hankou Hospital of Wuhan, between January 2013 to October 2015.The cases data were analyzed. Results:Totally 72 cases(78.3%) were confirmed as sinusitis by endoscopy or electronic nasopharyngoscope examination among which 12 cases were complicated with adenoid hypertrophy,7 cases with allergic rhinitis and 9 cases with secretory otitis media and 2 cases with tonsil hypertrophy. The remained 20 cases(21.7%) were diagnosed as sinusitis by sinus CT examination. Conclusion：Sinusitis in children is often misdiagnosed, because of children's lack of cooperation, which Results: in a lack of comprehensive and systemic examination, and the lack of the comprehensive analysis of the condition, and the reasons of the failed treatment were not investigated, either. Clinicians should make a detailed inquiry of the medical history, carefully check the body, improve the nasal endoscopic or CT examination and expand the diagnostic thinking, so as to avoid misdiagnosis and wrong treatment. Related Articles | Metrics

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Application value of combined detection PCT,hs-CRP and WBC in the early diagnosis of neonatal sepsis FENG Gaimei 2016, 8 (6):  602-604.  doi: 10.3969/j.issn.1674-3865.2016.06.017 Abstract ( 450 )   PDF (277KB) ( 131 )   Save Objective:To study the application of combined detection of PCT,hs-CRP and WBC in the early diagnosis of neonatal sepsis. Methods:A total of 68 neonates diagnosed with sepsis from Jan. 2013 to Jan. 2016 were chosen as the observation group, and 68 healthy neonates in the same period were included as the control group. Enzyme-linked fluorescence analysis was used to detect PCT, immuno turbidimetry was used to detect hs-CRP and Sysmex 800 blood analyzer was used to analyze WBC. Results:The value of PCT,hs-CRP and WBC was remarkably higher in the observation group than in the control group before treatment(P<0.05), but after treatment, these values significantly decreased in observation group, and there was statistical difference compared with those before treatment(P<0.05). The combined detection of PCT,hs-CRP and WBC was higher in specificity of diagnosis, positive prediction value and negative prediction value when compared with the combined detection of any two items. Conclusion：The combined detection of PCT, hs-CRP and WBC can be used in the early diagnosis of neonatal sepsis, which helps to improve the diagnosis accuracy. Related Articles | Metrics

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Assessment Results: analysis of the universality and specificity of the life quality questionnaire for children with asthma WEI Jiemiao，YAN Hong，CHEN Xiaogeng 2016, 8 (6):  604-606.  doi: 10.3969/j.issn.1674-3865.2016.06.018 Abstract ( 361 )   PDF (302KB) ( 91 )   Save Methods;A total of 68 neonates diagnosed with sepsis from Jan. 2013 to Jan. 2016 were chosen as the observation group, and 68 healthy neonates in the same period were included as the control group. Enzymelinked fluorescence analysis was used to detect PCT, immuno turbidimetry was used to detect hsCRP and Sysmex 800 blood analyzer was used to analyze WBC. Results;The value of PCT,hsCRP and WBC was remarkably higher in the observation group than in the control group before treatment(P<005), but after treatment, these values significantly decreased in observation group, and there was statistical difference compared with those before treatment(P<005). The combined detection of PCT,hsCRP and WBC was higher in specificity of diagnosis, positive prediction value and negative prediction value when compared with the combined detection of any two items. Conclusion;The combined detection of PCT, hsCRP and WBC can be used in the early diagnosis of neonatal sepsis, which helps to improve the diagnosis accuracy. Related Articles | Metrics

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The analysis of clostridium difficile colonization and infection in infants with diarrhea GUO Yanan,WANG Jun,LI Jiayao，WANG Qiuping，LIU Xinzhu 2016, 8 (6):  607-609.  doi: 10.3969/j.issn.1674-3865.2016.06.019 Abstract ( 451 )   PDF (304KB) ( 115 )   Save Objective;To analyze the assessment results analysis of the universality and specificity of the life quality questionnaire for CA children. Methods A total of 42 CA children who were confirmed in Shenyang Children's Hospital from Jan. to Dec. 2015 were chosen as the CA group, and 45 children who were disgnosed with upper respiratory tract infection in the same period were included as the control group. Both groups of children were assessed by univesality and specificity of life quality questionnaire. Results;In the assessment of univesality of life quality questionnaire, the factor score on peer relationship, school life, depression experience, anxiety experience and body experience and the total satisfaction score were both lower in CA group than those in control group (P＜0.05). In the assessment of specificity of life quality questionnaire, the factor score on asthmatic symproms, limited movement, reaction to stimulation, psychological state and attention to their own health and AQLQ total score were significantly higher in CA group than those in control group (P＜0.05). Conclusion;The present situation of universality and specificity of life quality is not very good. Related Articles | Metrics

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Study on anal fistula in children treated by Shuangzishen lotion and incision seton therapy HU Deming 2016, 8 (6):  610-612.  doi: 10.3969/j.issn.1674-3865.2016.06.020 Abstract ( 340 )   PDF (334KB) ( 101 )   Save Objective:To study the clinical effect of Shuangzishen lotion combined with incision seton therapy for infantile anal fistula. Methods:Totally 60 cases of anal fistula were randomly divided into study group and control group, with 30 cases in each group. The patients in two groups underwent incision seton therapy. We used routine flushing with saline after surgery in the control group, while Shuangzishen lotion flushing in the study group. The patients in the two groups were observed concerning the treatment effect, adverse reaction and recurrence rate. Results:In the study group the total effective rate was 93.33%, while in the control group it was 73.33%, which showed that the total efficiency of the treatment group was significantly higher than the control group(P<0.05). The incidence of itching and pain in the observation group were significantly lower than that in the control group(P<0.05).The two groups of patients were followed up for 1 year, and in the observation group there were 2 cases of recurrence(6.67%), while in the control group 9 cases(30%), the recurrence rate in the observation group being significantly lower than the control group(P<0.05). Conclusion：The clinical curative effect of incision seton therapy combined with fumigating and washing is significant in the treatment of anal fistula in children. Related Articles | Metrics

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Significance of plasma pre albumin combined with white blood cell count in predicting of coronary artery disease in patients with Kawasaki disease LIANG Fang,LI Chaoxiong,ZHANG Cuiyuan 2016, 8 (6):  612-615.  doi: 10.3969/j.issn.1674-3865.2016.06.021 Abstract ( 330 )   PDF (406KB) ( 135 )   Save Objective:To analyze the changes of plasma pre albumin(prealbumin, PA) and white blood cell count(total leukocyte count, TLC) in patients with Kawasaki's disease in order to investigate the significance of combined analysis of PA and TLC changes in predicting coronary artery disease. Methods:A retrospective analysis of 83 cases of children with Kawasaki's disease in our hospital from January 2013 to January 2016 were carried out. Analyze the case data，which included the plasma level of TLC, PA and the Results: of ultrasound examination of the coronary artery, etc. Use t test, Chi-square test and area under the ROC curve and the calculation of the cut-off value of statistical Methods to analyze the correlation between PA, TLC and the coronary artery disease. Results:In the acute phase of patients with Kawasaki, the plasma Mg level was (72.39±46.81)×109/L PA, which was significantly decreased compared with the normal reference value, and the TLC count was (16.47±6.49)×109/L, which was significantly higher than the normal reference value, and the difference was statistically significant(P＜0.05). The ROC curve was used to calculate the area of PA, and the AUC was 0.699, which was of diagnostic value. When the threshold value of PA level was 48.5 mg/L, the sensitivity and specificity of predicting coronary artery dilatation were 73.3% and 64.5%, respectively. Conclusion：PA and TLC have significant changes in the acute stage of Kawasaki's disease. Combined analysis of changes in PA and TLC may have important implications for the prediction of coronary artery disease, but can not be used to judge the type and extent of coronary artery disease. Related Articles | Metrics

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Effect of fluticasone propionate aerosol combined with montelukast sodium chewable tablets in treating cough variant asthma with allergy to mites ZENG Jizan 2016, 8 (6):  616-618.  doi: 10.3969/j.issn.1674-3865.2016.06.022 Abstract ( 412 )   PDF (389KB) ( 122 )   Save Objective:To observe the clinical effect of fluticasone propionate aerosol combined with montelukast sodium chewable tablet in treating cough variant asthma in children with mite allergies. Methods:From March 2014 to March 2016, 90 children with cough variant asthma who were allergic to mites were enrolled in Department of Pediatrics, Chang'an Hospital of Dongguan City, and were divided into control group and observation group by digital random method. The control group was treated with fluticasone propionate aerosol, and the observation group was given montelukast sodium chewable tablets in addition to the treatment for control group, 3 months as a course of treatment; the two groups were treated for 2 courses. Observe the clinical effect, day cough score, night cough score, and the pulmonary function indexes, such as FEV1, peak expiratory flow rate(PEF) and FEV1% of the two groups. The recurrence of the two groups and the incidence of adverse reactions were also observed. Results:The total effective rate in the observation group was 91.1%(41/45), which was significantly higher than that in the control group(75.6%, 34/45); the difference was significant(P<0.05). The cough score, cough remission and disappearance time were significantly better in the observation group than those in the control group(P<0.05). The FEV1, PEF and FEV% of the two groups after treatment were significantly higher than those before treatment(P<0.05). The FEV1, PEF and FEV% of the observation group were significantly better than those of the control group(P<0.05). There was no significant difference in the recurrence rate and adverse reaction rate between the two groups(P>0.05). Conclusion：Clinical application of fluticasone propionate nasal spray combined with montelukast sodium chewable tablets in the treatment of mite-allergic children with cough variant asthma has a significant clinical effect, which can effectively improve the clinical symptoms of children, and is safe and reliable, so it should be clinically promoted and used. Related Articles | Metrics

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Observation on the effect of Bifid Triple Viable tablet combined with montmorillonite powder in the treatment of antibiotic-associated diarrhea in children ZHU Lili 2016, 8 (6):  619-621.  doi: 10.3969/j.issn.1674-3865.2016.05.023 Abstract ( 348 )   PDF (355KB) ( 99 )   Save Objective:To observe the clinical therapeutic effect of probiotics and gastrointestinal mucosal protective agents on antibiotic-associated diarrhea in children. Methods:A total of 160 cases of children with antibiotic-associated diarrhea were divided into control group and observation group,each group with 80 cases,according to odd or even number of clinical visits.Both groups were given montmorillonite powder,and the observation group was added Bifid Triple Viable tablets taken orally,the dosage varying with different ages.The treatment stopped when the diarrhea stopped.After treatment,compare the time for fever to recede,the time for diarrhea to stop,the time for bowel movement to return normal,the clinical effect and the adverse reactions between the two groups. Results:The total effective rate of the observation group was better than that of the control group,the difference being of statistical significant(P<0.05).Concerning the time of the abatement of fever,the time for diarrhea to stop,and the time for bowel movement to return normal,the observation group was better than the control group,and the difference was statistical(P<0.05).No adverse reaction was observed in the two groups. Conclusion：The effect of Bifid Triple Viable tablets combined with montmorillonite powder is better than that of single use of montmorillonite,and the combination use should be popularized clinically. Related Articles | Metrics

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Clinical study of Montelukast early intervention on severity of wheezing in infants and prevention of the development of asthma ZANG Yaqin，XU Liang，SHEN Yaohong 2016, 8 (6):  622-625.  doi: 10.3969/j.issn.1674-3865.2016.06.024 Abstract ( 350 )   PDF (397KB) ( 112 )   Save Objective:To study the effect of Montelukast early intervention in wheezing of infants and in the prevention of asthma. Methods:Between January 2013 and January 2015, 96 pediatric patients with wheezing were admitted to the Suzhou Municipal Hospital, and they were divided randomly into observation group and control group, each with 48 cases. The control group was treated with conventional therapy, while Montelukast sodium chewable tablets were given in observation group on the basis of treatment for control group. Observe the short-term effect and the clinical symptom score, and the incidence of asthma was followed up for 1.5 years. Results:The total short-term rate was 93.75% in observation group and which was significantly higher than that of control group(79.17%), the difference being significant(P<0.05). After treatment, symptom scores for observation group significantly reduced, which were significantly lower than the control group, the difference being significant(P<0.05). Wheezing episodes for the observation group were significantly fewer than the control group, and the average duration was significantly shorter than the control group within 1 and a half years, the difference being significant(P<0.05). After 1 and a half years of follow-up, the incidence of asthma in the observation group was significantly lower than the control group, the difference being significant(P<0.05). No obvious adverse reaction occurred in both groups. Conclusion：Montelukast early intervention can improve outcomes, alleviate clinical symptoms of acute exacerbation and reduce the incidence of asthma after wheezing. Related Articles | Metrics

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Clinical application of serum ferritin detection in children with nutritional iron deficiency anemia LIU Lanxiang,ZHU xingyuan, ZHENG Suping, LIU Yunhua 2016, 8 (6):  625-627.  doi: 10.3969/j.issn.1674-3865.2016.06.025 Abstract ( 345 )   PDF (325KB) ( 128 )   Save Objective:To study the application of serum ferritin detection in children with nutritional iron deficiency anemia. Methods:From Jan.2013 to Jan.2016, a total of 2 896 children were found to be with iron deficiency anemia on routine physical examination in Hunan Children's Hospital. These children were divided into 3 groups according to their age: 6 months to 1 year old in group A(1 092 children),1 to two years old in group B(980 children),2 to 3 years old in group C(824 children).Detect serum level of ferritin in these children. The cases of iron decrease, iron deficiency anemia and iron deficiency were also detected. Results:The serum level of ferritin in group A and group B was significantly lower than group C, there being statistical difference(P<0.01),but there was no statistical difference between group A and group B(P>0.05). There were 457 cases(15.8%) of iron decrease, 437 cases(15.1%) of iron deficiency anemia and 801 cases(27.7%) of iron deficiency. The detection rate of iron decrease in group A and B was significantly higher than in group C, and there was statistical difference(P<0.05), but there was no difference between group A and group B(P>0.05).With the child growing up, the detection rate of iron deficiency anemia and iron deficiency decreased gradually, and comparing any two groups among the 3 groups, there was statistical difference(P<0.05). Conclusion：Iron deficiency is quite common in children between 6 months and 3 years old. In order to enhance parents' understanding about the early prevention of iron decrease and iron deficiency anemia and reduce the occurrence of anemia, the serum ferritin detection should be included in the routine physical examinations, and thus the parents can be taught to add solid food in time and to give balanced diet, achieving the aim of preventing nutritional iron deficiency anemia. Related Articles | Metrics

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Observation on the effect of combined cetirizine therapy for children with cough variant asthma CHEN Lili 2016, 8 (6):  628-630.  doi: 10.3969/j.issn.1674-3865.2016.06.026 Abstract ( 331 )   PDF (333KB) ( 104 )   Save Objective:To observe the effect of combined cetirizine therapy for children with cough variant asthma. Methods:A total of 120 children with cough variant asthma were admitted to No.245 Hospital of Shenyang from Aug. 2014 to Mar. 2016, and they were randomly divided into two groups: 60 in observation group and 60 in control group. The control group was given cetirizine drops and the observation group received additional treatment, taking Shegan Mahuang decoction orally every day, continuously for two weeks. Compare the curative effect, disappearance time of signs and symptoms and adverse reactions between the two groups. The relapse was followed up six months later. Results:The total effective rate of observation group was 91.7%(55/60),higher than that of the control group(71.7%，43/60),and the difference was statistical(P<0.05).The time for asthma to disappear, the lasting time of asthma and the time for pulmonary wheezes to disappear in observation group were all significantly less than those of control group, and there was statistical difference(P<0.05).There were two cases of relapse(3.33%) in observation group, lower than that of control group (8 cases,13.33%) with statistical difference（P<0.05）. The rate of adverse reactions in observation group was 3.33%(2/60), which was significantly lower than the control group(13.33%，8/60), and there was statistical difference(P<0.05). Conclusion：The combined therapy of cetirizine with Shegan Mahuang decoction has great clinical effect on children with cough variant asthma, with fewer adverse reactions, high total effective rate and low recurrence rate, which is worthy of clinical popularization. Related Articles | Metrics

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Analysis of the correlation between the level blood lactate and procalcitonin and prognosis in children with sepsis HUANG Xueping 2016, 8 (6):  631-635.  doi: 10.3969/j.issn.1674-3865.2016.06.027 Abstract ( 424 )   PDF (439KB) ( 136 )   Save Objective:To investigate the relationship between the levels of blood lactate and procalcitonin and the prognosis of sepsis in children in order to reduce the mortality of sepsis. Methods:From March 2013 to February 2016, 53 patients with sepsis were admitted to Pediatric Department of Laibin People 's Hospital. According to the prognosis, the patients were divided into survival group(38 cases) and death group(15 cases). The levels of blood lactate and procalcitonin were compared between the two groups. According to the blood lactate level, the 53 cases of sepsis were divided into 3 groups, 27 cases(<2.0 mmol/L) in low lactic acid group(A), 17 cases in the medium lactic acid group(2.0~3.9 mmol/L)(B) and 9 cases in the high lactic acid group(≥4.0 mmol/L)(C). The survival and death rate of the three groups(0.05~2.0 μg/L) were compared. According to the level of procalcitonin, these patients were divided into 4 groups:5 cases(<0.05 μg/L) in normal group(D),15 cases(0.05~2.0 μg/L) in slight increase group(E),8 cases(2.1~10 μg/L) in moderate increase group(F) and 15 cases(>10 μg/L) in significant increase group(G).The survival rate and mortality of the four groups were compared. The ROC curves in predicting death were compared(P<0.01). Results:The levels of blood lactate and procalcitonin in the survival group were significantly lower than those in the death group(P<0.05). When the lactate level was moderately increased,the mortality increased significantly, similar to the survival rate, and there was no statistal difference(P>0.05).When the level of procalcitonin increased to a moderate or significant level, the mortality increased significantly, and the survival rate was significantly higher than that of the survival rate(P<0.05), the difference being statistically significant(P<0.05). The prediction of sepsis mortality was more accurate when blood lactate levels were ≥2.0 mmol/L(especially≥4.0 mmol/L) and procalcitonin>2.0 μg/L(especially>10 μg/L). Conclusion：The levels of blood lactate and procalcitonin are closely related to the prognosis of sepsis, and the combined detection of serum lactic acid and procalcitonin may be more helpful to evaluate the situation and prognosis of sepsis. Related Articles | Metrics

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High quality nursing based on ADL rating scale in the rehabilitation of children with cerebral palsy WANG Qian 2016, 8 (6):  635-637.  doi: 10.3969/j.issn.1674-3865.2016.06.028 Abstract ( 318 )   PDF (341KB) ( 146 )   Save Objective:To explore the effect of comprehensive rehabilitation nursing mode on improving the ability of daily life of children with cerebral palsy. Methods:From October 2015 to February 2016,101 children with cerebral palsy in the rehabilitation ward of Children's Hospital of Shenyang were studied. The ADL scale was used to evaluate the children's life ability and the implementation of comprehensive rehabilitation treatment, including exercise therapy, occupational therapy, language treatment, traditional Chinese medicine treatment, physical therapy and other comprehensive rehabilitation Methods for nursing. The children were assessed after three days of hospital admission and before discharge, including the rehabilitation of children's self-care ability, action and cognitive communication were evaluated. Results:Before discharge, action score was 57.3±12.1,and ADL score was 59.4±10.3, significantly higher than that on admission, 45.7±10.2 and 47.7±10.1,there being statistically significant difference(P<0.05). Conclusion：The high quality nursing care based on ADL rating scale in the rehabilitation of children with cerebral palsy can effectively improve the self-care ability of children, which is of great significance in reducing the financial burden on families. Related Articles | Metrics

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Nursing intervention in children with lobar pneumonia GAO Xiaoling 2016, 8 (6):  638-640.  doi: 10.3969/j.issn.1674-3865.2016.06.029 Abstract ( 316 )   PDF (347KB) ( 218 )   Save Objective:To observe the effect of two different kinds of nursing intervention on the children with lobar pneumonia. Methods:Eighty cases of children with pneumonia, which were treated in the Fifth People's Hospital of Shenyang from January 2015 to January 2016, were randomly divided into two groups. Thirty-five cases of children with pneumonia in the experiment group received additional nursing intervention, including aerosol inhalation, postural drainage and chest physical therapy on the basis of routine drug treatment, while 45 cases in the control group only received the routine drug treatment. Compare the time that clinical symptoms disappeared, such as fever, asthma, cough and crackles. Nursing effect of two groups were compared. Results:Total effective rate of  nursing in experiment group was 94.3%(33/35),which was higher than that of control group(73.3%, 33/45)（P<0.05）. There were significant differences between the two groups on the disappearance time of crackles and asthma（P<0.05）, but there were no significant differences between the two groups on that of fever and cough（P＞0.05）. Conclusion：Appropriate nursing intervention is beneficial to the rehabilitation of the children with pneumonia. Related Articles | Metrics

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Application of psychological nursing in outpatient department of pediatrics LI Jibing, QIU Jing 2016, 8 (6):  640-642.  doi: 10.3969/j.issn.1674-3865.2016.06.030 Abstract ( 321 )   PDF (380KB) ( 102 )   Save Objective:To analyze the value of psychological nursing in outpatient department of pediatrics. Methods:From October 2014 to February 2016, 252 children and their parents were selected as the research object from Shenhe Maternal and Child Health Clinics. They were randomly divided into observation group and control group, 126 cases in each group. The control group received conventional nursing and outpatient treatment; the observation group was given psychological nursing based on the treatment for control group. The compliance of children and parents' satisfaction were compared between two groups. Results:In observation group, the compliance of children and parents' satisfaction were significantly better than the control group, there being statistical significance(P<0.05). Conclusion：The psychological nursing can improve the compliance of children and parents' satisfaction, and it is worthy of popularization in pediatric clinics. Related Articles | Metrics

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Analysis of serum 25 hydroxy vitamin D level of children with cerebral palsy LIAO Xin，QI Tengche，WEN Jiangge，LI Na，QI Yao 2016, 8 (6):  643-646.  doi: 10.3969/j.issn.1674-3865.2016.06.031 Abstract ( 388 )   PDF (425KB) ( 72 )   Save Objective:To analyze vitamin D(Vit D) level of children with cerebral palsy in Shenyang. Methods:From April 2015 to June 2015,113 children with cerebral palsy hospitalized in the Rehabilitation Department of Shenyang Children's Hospital aged 1~12 were selected as the observation group,150 confirmed by healthy children roution physical examination aged 1~12 were selected as the control group. High performance liquid chromatography was used to detect the level of serum Vit D, and 25(OH)D levels were compared between the two groups. Results:The average level of 25(OH)D (20.7±6.0 μg/L) of observation group was lower than that of the control group（25.3±7.5 μg/L），the difference being significant(P<0.01）. The level of 25(OH)D of observation group was lower than that of control group among all the age groups（P<0.05）. The incidence of 25(OH)D insufficiency and 25(OH)D deficiency in 1~3 age group and >3~6 age group of observation group was higher than that in control group, and the difference was significant（P<0.05）;there was no significant difference on the incidence of 25(OH)D insufficiency and 25(OH)D deficiency in >6~12 age group（P＞0.05）. Conclusion：The serum level of 25(OH)D in children with cerebral palsy is significantly lower than that in healthy children. In order to get better rehabilitation effect, in addition to routine rehabilitation training for children with cerebral palsy, we should also pay attention to the level of 25(OH)D. Related Articles | Metrics

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Distribution of allergens in children with allergic diseases in Liaoyang area LI Tingting 2016, 8 (6):  646-648.  doi: 10.3969/j.issn.1674-3865.2016.06.032 Abstract ( 329 )   PDF (328KB) ( 103 )   Save Objective:Through detecting and analyzing the serum allergen in children with allergic diseases and suspected allergic diseases in Liaoyang area, to provide evidence for the prevention and treatment of allergic diseases. Methods:A total of 2 641 children with allergic diseases and suspected allergic diseases were screened by western blotting, and clinical data were analysed retrospectively. Results:Totally 737(28.19%) out of 2 641 children were with positive allergens, 1 717 cases were 0-3-year old, and 394(22.95%) of them were positive for allergen screening; in 897 cases of 3-14-year old children， 343 cases(38.24%) were positive for allergen screening. Inhalant allergens were as follows(from high to low): house dust mites, mixed mold, dog hair dander, cat hair dander, house dust, mixed grass pollen(Artemisia/short ragweed/Humulus/amaranth), mixed tree pollen(cypress/elm/willow/birch/maple/walnut/sycamore/poplar)，and cockroaches； food allergens were as follows(from high to low): milk, eggs, crab, cashew nuts/peanuts/soy, shellfish/fish, shrimp, beef/lamb, mango/apple/cherry/peach;0-3-year old children were commonly allergic to milk, eggs and other food allergens , and 3-14-year old children were commonly allergic to house dust mites, mold and other mixed inhalant allergens. Conclusion：Milk, eggs and other food allergens are major allergens of allergic diseases in 0-3-year old children, with the age growing, food allergens gradually decreased, while house dust mites, mixed mold and other inhaled allergens become the main allergen. Related Articles | Metrics